Effect of hypercapnia and other disturbances in the acid-base-balance on panic disorder.

J Zandbergen, H Pols, C De Loof, H Lousberg, E Griez
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Abstract

Naturally occurring panic attacks and various interventions which trigger anxiety in panic patients are accompanied by disturbances in the acid-base balance. Carbon dioxide appears to play an important role in many experimental panic provoking conditions. The influence of respiratory and metabolic pH disturbances on cerebral physiology is discussed and speculations are made about the possible mechanisms underlying CO2-induced anxiety in panic disorder.

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高碳酸血症及其他酸碱平衡紊乱对惊恐障碍的影响。
自然发生的惊恐发作和引起惊恐患者焦虑的各种干预措施都伴随着酸碱平衡的紊乱。二氧化碳似乎在许多引起恐慌的实验条件下起着重要作用。讨论了呼吸和代谢pH紊乱对大脑生理的影响,并推测了二氧化碳引起恐慌症焦虑的可能机制。
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