Selective mineralization at hydrogel interface induced by fusion between peptide hydrogels†

IF 3.2 3区 工程技术 Q2 CHEMISTRY, PHYSICAL Molecular Systems Design & Engineering Pub Date : 2024-09-03 DOI:10.1039/D4ME00112E
Yongbaek Kim, Hiroto Isobe, Keishi Nishio and Kazuki Murai
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Abstract

Biomineralization has garnered attention not only for its fundamental role in understanding the mechanisms of biomineral formation but also as a method for fabricating next-generation functional materials. In this study, we investigated the nucleation, crystal growth, and particle growth processes of calcium phosphates (CaPs) formed using selective mineralization at the hydrogel interface induced by the fusion of peptide hydrogels. After 1 day of mineralization, band-like white precipitates were observed at the fusion interface of the hydrogels. Notably, the nucleation and crystal growth of the mineralized CaP exhibited different behaviors owing to the differences in the properties of the reaction interface for mineralization. The selective nucleation and crystal growth of the CaPs at the hydrogel interface were attributed to (1) the local concentration of mineral sources near the peptide network, driven by electrostatic interactions between the polar functional groups and mineral source ions, and (2) selective crystal growth of the CaPs induced by the nanostructure of the surface functional groups.

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多肽水凝胶之间的融合诱导水凝胶界面的选择性矿化
生物矿化不仅在理解生物矿物形成机制方面发挥着基础性作用,而且还是制造下一代功能材料的一种方法,因而备受关注。在本研究中,我们研究了多肽水凝胶融合诱导的水凝胶界面选择性矿化形成的磷酸钙(CaPs)的成核、晶体生长和颗粒生长过程。矿化一天后,在水凝胶的融合界面上观察到了带状白色沉淀。值得注意的是,由于矿化反应界面的性质不同,矿化 CaP 的成核和晶体生长表现出不同的行为。水凝胶界面上 CaPs 的选择性成核和晶体生长归因于:(1) 极性官能团和矿物源离子之间的静电作用驱动了肽网络附近矿物源的局部富集;(2) 表面官能团的纳米结构诱导了 CaPs 的选择性晶体生长。
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来源期刊
Molecular Systems Design & Engineering
Molecular Systems Design & Engineering Engineering-Biomedical Engineering
CiteScore
6.40
自引率
2.80%
发文量
144
期刊介绍: Molecular Systems Design & Engineering provides a hub for cutting-edge research into how understanding of molecular properties, behaviour and interactions can be used to design and assemble better materials, systems, and processes to achieve specific functions. These may have applications of technological significance and help address global challenges.
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Back cover Back cover Dual responsive fluorescence switching of organohydrogel towards base/acid† Back cover Graph-based networks for accurate prediction of ground and excited state molecular properties from minimal features†
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