Obesity is associated with incident chronic kidney disease in individuals with normal renal function.

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL Korean Journal of Internal Medicine Pub Date : 2024-09-01 Epub Date: 2024-08-13 DOI:10.3904/kjim.2023.491
Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae
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Abstract

Background/aims: Obesity has known to be a modifiable risk factor associated with worse outcomes in chronic kidney disease (CKD), but few studies have examined the impact of obesity on CKD incidence in the general population. The purpose of this study was to investigate the role of body mass index (BMI) and waist-to-hip ratio (WHR) as predictors of incident CKD and to evaluate the impact of weight reduction on CKD prevention.

Methods: A total of 2,711 participants from a community-based cohort with normal renal function were prospectively analyzed. Among participants with obesity, we analyzed the change in WHR to evaluate the association of obesity reduction with CKD development.

Results: During a mean follow-up of 11.03 ± 4.22 years, incident CKD occurred in 190 (7.0%) participants. In the fully adjusted multivariable Cox proportional hazard models, the risk of incident CKD increased with higher BMI (hazard ratio, 1.06; 95% confidence interval, 1.00-1.11; p = 0.033) and higher WHR (hazard ratio, 1.33; 95% confidence interval, 1.07-1.66; p = 0.009). In the Kaplan-Meier analysis, cumulative adverse renal events were significantly more common in the maintained obesity group than in the reduced obesity group (p = 0.001).

Conclusion: Both higher BMI and WHR were associated with development of CKD, but the magnitude of the effect of WHR was higher than that of BMI. Moreover, reducing obesity would be beneficial for renal prognosis.

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对于肾功能正常的人来说,肥胖与慢性肾病的发生有关。
背景/目的:众所周知,肥胖是与慢性肾脏病(CKD)不良预后相关的一个可改变的风险因素,但很少有研究探讨肥胖对普通人群中 CKD 发病率的影响。本研究旨在调查体重指数(BMI)和腰臀比(WHR)作为慢性肾脏病发病率预测因素的作用,并评估减轻体重对预防慢性肾脏病的影响:我们对社区队列中肾功能正常的 2711 名参与者进行了前瞻性分析。在肥胖的参与者中,我们分析了WHR的变化,以评估减少肥胖与CKD发展的关系:结果:在平均 11.03 ± 4.22 年的随访期间,有 190 人(7.0%)发生了慢性肾功能衰竭。在完全调整的多变量 Cox 比例危险模型中,发生 CKD 的风险随着体重指数(BMI)的升高(危险比为 1.06;95% 置信区间为 1.00-1.11;p = 0.033)和 WHR 的升高(危险比为 1.33;95% 置信区间为 1.07-1.66;p = 0.009)而升高。在卡普兰-梅耶分析中,持续肥胖组的累积肾脏不良事件发生率明显高于减少肥胖组(p = 0.001):结论:较高的体重指数和 WHR 都与慢性肾脏病的发生有关,但 WHR 的影响程度高于体重指数。此外,减少肥胖将有利于肾脏预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Korean Journal of Internal Medicine
Korean Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
5.10
自引率
4.20%
发文量
129
审稿时长
20 weeks
期刊介绍: The Korean Journal of Internal Medicine is an international medical journal published in English by the Korean Association of Internal Medicine. The Journal publishes peer-reviewed original articles, reviews, and editorials on all aspects of medicine, including clinical investigations and basic research. Both human and experimental animal studies are welcome, as are new findings on the epidemiology, pathogenesis, diagnosis, and treatment of diseases. Case reports will be published only in exceptional circumstances, when they illustrate a rare occurrence of clinical importance. Letters to the editor are encouraged for specific comments on published articles and general viewpoints.
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