Interconnections between diabetic corneal neuropathy and diabetic retinopathy: diagnostic and therapeutic implications.

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-09-20 DOI:10.4103/NRR.NRR-D-24-00509
Mingyi Yu, Faith Teo En Ning, Chang Liu, Yu-Chi Liu
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Abstract

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes mellitus. Diabetic corneal neuropathy refers to the progressive damage of corneal nerves. Diabetic retinopathy has traditionally been considered as damage to the retinal microvasculature. However, growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit, which includes both the retinal vascular structures and neural tissues. Diabetic retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular screening. However, diabetic corneal neuropathy is commonly overlooked and underdiagnosed, leading to severe ocular surface impairment. Several studies have found that these two conditions tend to occur together, and they share similarities in their pathogenesis pathways, being triggered by a status of chronic hyperglycemia. This review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy, whether diabetic corneal neuropathy precedes diabetic retinopathy, as well as the relation between the stage of diabetic retinopathy and the severity of corneal neuropathy. We also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

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糖尿病角膜神经病变与糖尿病视网膜病变之间的相互联系:诊断和治疗意义。
糖尿病角膜神经病变和糖尿病视网膜病变是糖尿病引起的眼部并发症。糖尿病角膜神经病变是指角膜神经逐渐受损。糖尿病视网膜病变传统上被认为是视网膜微血管的损伤。然而,越来越多的证据表明,糖尿病视网膜病变是一种复杂的神经血管疾病,是由神经血管单元(包括视网膜血管结构和神经组织)功能障碍引起的。糖尿病视网膜病变是导致失明的主要原因之一,经常作为糖尿病眼底筛查的一部分进行筛查。然而,糖尿病角膜神经病变通常被忽视和诊断不足,导致严重的眼表损害。多项研究发现,这两种病症往往同时发生,它们的发病机制相似,都是由慢性高血糖状态引发的。本综述旨在讨论糖尿病角膜神经病变与糖尿病视网膜病变之间的相互联系,糖尿病角膜神经病变是否先于糖尿病视网膜病变,以及糖尿病视网膜病变的阶段与角膜神经病变严重程度之间的关系。我们还致力于探索糖尿病眼角膜筛查的相关性,以及利用角膜神经测量来监测糖尿病视网膜病变进展的可能性。
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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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