MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder.

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-07-01 Epub Date: 2024-07-29 DOI:10.4103/NRR.NRR-D-24-00354
Bridget Martinez, Philip V Peplow
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Abstract

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life events. Currently, there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress disorder. In addition, the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate treatment. Evidence suggests that this condition is a multisystem disorder that affects many biological systems, raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress disorder. We performed a PubMed search for microRNAs (miRNAs) in post-traumatic stress disorder (PTSD) that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December 2023. These included four studies with whole blood, seven with peripheral blood mononuclear cells, four with plasma extracellular vesicles/exosomes, and one with serum exosomes. One of these studies had also used whole plasma. Two studies were excluded as they did not involve microRNA biomarkers. Most of the studies had collected samples from adult male Veterans who had returned from deployment and been exposed to combat, and only two were from recently traumatized adult subjects. In measuring miRNA expression levels, many of the studies had used microarray miRNA analysis, miRNA Seq analysis, or NanoString panels. Only six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to controls. The miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood; miR-193a-5p, -7113-5p, -125a, -181c, and -671-5p in peripheral blood mononuclear cells; miR-10b-5p, -203a-3p, -4488, -502-3p, -874-3p, -5100, and -7641 in plasma extracellular vesicles/exosomes; and miR-18a-3p and -7-1-5p in blood plasma. Several important limitations identified in the studies need to be taken into account in future studies. Further studies are warranted with war veterans and recently traumatized children, adolescents, and adults having PTSD and use of animal models subjected to various stressors and the effects of suppressing or overexpressing specific microRNAs.

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作为诊断创伤后应激障碍潜在生物标志物的微RNA。
创伤后应激障碍是一种因遭受严重创伤而导致的精神障碍。目前,还没有有效的生物标志物或实验室检测方法可以区分创伤幸存者是否患有创伤后应激障碍。此外,创伤后应激障碍临床表现的异质性以及与其他疾病症状的重叠会导致误诊和治疗不当。有证据表明,创伤后应激障碍是一种多系统疾病,会影响许多生物系统,因此外周疾病标志物有可能被用来诊断创伤后应激障碍。我们在 PubMed 上搜索了创伤后应激障碍(PTSD)中可作为诊断生物标志物的 microRNAs (miRNAs),并找到了 18 篇原创研究文章,这些文章是针对人类患者进行的研究,发表于 2012 年 1 月至 2023 年 12 月。其中四项研究使用了全血,七项使用了外周血单核细胞,四项使用了血浆细胞外囊泡/外泌体,一项使用了血清外泌体。其中一项研究还使用了全血浆。有两项研究因未涉及 microRNA 生物标记物而被排除在外。大多数研究收集的样本都来自于从战场上退役回来的成年男性退伍军人,只有两项研究的样本来自于最近受到创伤的成年受试者。在测量 miRNA 表达水平时,许多研究使用了微阵列 miRNA 分析、miRNA Seq 分析或 NanoString 面板。只有六项研究使用了实时聚合酶链反应测定法来确定/验证创伤后应激障碍受试者与对照组相比的 miRNA 表达情况。在这些研究中发现/验证的 miRNA 可被视为创伤后应激障碍的潜在候选生物标志物,包括全血中的 miR-3130-5p;外周血单核细胞中的 miR-193a-5p、-7113-5p、-125a、-181c、-671-5p;血浆细胞外囊泡/外泌体中的 miR-10b-5p、-203a-3p、-4488、-502-3p、-874-3p、-5100、-7641;以及血浆中的 miR-18a-3p、-7-1-5p。研究中发现的一些重要局限性需要在今后的研究中加以考虑。有必要对退伍军人和最近遭受创伤的儿童、青少年和患有创伤后应激障碍的成人进行进一步研究,并使用遭受各种压力的动物模型,研究抑制或过量表达特定 microRNA 的影响。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
期刊最新文献
Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice. Glycolytic dysregulation in Alzheimer's disease: unveiling new avenues for understanding pathogenesis and improving therapy. Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery. C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury. Decoding molecular mechanisms: brain aging and Alzheimer's disease.
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