Glycolytic dysregulation in Alzheimer's disease: unveiling new avenues for understanding pathogenesis and improving therapy.

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI:10.4103/NRR.NRR-D-24-00190
You Wu, Lijie Yang, Wanrong Jiang, Xinyuan Zhang, Zhaohui Yao
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Abstract

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative treatments. The current therapeutic strategies, primarily based on cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists, offer limited symptomatic relief without halting disease progression, highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's disease. Recent studies have provided insights into the critical role of glycolysis, a fundamental energy metabolism pathway in the brain, in the pathogenesis of Alzheimer's disease. Alterations in glycolytic processes within neurons and glial cells, including microglia, astrocytes, and oligodendrocytes, have been identified as significant contributors to the pathological landscape of Alzheimer's disease. Glycolytic changes impact neuronal health and function, thus offering promising targets for therapeutic intervention. The purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and progression. Comprehensive focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments, emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

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阿尔茨海默病的糖酵解失调:揭示了解发病机制和改善治疗的新途径。
阿尔茨海默病对全球健康构成了重大挑战,因为患者的认知能力会逐渐下降,而且缺乏治疗方法。目前的治疗策略主要基于胆碱酯酶抑制剂和 N-甲基-D-天冬氨酸受体拮抗剂,这些药物只能有限地缓解症状,却不能阻止疾病的发展,因此迫切需要新的研究方向来解决阿尔茨海默病的关键机制问题。最近的研究揭示了糖酵解这一大脑基本能量代谢途径在阿尔茨海默病发病机制中的关键作用。神经元和神经胶质细胞(包括小胶质细胞、星形胶质细胞和少突胶质细胞)内糖酵解过程的改变已被确定为阿尔茨海默病病理特征的重要因素。糖酵解变化影响神经元的健康和功能,从而为治疗干预提供了有希望的靶点。本综述旨在整合当前与阿尔茨海默病相关的糖酵解改变方面的知识,并探讨这些异常导致疾病发生和发展的机制。全面关注糖酵解功能障碍影响阿尔茨海默病病理学的途径,将有助于深入了解潜在的治疗靶点和策略,为开创性的治疗方法铺平道路。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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