Comment on "Extracellular Vesicles Slow Down Aβ(1-42) Aggregation by Interfering with the Amyloid Fibril Elongation Step".

IF 4.1 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY ACS Chemical Neuroscience Pub Date : 2024-11-06 Epub Date: 2024-10-09 DOI:10.1021/acschemneuro.4c00601
Mohsin Shafiq, Andreu Matamoros-Angles, Sussane Caroline Meister, Markus Glatzel
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引用次数: 0

Abstract

Halipi et al. explored the impact of extracellular vesicles (EVs) on amyloid-β (Aβ) aggregation. They concluded that EVs reduce Aβ aggregation, as seen by shorter and thicker fibrils. While we agree with the complex role of EVs in Alzheimer's disease, we are sceptical of the claim that EVs slow down Aβ aggregation, noting missing key references. Previous literature rather suggests that EVs (derived from neuronal cell lines) accelerate the process of Aβ fibrillation and plaque formation. Halipi et al.'s findings may be skewed due to the lack of essential neuronally expressed Aβ-binding partners, like the prion protein (PrPC) in their EV samples. The commentary, in the light of included original experiments and cited literature, suggests that membrane proteins like PrPC are crucial to fully understand the role of EVs in Aβ aggregation, and Halipi et al.'s conclusions should be reexamined in light of these factors.

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关于 "细胞外小泡通过干扰淀粉样蛋白纤维伸长步骤减缓 Aβ(1-42)聚集 "的评论
Halipi 等人探讨了细胞外囊泡 (EVs) 对淀粉样蛋白-β(Aβ)聚集的影响。他们的结论是,细胞外小泡可减少 Aβ 的聚集,表现为纤维更短更粗。虽然我们同意 EVs 在阿尔茨海默病中的复杂作用,但我们对 EVs 减缓 Aβ 聚集的说法持怀疑态度,并注意到缺少关键的参考文献。以前的文献反而表明,EVs(来自神经细胞系)加速了 Aβ 纤维化和斑块形成的过程。Halipi等人的研究结果可能存在偏差,因为他们的EV样本中缺乏神经元表达的重要Aβ结合伙伴,如朊病毒蛋白(PrPC)。根据包含的原始实验和引用的文献,该评论认为,像 PrPC 这样的膜蛋白对于充分理解 EV 在 Aβ 聚集中的作用至关重要,Halipi 等人的结论应根据这些因素重新审视。
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来源期刊
ACS Chemical Neuroscience
ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL
CiteScore
9.20
自引率
4.00%
发文量
323
审稿时长
1 months
期刊介绍: ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research
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