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Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na+ excretion and insulin resistance. 血小板反应蛋白2是一种新的原发性高血压生物标志物,与夜间Na+排泄和胰岛素抵抗有关。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2023-12-31 Epub Date: 2023-11-09 DOI: 10.1080/10641963.2023.2276029
Xiaoxin Zhou, Longlong Zhang, Xiaoqian Lin, Xi Chen, Hong Liu, Xiaoli Yuan, Qiuxia Zhao, Weiwei Wang, Xun Lei, Pedro A Jose, Chunyan Deng, Jian Yang

Background: Thrombospondins (TSPs) play important roles in several cardiovascular diseases. However, the association between circulating (plasma) thrombospondin 2 (TSP2) and essential hypertension remains unclear. The present study was aimed to investigate the association of circulating TSP2 with blood pressure and nocturnal urine Na+ excretion and evaluate the predictive value of circulating TSP2 in subjects with hypertension.

Methods and results: 603 newly diagnosed essential hypertensive subjects and 508 healthy subjects were preliminarily screened, 47 healthy subjects and 40 newly diagnosed essential hypertensive subjects without any chronic diseases were recruited. The results showed that the levels of circulating TSP2 were elevated in essential hypertensive subjects. The levels of TSP2 positively associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), and other clinical parameters, including homeostasis model assessment of insulin resistance (HOMA-IR), brachial-ankle pulse wave velocity, and serum triglycerides, but negatively associated with nocturnal urine Na+ concentration and excretion and high-density lipoprotein cholesterol. Results of multiple linear regressions showed that HOMA-IR and nocturnal Na+ excretion were independent factors related to circulating TSP2. Mantel-Haenszel chi-square test displayed linear relationships between TSP2 and SBP (χ2 = 35.737) and DBP (χ2 = 26.652). The area under receiver operating characteristic curve (AUROC) of hypertension prediction was 0.901.

Conclusion: Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of renal Na+ excretion, insulin resistance, and/or endothelial function.

背景:血小板反应蛋白(TSPs)在多种心血管疾病中发挥着重要作用。然而,循环(血浆)血小板反应蛋白2(TSP2)与原发性高血压之间的关系尚不清楚。本研究旨在探讨循环TSP2与血压和夜间尿Na+排泄的关系,并评估循环TSP2对高血压患者的预测价值。方法与结果:初筛603名新诊断原发性高血压患者和508名健康受试者,招募47名健康受检者和40名新诊断无任何慢性病的原发性血压受试者。结果显示,原发性高血压患者的循环TSP2水平升高。TSP2水平与收缩压(SBP)、舒张压(DBP)和其他临床参数呈正相关,包括胰岛素抵抗稳态模型评估(HOMA-IR)、臂踝脉搏波速度和血清甘油三酯,但与夜间尿Na+浓度和排泄以及高密度脂蛋白胆固醇负相关。多元线性回归结果表明,HOMA-IR和夜间Na+排泄是与循环TSP2相关的独立因素。Mantel-Haenszel卡方检验显示TSP2与SBP呈线性关系(χ = 35.737)和DBP(χ = 高血压预测的受试者工作特征曲线下面积(AUROC)为0.901。结论:我们的研究首次表明,TSP2的循环水平可能是原发性高血压的一个新的潜在生物标志物。TSP2和血压之间的关联可能至少部分与肾Na+排泄、胰岛素抵抗和/或内皮功能的调节有关。
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引用次数: 0
Diagnostic signature and immune characteristic of aging-related genes from placentas in Preeclampsia. 子痫前期胎盘中衰老相关基因的诊断特征和免疫特征。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-11 DOI: 10.1080/10641963.2022.2130930
Xiufang Wang, Andong He, Ka Cheuk Yip, Xiaoting Liu, Ruiman Li

Introduction: Preeclampsia (PE) is a serious pregnancy syndrome. Advanced maternal age (≥ 35 years old) is one of the major risk factors of PE and placental aging is considered to be related to this disease. However, the mechanisms underlying these phenomena remain obscured.

Methods: Gene expression profiles of PE and non-PE placental samples were curated from the GSE75010 dataset. A diagnostic model was constructed and immune characteristics of PE subtypes were estimated.

Results: A total of 58 aging-related genes, which may be associated with PE, were identified. Among them, LEP and FLT1 may be key aging-related genes. Based on 5 top genes (PIK3CB, FLT1, LEP, PIK3R1, CSNK1E), a diagnostic nomogram for PE was built (AUC = 0.872 in the GSE75010 dataset). Three molecular subtypes were clustered, which had different immune and angiogenesis characteristics.

Conclusion: The present study suggests the potential implications of aging-related genes in diagnosing PE. Diverse immune characteristics may be involved in the placental aging of PE.

导言子痫前期(PE)是一种严重的妊娠综合征。高龄产妇(≥ 35 岁)是子痫前期的主要风险因素之一,胎盘老化也被认为与子痫前期有关。然而,这些现象背后的机制仍不清楚:方法:从 GSE75010 数据集中收集 PE 和非 PE 胎盘样本的基因表达谱。结果:共发现 58 个与衰老相关的基因:结果:共鉴定出 58 个可能与 PE 相关的衰老相关基因。结果:共发现 58 个可能与 PE 相关的衰老相关基因,其中 LEP 和 FLT1 可能是关键的衰老相关基因。基于 5 个顶级基因(PIK3CB、FLT1、LEP、PIK3R1、CSNK1E),建立了 PE 的诊断提名图(GSE75010 数据集中的 AUC = 0.872)。三个分子亚型被聚类,它们具有不同的免疫和血管生成特征:本研究提示了衰老相关基因在诊断 PE 中的潜在意义。结论:本研究提示了衰老相关基因在诊断 PE 中的潜在意义,不同的免疫特征可能参与了 PE 的胎盘衰老。
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引用次数: 0
Knowledge, attitude and preparedness of healthcare students toward basic life support at King Khalid University, Abha, Kingdom of Saudi Arabia. 沙特阿拉伯王国阿卜哈哈国王哈立德大学保健专业学生对基本生命支持的知识、态度和准备。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-08-03 DOI: 10.1080/10641963.2022.2103145
Sirajudeen Shaik Alavudeen, Viqar Basharat, Ahmed Khaled Bahamdan, Vigneshwaran Easwaran, Ghadah Khaled Bahamdan, Md Sayeed Akhtar, Sultan Alshahrani, Ali Alqahtani, Krishnaraju Venkatesan

Background: Worldwide, millions of people die of sudden cardiac arrest every year. A well-timed cardiopulmonary resuscitation (CPR) increases the possibility of survival by two- to fourfolds. This study aimed to assess the knowledge, attitude, and preparedness of health care students toward basic life support (BLS) at King Khalid University.

Methods: A cross-sectional study was conducted among the health care students of King Khalid University from August to October 2020. Data were collected using a pretested, semi-structured questionnaire and the data were analyzed using Statistical Package for the Social Sciences.

Resulrs: The total number of participants was 346. Overall, the participant's knowledge regarding the BLS was inadequate. Majority of the participants were not aware of the acronyms used in BLS. The level of education has a significant impact on the knowledge, whereas gender has no significant impact on the knowledge. The answers to the attitude and the preparedness items were also not satisfying. Lack of knowledge is one of the common reasons for not performing BLS. Periodical training program and refresher courses were the most recommended methods to increase the knowledge toward the BLS.

Conclusion: It is evident from the current study that there is a lack of knowledge and preparedness toward BLS among most health care students. It is recommended to incorporate more BLS training and refresher courses in the health care college curricula.

背景:全世界每年有数百万人死于心脏骤停。及时的心肺复苏术(CPR)可使患者存活的可能性提高两到四倍。本研究旨在评估哈立德国王大学医护专业学生对基本生命支持(BLS)的知识、态度和准备。方法:对2020年8月- 10月哈立德国王大学卫生系学生进行横断面研究。使用预测试的半结构化问卷收集数据,使用社会科学统计软件包对数据进行分析。结果:总人数346人。总体而言,参与者对劳工统计局的了解是不充分的。大多数参与者不知道劳工统计局中使用的缩写词。受教育程度对知识有显著影响,性别对知识无显著影响。态度和准备项目的回答也不令人满意。缺乏知识是不执行劳工统计局的常见原因之一。定期的培训计划和进修课程是最受推荐的增加劳工统计局知识的方法。结论:从目前的研究中可以明显看出,大多数卫生保健学生对劳工统计局缺乏了解和准备。建议在卫生保健学院的课程中加入更多的劳工统计局培训和进修课程。
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引用次数: 1
A retrospective cohort study on the effects of Down's screening markers and maternal characteristics on pregnancy outcomes in preeclampsia. 唐氏筛查标志物及母体特征对子痫前期妊娠结局影响的回顾性队列研究
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-07-05 DOI: 10.1080/10641963.2022.2096055
Bin Wu, Wenwen Ning, Yijie Chen, Caihe Wen, Huimin Zhang, Yiming Chen

Background: To investigate the effects of down's screening markers and maternal characteristics on preeclampsia (PE) pregnancy outcome during early and middle pregnancy.

Methods: A retrospective study of a cohort of 246 PE and 18,709 No-PE pregnant women who participated in Down's screening during early and middle pregnancy was performed. Clinical data of pregnancy-related were collected. Multivariate binary logistic regression was used to analyze the adjusted odds ratio (aOR) and 95% confidence interval (CI) of Down's screening markers, maternal characteristics, pregnancy outcome, and other related variables, and to evaluate the influencing factors of each indicator on PE. P < .05 was considered to be statistically significant.

Results: Compared with the non-PE group, the concentration and median multiple (MoM) of pregnancy-associated plasma protein-A (PAPP-A) and free beta subunit of human chorionic gonadotropin (free β-hCG) in PE group were both lower (P < .001). Multivariate binary logistic regression analysis showed that low birth weight, hydronephrosis, premature delivery, fetal growth retardation, cesarean section, live birth, hyperlipemia, infection, decreased free β-hCG and first trimester maternal weight were risk factors for PE (aOR were: 7.552, 6.684, 4.154, 3.762, 3.612, 2.454, 1.757, 1.562, 1.270, and 1.077, respectively), while uterine scar, premature rupture of membranes and elevated PAPP-A were protective factors of PE (aOR were: 0.222, 0.328 and 0.612, respectively).

Conclusion: Decreased maternal serum PAPP-A level, increased free β-hCG, hyperlipemia, premature delivery, cesarean section, live birth, hydronephrosis, fetal growth retardation, low birth weight, and infection are risk factors for PE, while uterine scar and premature rupture of membrane are protective factors for PE.

背景:探讨唐氏筛查标志物及产妇特征对妊娠早期和中期子痫前期妊娠结局的影响。方法:回顾性研究246名PE孕妇和18709名妊娠早期和中期参加唐氏筛查的无PE孕妇。收集与妊娠相关的临床资料。采用多元二元logistic回归分析唐氏筛查标志物、母体特征、妊娠结局等相关变量的校正优势比(aOR)和95%置信区间(CI),评价各指标对PE的影响因素。结果:与未PE组比较,PE组妊娠相关血浆蛋白a (ppap -a)和人绒毛膜促性腺激素游离β亚基(游离β-hCG)的浓度和中位倍数(MoM)均较低(P)。产妇血清PAPP-A水平降低、游离β-hCG升高、高脂血症、早产、剖宫产、活产、肾积水、胎儿生长迟缓、低出生体重、感染是PE的危险因素,而子宫瘢痕、胎膜早破是PE的保护因素。
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引用次数: 0
Intermediate risk pulmonary embolism concomitant with or without lung cancer: a wide spectrum of features. 伴或不伴肺癌的中度危险肺栓塞:广泛的特征。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-06-29 DOI: 10.1080/10641963.2022.2093892
Yu-Jia Jin, Yi-Fan Jin, Xin-Yun Zhu, Bei-Lei Zhang, Cheng Chen

Objectives: We aimed to investigate the differences in clinical features between pulmonary embolism (PE) patients concomitant with lung cancer and without lung cancer (LC) and gain further understanding of the impact of lung cancer on pulmonary embolism.

Methods: This retrospective study sampled 114 patients diagnosed with pulmonary embolism from January 2017 to April 2021 in the First Affiliated Hospital of Soochow University. The patients were categorized into the LC group (n = 22) or non-LC group (n = 92). Myocardial injury, coagulation and blood cell parameters, along with imaging findings, were analyzed for the two groups. The primary outcome measure was the 90-day mortality.

Results: Of the 114 patients with pulmonary embolism in the present study, the 90 intermediate-risk patients were enrolled for further investigations. Compared to the non-LC group, patients in the LC group had milder myocardial injury, more severe coagulation function disorder, a higher incidence of central PE and a smaller change in diameter of the main pulmonary artery. We found that the occurrence of pericardial effusion created the risk of lung cancer in patients with pulmonary embolism, but there was no increase in the 90-day mortality for non-LC group versus LC group.

Conclusion: Intermediate risk PE patients concomitant with lung cancer seem to be more likely to present specific clinical features, accordingly, clinicians must pay great attention to PE patients concomitant with lung cancer and implement effective treatments to simultaneously manage the two conditions.

目的:探讨肺栓塞(PE)合并肺癌与非肺癌(LC)患者临床特征的差异,进一步了解肺癌对肺栓塞的影响。方法:回顾性研究选取2017年1月至2021年4月在苏州大学第一附属医院诊断为肺栓塞的114例患者。患者分为LC组(n = 22)和非LC组(n = 92)。分析两组患者心肌损伤、凝血、血细胞参数及影像学表现。主要结局指标为90天死亡率。结果:在本研究的114例肺栓塞患者中,90例中危患者被纳入进一步调查。与非LC组相比,LC组患者心肌损伤较轻,凝血功能障碍较重,中央PE发生率较高,肺动脉主干直径变化较小。我们发现,肺栓塞患者发生心包积液会增加肺癌的风险,但与LC组相比,非LC组的90天死亡率没有增加。结论:中危PE合并肺癌患者似乎更容易表现出特定的临床特征,因此,临床医生必须高度重视PE合并肺癌患者,并实施有效的治疗,同时控制这两种情况。
{"title":"Intermediate risk pulmonary embolism concomitant with or without lung cancer: a wide spectrum of features.","authors":"Yu-Jia Jin,&nbsp;Yi-Fan Jin,&nbsp;Xin-Yun Zhu,&nbsp;Bei-Lei Zhang,&nbsp;Cheng Chen","doi":"10.1080/10641963.2022.2093892","DOIUrl":"https://doi.org/10.1080/10641963.2022.2093892","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to investigate the differences in clinical features between pulmonary embolism (PE) patients concomitant with lung cancer and without lung cancer (LC) and gain further understanding of the impact of lung cancer on pulmonary embolism.</p><p><strong>Methods: </strong>This retrospective study sampled 114 patients diagnosed with pulmonary embolism from January 2017 to April 2021 in the First Affiliated Hospital of Soochow University. The patients were categorized into the LC group (n = 22) or non-LC group (n = 92). Myocardial injury, coagulation and blood cell parameters, along with imaging findings, were analyzed for the two groups. The primary outcome measure was the 90-day mortality.</p><p><strong>Results: </strong>Of the 114 patients with pulmonary embolism in the present study, the 90 intermediate-risk patients were enrolled for further investigations. Compared to the non-LC group, patients in the LC group had milder myocardial injury, more severe coagulation function disorder, a higher incidence of central PE and a smaller change in diameter of the main pulmonary artery. We found that the occurrence of pericardial effusion created the risk of lung cancer in patients with pulmonary embolism, but there was no increase in the 90-day mortality for non-LC group versus LC group.</p><p><strong>Conclusion: </strong>Intermediate risk PE patients concomitant with lung cancer seem to be more likely to present specific clinical features, accordingly, clinicians must pay great attention to PE patients concomitant with lung cancer and implement effective treatments to simultaneously manage the two conditions.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury. 右美托咪定减轻主动脉缺血再灌注损伤引起的肺细胞凋亡和炎症。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-07-05 DOI: 10.1080/10641963.2022.2093893
Dogus Hemsinli, Levent Tumkaya, Saban Ergene, S Ozan Karakisi, Tolga Mercantepe, Adnan Yilmaz

Objective: Despite significant improvements in interventional vascular aneurysm repair procedures and intensive care patient management, there has been no significant decrease in mortality due to ruptured abdominal aortic aneurysm. Oxidative stress is known to play a key role in secondary organ damage due to infrarenal aortic clamping. The aim of this study was to examine the potential protective effect of the alpha-2 adrenergic receptor agonist dexmedetomidine (DMT) on aortic occlusion-induced lung injury.

Methods: Thirty Sprague Dawley rats were allocated into control, ischemia-reperfusion (IR), and IR+DMT groups randomly. Vascular clamps were attached to the abdominal aorta in the IR and IR+DMT groups. Two-hour reperfusion was established 1 h after ischemia. The IR+DMT group received a single intraperitoneal 100 µg dose of DMT 30 min before infrarenal abdominal aortic clamping.

Results: IR due to aortic occlusion led to apoptosis, widespread inflammation, alveolar septal wall thickening due to bleeding and vascular congestion were observed in both types I and II pneumocytes. Malondialdehyde levels increased while glutathione decreased. However, DMT was found to lower apoptotic pneumocytes, alveolar-septal thickness, hemorrhage, vascular congestion, and malondialdehyde levels, while glutathione levels in lung tissue increased.

Conclusions: This study is the first to address the effects of DMT on the lung in a ruptured abdominal aortic aneurysm model. Our findings suggest that the alpha-2 adrenergic receptor agonist DMT reduces oxidative stress and apoptosis, thus protecting against aortic occlusion-induced pulmonary injury.

目的:尽管介入血管动脉瘤修复手术和重症监护患者管理有了显著改善,但腹主动脉瘤破裂的死亡率并没有显著下降。氧化应激在肾下主动脉夹持引起的继发性器官损伤中起关键作用。本研究的目的是研究α -2肾上腺素能受体激动剂右美托咪定(DMT)对主动脉闭塞性肺损伤的潜在保护作用。方法:将30只sd大鼠随机分为对照组、缺血再灌注组和缺血再灌注+DMT组。IR组和IR+DMT组在腹主动脉上附着血管夹。缺血后1小时建立2小时再灌注。IR+DMT组在腹主动脉夹持前30分钟单次腹腔注射100µg DMT。结果:I型和II型肺细胞均可观察到主动脉阻塞引起的IR导致细胞凋亡,广泛的炎症,肺泡间隔壁增厚导致出血和血管充血。丙二醛水平升高,而谷胱甘肽水平下降。然而,DMT可降低肺细胞凋亡、肺泡-间隔厚度、出血、血管充血和丙二醛水平,而肺组织中的谷胱甘肽水平升高。结论:本研究首次探讨了DMT对腹主动脉瘤破裂模型肺功能的影响。我们的研究结果表明,α -2肾上腺素能受体激动剂DMT可减少氧化应激和细胞凋亡,从而防止主动脉闭塞引起的肺损伤。
{"title":"Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury.","authors":"Dogus Hemsinli,&nbsp;Levent Tumkaya,&nbsp;Saban Ergene,&nbsp;S Ozan Karakisi,&nbsp;Tolga Mercantepe,&nbsp;Adnan Yilmaz","doi":"10.1080/10641963.2022.2093893","DOIUrl":"https://doi.org/10.1080/10641963.2022.2093893","url":null,"abstract":"<p><strong>Objective: </strong>Despite significant improvements in interventional vascular aneurysm repair procedures and intensive care patient management, there has been no significant decrease in mortality due to ruptured abdominal aortic aneurysm. Oxidative stress is known to play a key role in secondary organ damage due to infrarenal aortic clamping. The aim of this study was to examine the potential protective effect of the alpha-2 adrenergic receptor agonist dexmedetomidine (DMT) on aortic occlusion-induced lung injury.</p><p><strong>Methods: </strong>Thirty Sprague Dawley rats were allocated into control, ischemia-reperfusion (IR), and IR+DMT groups randomly. Vascular clamps were attached to the abdominal aorta in the IR and IR+DMT groups. Two-hour reperfusion was established 1 h after ischemia. The IR+DMT group received a single intraperitoneal 100 µg dose of DMT 30 min before infrarenal abdominal aortic clamping.</p><p><strong>Results: </strong>IR due to aortic occlusion led to apoptosis, widespread inflammation, alveolar septal wall thickening due to bleeding and vascular congestion were observed in both types I and II pneumocytes. Malondialdehyde levels increased while glutathione decreased. However, DMT was found to lower apoptotic pneumocytes, alveolar-septal thickness, hemorrhage, vascular congestion, and malondialdehyde levels, while glutathione levels in lung tissue increased.</p><p><strong>Conclusions: </strong>This study is the first to address the effects of DMT on the lung in a ruptured abdominal aortic aneurysm model. Our findings suggest that the alpha-2 adrenergic receptor agonist DMT reduces oxidative stress and apoptosis, thus protecting against aortic occlusion-induced pulmonary injury.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40471799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Comparing of the effects of sesame oil and rapeseed oil versus suet oil and animal butter on the reproductive system of male rats. 香油、菜籽油与板油、动物黄油对雄性大鼠生殖系统影响的比较。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-08-03 DOI: 10.1080/10641963.2022.2105348
Behrooz Yahyaei, Miromid Safari

Background: The aim of this study was to compare the effect of vegetable oils and animal oils on the reproductive system of male rats.

Methods: This study was a random and observational study conducted on 36 male rats with the age of 6 weeks weighing 200 ± 20 grams. Different groups were fed by sesame oil, suet oil, rapeseed oil and animal butter. The control group was fed by standard food used normally to feed animals in the laboratories. At the end of six weeks, testosterone level changes and weight changes were compared among different groups. Data were analyzed by SPSS-IBM version 16.

Result: Weight changes among groups did not show a dramatic statistical difference (P = .571 > 0.005). Average weight in control group was 202 and about the male rats fed by 10% of animal butter and by sesame oil were 206.5 and 99, respectively. Weight changes among groups were significant (P value = 0.005 > 0.0004). The average testosterone level in the control group was 2.4. This value in the different groups fed by 10% oils, the maximum was 12.2 and the minimum was 1.35 assigned to animal butter and rapeseed oil, respectively. So we concluded that using 10% of different oils causes an increase in testosterone level (P value = 0.001 > 0.05). The maximum testosterone level was 3.6 in the rapeseed 20% group and lowest 0.45 in the sesame 20% group.

Conclusion: We found that animal oil-containing diet has no significant harmful effect on male rat reproductive system in comparison with plant oils.

背景:本研究的目的是比较植物油和动物油对雄性大鼠生殖系统的影响。方法:采用随机观察方法,选取36只6周龄、体重200±20 g的雄性大鼠。各组分别饲喂香油、大食油、菜籽油和动物黄油。对照组饲喂实验室动物饲料标准食品。六周后,比较不同组的睾酮水平变化和体重变化。使用SPSS-IBM version 16对数据进行分析。结果:各组体重变化差异无统计学意义(P = 0.571 > 0.005)。对照组的平均体重为202,饲喂10%动物黄油和芝麻油的雄性大鼠平均体重分别为206.5和99。各组间体重变化显著(P值= 0.005 > 0.0004)。对照组平均睾酮水平为2.4。在饲喂10%油脂的各组中,动物油和菜籽油的最高值为12.2,最低值为1.35。因此,我们得出的结论是,使用10%的不同油导致睾酮水平升高(P值= 0.001 > 0.05)。油菜籽20%组睾酮水平最高为3.6,芝麻20%组最低为0.45。结论:与植物油相比,动物油对雄性大鼠生殖系统没有明显的有害影响。
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引用次数: 0
Rebound sign: a case report and review of literature. 反弹征:1例报告及文献回顾。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-07-25 DOI: 10.1080/10641963.2022.2102646
Yuehai Wang, Changpeng Zhai, Yuqiang Zhang, Guangyong Huang, Shengjun Ma

We reviewed previously reported imaging features of coronary air embolism. We also reported an unusual image 'rebound sign' of proximal coronary artery air embolism for the first time, that is, with the regular contraction and relaxation of the heart, the contrast medium near the embolus rebounds regularly, and the smooth gas-liquid boundary is alternately clear and blurred. We conclude that myocardial bridge plays a role in the formation of 'rebound sign.'Abbreviations: CAE: Coronary Air Embolism; CAG: Coronary Angiography; RCA: Right Coronary Artery; LCA: Left Coronary Artery; LAD: Left Anterior Descending Coronary Artery; LCX: Left Circumflex Artery; MB: Myocardial Bridge; STEMI: ST Segment Elevation Myocardial Infarction; TOE: Transesophageal Echocardiography.

我们回顾了先前报道的冠状动脉空气栓塞的影像学特征。我们也首次报道了冠状动脉近端空气栓塞的异常图像“反弹征象”,即随着心脏有规律的收缩舒张,栓子附近造影剂有规律地反弹,平滑的气液边界交替清晰和模糊。我们认为心肌桥在“反弹征”的形成中起作用。缩写:CAE:冠状动脉空气栓塞;CAG:冠状动脉造影;RCA:右冠状动脉;LCA:左冠状动脉;LAD:左冠状动脉前降支;LCX:左旋动脉;MB:心肌桥;STEMI: ST段抬高型心肌梗死;经食管超声心动图。
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引用次数: 0
Thymoquinone improved redox homeostasis in the heart and aorta of hypothyroid rats. 百里醌改善甲状腺功能减退大鼠心脏和主动脉氧化还原稳态。
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-08-09 DOI: 10.1080/10641963.2022.2108046
Yousef Baghcheghi, Farimah Beheshti, Fatemeh Seyedi, Mahmoud Hosseini, Mahdiyeh Hedayati-Moghadam

Objectives: Propylthiouracil (PTU) is a common drug that is used in medicine for treating hyperthyroidism. Furthermore, hypothyroidism can also be induced with PTU. Considering the antioxidant effects of thymoquinone (TMQ), this study was designed to find out whether TMQ could counteract the oxidative damage in the heart and aorta tissues induced by hypothyroidism in rats.

Methods: Animals were arranged into four groups: (1) Control, (2) PTU, (3) PTU-TMQ 5, and (4) PTU-TMQ 10. Hypothyroidism was induced in rats by giving 0.05% PTU in drinking water. PTU and TMQ (5 and 10 mg/kg, ip) treatments were done for 42 days. Finally, the animals were sacrificed and the serum of the rats was collected for thyroxine level assessment. The heart and aorta tissues were also removed for biochemical oxidative stress markers measurement.

Results: A lower serum thyroxine level was observed after PTU treatment compared to the control group. Hypothyroidism also was accompanied by a decrease of thiol content, and superoxide dismutase (SOD), and catalase (CAT) activities in the heart and aorta tissues while increased malondialdehyde (MDA). Furthermore, a significant reduction in oxidative damage was noted in the heart and aorta following the administration of TMQ (5 and 10 mg/kg) which was indicated by the reduction in MDA and improved activities of SOD, CAT, and thiol.

Conclusion: In this study, TMQ was found to improve oxidative damages in the heart and aorta tissues of hypothyroid rats.

目的:丙硫脲嘧啶(PTU)是治疗甲亢的常用药物。此外,PTU还可诱发甲状腺功能减退。考虑到百里醌(TMQ)的抗氧化作用,本研究旨在探讨TMQ是否能对抗甲状腺功能减退大鼠引起的心脏和主动脉组织氧化损伤。方法:将动物分为4组:(1)对照组,(2)PTU组,(3)PTU- tmq 5组,(4)PTU- tmq 10组。用0.05% PTU饮水诱导大鼠甲状腺功能减退。PTU和TMQ(5和10 mg/kg, ip)处理42 d。最后处死大鼠,采集血清测定甲状腺素水平。取心脏和主动脉组织进行生化氧化应激标志物测定。结果:PTU治疗后血清甲状腺素水平明显低于对照组。甲状腺功能减退还伴有心脏和主动脉组织中硫醇含量降低,超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性降低,丙二醛(MDA)升高。此外,在给予TMQ(5和10 mg/kg)后,心脏和主动脉的氧化损伤显著减少,这表明MDA减少,SOD、CAT和硫醇活性提高。结论:TMQ可改善甲状腺功能减退大鼠心脏和主动脉组织的氧化损伤。
{"title":"Thymoquinone improved redox homeostasis in the heart and aorta of hypothyroid rats.","authors":"Yousef Baghcheghi,&nbsp;Farimah Beheshti,&nbsp;Fatemeh Seyedi,&nbsp;Mahmoud Hosseini,&nbsp;Mahdiyeh Hedayati-Moghadam","doi":"10.1080/10641963.2022.2108046","DOIUrl":"https://doi.org/10.1080/10641963.2022.2108046","url":null,"abstract":"<p><strong>Objectives: </strong>Propylthiouracil (PTU) is a common drug that is used in medicine for treating hyperthyroidism. Furthermore, hypothyroidism can also be induced with PTU. Considering the antioxidant effects of thymoquinone (TMQ), this study was designed to find out whether TMQ could counteract the oxidative damage in the heart and aorta tissues induced by hypothyroidism in rats.</p><p><strong>Methods: </strong>Animals were arranged into four groups: (1) Control, (2) PTU, (3) PTU-TMQ 5, and (4) PTU-TMQ 10. Hypothyroidism was induced in rats by giving 0.05% PTU in drinking water. PTU and TMQ (5 and 10 mg/kg, ip) treatments were done for 42 days. Finally, the animals were sacrificed and the serum of the rats was collected for thyroxine level assessment. The heart and aorta tissues were also removed for biochemical oxidative stress markers measurement.</p><p><strong>Results: </strong>A lower serum thyroxine level was observed after PTU treatment compared to the control group. Hypothyroidism also was accompanied by a decrease of thiol content, and superoxide dismutase (SOD), and catalase (CAT) activities in the heart and aorta tissues while increased malondialdehyde (MDA). Furthermore, a significant reduction in oxidative damage was noted in the heart and aorta following the administration of TMQ (5 and 10 mg/kg) which was indicated by the reduction in MDA and improved activities of SOD, CAT, and thiol.</p><p><strong>Conclusion: </strong>In this study, TMQ was found to improve oxidative damages in the heart and aorta tissues of hypothyroid rats.</p>","PeriodicalId":10333,"journal":{"name":"Clinical and Experimental Hypertension","volume":null,"pages":null},"PeriodicalIF":12.3,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40612997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between inflammatory cells level and longer duration of hypertension in Chinese community residents. 中国社区居民炎症细胞水平与高血压病程延长的关系
IF 12.3 4区 医学 Q3 Medicine Pub Date : 2022-10-03 Epub Date: 2022-07-15 DOI: 10.1080/10641963.2022.2100411
Yue Yi, Ting Qu, Aibin Shi, Zhixin Pang, Yuxin Zhao, Pengcheng Li, Juan Xie, Xinyue Zhi, Yun Zhu, Hong Zhu

Background: To explore the relationship between duration of hypertension and inflammatory cell levels and to assess whether long duration might aggravate these inflammatory cells among Chinese urban community residents.

Methods: A cross-sectional study of 5199 hypertensive and 2675 no-hypertensive participants who registered in community health service centers for physical examination was performed in Tianjin, China. Data of blood pressure and inflammatory cells were collected. Binary logistic regression was performed to assess the effect of hypertensive duration on the level of inflammatory cells before and after adjustment for the potential confounding factors.

Results: Individuals with hypertension had significantly higher level of leukocyte count, neutrophil proportion, neutrophil-to-lymphocyte ratio (NLR), and lower level of lymphocyte proportion than those without hypertension. Two-way ANOVA showed that hypertension duration, rather than blood pressure control or their interaction, had significant influence on the levels of neutrophil proportion, lymphocyte proportion, and NLR. With the prolongation of the duration of hypertension, the level of neutrophil proportion and NLR increased, and the level of lymphocyte proportion decreased. Long hypertension duration (>10 years) was significantly associated with high level of neutrophil proportion (OR = 1.48, 95% CI: 1.25, 1.75), high level of NLR (OR = 1.53, 95% CI: 1.29, 1.81), and low level of lymphocyte proportion (OR = 1.54, 95% CI: 1.30, 1.82) in comparison with short duration (<5 years) after adjustment for confounding factors.

Conclusion: Hypertensive patients had higher level of leukocyte count, neutrophil proportion, NLR, and lower level of lymphocyte proportion than normotensive ones. Long duration of hypertension was associated with aggravated inflammatory biomarkers.

背景:探讨中国城市社区居民高血压病程与炎症细胞水平的关系,并评估长期高血压病程是否会加重这些炎症细胞。方法:对在天津市社区卫生服务中心登记体检的5199名高血压患者和2675名无高血压患者进行横断面研究。采集血压和炎症细胞数据。采用二元logistic回归来评估高血压持续时间对校正潜在混杂因素前后炎症细胞水平的影响。结果:高血压患者白细胞计数、中性粒细胞比例、中性粒细胞与淋巴细胞比值(NLR)明显高于无高血压者,淋巴细胞比例明显低于无高血压者。双向方差分析显示,高血压持续时间对中性粒细胞比例、淋巴细胞比例和NLR水平有显著影响,而不是血压控制或两者的相互作用。随着高血压病程的延长,中性粒细胞比例和NLR水平升高,淋巴细胞比例水平降低。高血压病程长(>10年)与病程短相比,中性粒细胞比例高(OR = 1.48, 95% CI: 1.25, 1.75)、NLR高(OR = 1.53, 95% CI: 1.29, 1.81)、淋巴细胞比例低(OR = 1.54, 95% CI: 1.30, 1.82)显著相关(结论:高血压患者白细胞计数、中性粒细胞比例、NLR水平较高,淋巴细胞比例较低)。高血压持续时间长与炎症生物标志物加重有关。
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引用次数: 2
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Clinical and Experimental Hypertension
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