FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival.

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-07-01 Epub Date: 2024-04-03 DOI:10.4103/NRR.NRR-D-22-00867
Yuhui Kou, Zongxue Jin, Yusong Yuan, Bo Ma, Wenyong Xie, Na Han
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Abstract

JOURNAL/nrgr/04.03/01300535-202507000-00031/figure1/v/2024-09-09T124005Z/r/image-tiff FK506 (Tacrolimus) is a systemic immunosuppressant approved by the U.S. Food and Drug Administration. FK506 has been shown to promote peripheral nerve regeneration, however, its precise mechanism of action and its pathways remain unclear. In this study, we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve, increased the numbers of motor and sensory neurons, reduced inflammatory responses, markedly improved the conduction function of the injured nerve, and promoted motor function recovery. These findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

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FK506 通过抑制神经炎症反应和促进神经元存活,有助于外周神经再生。
JOURNAL/nrgr/04.03/01300535-202507000-00031/figure1/v/2024-09-09T124005Z/r/image-tiff FK506(他克莫司)是美国食品和药物管理局批准的一种全身性免疫抑制剂。已有研究表明 FK506 能促进周围神经再生,但其确切的作用机制和途径仍不清楚。在这项研究中,我们建立了大鼠坐骨神经损伤模型,发现 FK506 能改善损伤坐骨神经的形态,增加运动和感觉神经元的数量,减少炎症反应,明显改善损伤神经的传导功能,促进运动功能的恢复。这些研究结果表明,FK506 可降低神经元损伤后的炎症强度,增加存活神经元的数量,从而促进周围神经结构的恢复和功能再生。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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