The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China.

IF 1.5 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-01-24 DOI:10.1080/10641963.2024.2303999
Yue Yuan, Jing Shi, Wei Sun, Xiangqing Kong
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Abstract

Background: The atherogenic index of plasma (AIP) is a novel metabolic biomarker of atherosclerosis. Nevertheless, the association between the AIP and new-onset hypertension has not been elucidated in the Chinese population.

Methods: Prospective data were obtained from 3150 participants aged ≥ 18 years in the China Health and Nutrition Survey from 2009 to 2015. The AIP is a logarithmically transformed ratio of triglycerides to high-density lipoprotein cholesterol in molar concentration. Cox regression analysis was used to determine the association of AIP index with new-onset hypertension.

Results: After the six-year follow-up, 1054 (33.4%) participants developed new-onset hypertension. The participants were divided into AIP quartile groups (Q1-Q4). Compared with those in Q1, subjects in Q3-4 had nearly 1.35 times the risk of new-onset hypertension after full adjustment [Q3: hazard ratio (HR): 1.35, 95% confidence interval (CI): 1.13-1.62; Q4: HR: 1.35, 95% CI: 1.13-1.64]. The risks of new-onset hypertension were nearly 1.30 times higher in subjects in Q2-4 than in subjects in Q1 (p < .01) after the full adjustment when we excluded subjects with diabetes and/or chronic kidney diseases. There was a significant difference [HR (CI): 1.27 (1.04-1.54) vs. 0.90 (0.69-1.18)] when subjects were divided into two groups according to body mass index (BMI) level (<24 vs. ≥24 kg/m2).

Conclusions: The present study suggested that individuals with a higher AIP index are associated with new-onset hypertension, independent of kidney function and glucose levels. The association was stronger in subjects with normal BMI, which may provide early screening of metabolomics in hypertension prevention.

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血浆致动脉粥样硬化指数与新发高血压风险之间的正相关关系:一项在中国进行的全国性队列研究。
背景:血浆致动脉粥样硬化指数(AIP血浆致动脉粥样硬化指数(AIP)是动脉粥样硬化的一种新型代谢生物标志物。然而,在中国人群中,血浆致动脉粥样硬化指数与新发高血压之间的关系尚未得到阐明:方法:我们从 2009 年至 2015 年中国健康与营养调查的 3150 名年龄≥ 18 岁的参与者中获得了前瞻性数据。AIP是甘油三酯与高密度脂蛋白胆固醇摩尔浓度的对数转换比值。Cox回归分析用于确定AIP指数与新发高血压的关系:随访六年后,1054 人(33.4%)罹患新发高血压。参与者被分为AIP四分位组(Q1-Q4)。经全面调整后,与 Q1 组相比,Q3-4 组的受试者新发高血压的风险几乎是 Q1 组的 1.35 倍[Q3:危险比(HR):1.35,95% 置信区间(CI):1.13-1.62;Q4:HR:1.35,95% 置信区间(CI):1.13-1.64]。第二至第四季度受试者新发高血压的风险是第一季度受试者的近 1.30 倍(P 2):本研究表明,与肾功能和血糖水平无关,AIP 指数越高的人与新发高血压越相关。在体重指数正常的受试者中,这种关联性更强,这可能为代谢组学在高血压预防中提供早期筛查。
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来源期刊
CiteScore
3.90
自引率
0.80%
发文量
66
审稿时长
6-12 weeks
期刊介绍: Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.
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