Analysis of the current status and associated risk factors of cognitive function in Tibetan hypertensive patients at various altitudes.

IF 1.5 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE Clinical and Experimental Hypertension Pub Date : 2024-12-31 Epub Date: 2024-08-27 DOI:10.1080/10641963.2024.2393331
Long Yin, Xiaoming Zhang, Huijuan Zhang, Ruizhen Li, Jing Zeng, Kaixuan Dong, Yi Wang, Xinghui Li
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Abstract

Objective: This study aims to explore the current cognitive status and identify risk factors associated with cognitive function in Tibetan hypertensive patients living at various altitudes.

Methods: The Simple Mental Status Scale (MMSE) was used to evaluate the cognitive function of 611 Tibetan hypertensive patients at various altitudes in Gannan Tibetan Autonomous Prefecture. Afterward, we conducted an analysis to identify the factors influencing their cognitive function.

Results: The study found that the prevalence of cognitive dysfunction was 22.3%, with a higher incidence at high altitude (group D 29.0%) compared to low altitude (group A 16.0%). The study conducted a binary logistic regression analysis to identify the risk factors for cognitive dysfunction. The analysis revealed that altitude, age, body mass index, marital status, education, income level, and blood pressure control level were all significant risk factors. After controlling for age, body mass index, marital status, educational level, income level, and blood pressure control level, the risk of developing cognitive dysfunction was 2.773 times higher (p < .05) for individuals in group C at high altitude and 2.381 times higher (p < .05) for individuals in group D at high altitude compared to those in group A at low altitude.

Conclusions: Altitude plays a role in the development of cognitive dysfunction in hypertensive patients. Tibetan hypertensive patients living at high altitudes may be at a higher risk of cognitive dysfunction compared to those living at lower altitudes. Therefore, interventions should be targeted to prevent or mitigate potential cognitive impairment.

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不同海拔地区藏族高血压患者认知功能现状及相关风险因素分析。
研究目的本研究旨在探讨生活在不同海拔地区的藏族高血压患者的认知功能现状,并确定与认知功能相关的风险因素:方法:采用简易精神状态量表(MMSE)对甘南藏族自治州不同海拔地区的 611 名藏族高血压患者的认知功能进行评估。随后,我们对影响认知功能的因素进行了分析:研究发现,认知功能障碍的发生率为 22.3%,与低海拔地区(A 组 16.0%)相比,高海拔地区(D 组 29.0%)的发生率更高。研究进行了二元逻辑回归分析,以确定认知功能障碍的风险因素。分析结果显示,海拔高度、年龄、体重指数、婚姻状况、教育程度、收入水平和血压控制水平都是重要的风险因素。在控制了年龄、体重指数、婚姻状况、受教育程度、收入水平和血压控制水平后,认知功能障碍的发病风险是正常人的 2.773 倍(p p 结论):海拔高度对高血压患者认知功能障碍的发生有一定影响。与生活在低海拔地区的藏族高血压患者相比,生活在高海拔地区的藏族高血压患者发生认知功能障碍的风险可能更高。因此,应采取有针对性的干预措施,预防或减轻潜在的认知功能障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.90
自引率
0.80%
发文量
66
审稿时长
6-12 weeks
期刊介绍: Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.
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