{"title":"Large cellulitis-like erythematous plaques with overlying nodules on bilateral shins.","authors":"Ping-Chen Hou, Julia Yu-Yun Lee, Chao-Chun Yang","doi":"10.1111/ddg.70027","DOIUrl":"https://doi.org/10.1111/ddg.70027","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophia Neisinger, Thomas Buttgereit, Torsten Zuberbier, Markus Magerl
{"title":"Google searches show persistent use of outdated terminology for angioedema in Germany.","authors":"Sophia Neisinger, Thomas Buttgereit, Torsten Zuberbier, Markus Magerl","doi":"10.1111/ddg.70278","DOIUrl":"https://doi.org/10.1111/ddg.70278","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of Varicella in Pregnancy: overview of the current literature based on two patient cases.","authors":"Hannah P Hannert, Robert R Müllegger","doi":"10.1111/ddg.70315","DOIUrl":"https://doi.org/10.1111/ddg.70315","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Should TNF inhibitors be avoided in psoriasis patients with latent tuberculosis?","authors":"Fabià Torres-Betato, Lluís Puig","doi":"10.1111/ddg.70287","DOIUrl":"https://doi.org/10.1111/ddg.70287","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-08Epub Date: 2025-09-30DOI: 10.1111/ddg.15897
Patrick Schummer, Caroline Glatzel, Philipp Schrüfer, Ingulf Lawrenz, Gabor Dobos, Ulrike Wehkamp, Svea Hüning, René Stranzenbach, Jan P. Nicolay, Matthias Goebeler, Marion Wobser
Background and Objectives
While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30-positive cutaneous T-cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy and tolerability remain scarce. In this retrospective analysis, we evaluated the combination of BV and RTx in patients with CD30-positive CTCL.
Patients and Methods
We included 14 CD30-positive CTCL patients from six German cancer centers receiving BV; RTx was initiated within a timeframe of 3 months prior/after BV treatment. RTx was mainly applied as a low-dose scheme.
Results
Adverse events of any grade occurred in 71% of patients, most commonly peripheral neuropathy, neutropenia, and radiodermatitis. Thirteen patients achieved a complete or partial remission as best overall response, however, 50% of all patients showed disease progression. At a median follow-up of 14.4 months, median progression-free survival was 12.0 months, with a 1-year rate of 34.0%.
Conclusions
The simultaneous or sequential use of RTx during BV treatment was feasible and well tolerated. Future randomized investigations are needed to identify the benefits of this combination treatment regimen as well as adequate dosing of BV and RTx in a prospective manner.
{"title":"Brentuximab vedotin and radiotherapy for CD30-positive cutaneous T-cell lymphoma – a retrospective multicenter analysis","authors":"Patrick Schummer, Caroline Glatzel, Philipp Schrüfer, Ingulf Lawrenz, Gabor Dobos, Ulrike Wehkamp, Svea Hüning, René Stranzenbach, Jan P. Nicolay, Matthias Goebeler, Marion Wobser","doi":"10.1111/ddg.15897","DOIUrl":"10.1111/ddg.15897","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Objectives</h3>\u0000 \u0000 <p>While brentuximab vedotin (BV) and radiotherapy (RTx) are established treatment options for CD30-positive cutaneous T-cell lymphoma (CTCL), data on their simultaneous or sequential use regarding efficacy and tolerability remain scarce. In this retrospective analysis, we evaluated the combination of BV and RTx in patients with CD30-positive CTCL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>We included 14 CD30-positive CTCL patients from six German cancer centers receiving BV; RTx was initiated within a timeframe of 3 months prior/after BV treatment. RTx was mainly applied as a low-dose scheme.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Adverse events of any grade occurred in 71% of patients, most commonly peripheral neuropathy, neutropenia, and radiodermatitis. Thirteen patients achieved a complete or partial remission as best overall response, however, 50% of all patients showed disease progression. At a median follow-up of 14.4 months, median progression-free survival was 12.0 months, with a 1-year rate of 34.0%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The simultaneous or sequential use of RTx during BV treatment was feasible and well tolerated. Future randomized investigations are needed to identify the benefits of this combination treatment regimen as well as adequate dosing of BV and RTx in a prospective manner.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"24 4","pages":"495-502"},"PeriodicalIF":3.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-08Epub Date: 2025-11-19DOI: 10.1111/ddg.15987
Theng Chun Wong, Zachary Holmes, Francis Yi Xing Lai, Adrian Mar, Senhong Lee
{"title":"A case of Morbihan syndrome successfully treated with high dose omalizumab","authors":"Theng Chun Wong, Zachary Holmes, Francis Yi Xing Lai, Adrian Mar, Senhong Lee","doi":"10.1111/ddg.15987","DOIUrl":"10.1111/ddg.15987","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"24 4","pages":"541-543"},"PeriodicalIF":3.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-04-08Epub Date: 2025-11-20DOI: 10.1111/ddg.15864
Marija Geroldinger-Simić, Ana E. Aguilar González, Gerald Exler, Georg Stary
Background and objectives
Systemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis of the skin and/or internal organs. Emerging evidence suggests that subcutaneous adipose tissue may contribute to systemic inflammation and fibrosis in SSc. This study aimed to conduct a comprehensive analysis of immune cell composition in SSc by simultaneously examining blood, skin, and subcutaneous adipose tissue.
Patients and Methods
Using spectral flow cytometry, we profiled major immune cell subsets and explored their associations with clinical features of SSc.
Results
Patients with mild skin fibrosis (low mRSS) exhibited increased cDC1, moDC, and ThGM-CSF cells in the skin, alongside with an influx of Th22 cells and reduced terminal NK cells in subcutaneous adipose tissue. In SSc patients with lung fibrosis, peripheral blood showed decreased NK cells and increased CD8+ T cells. Anti-Scl-70-positive patients demonstrated elevated CD8+ effector T cells, whereas anti-centromere-positive patients showed increased ThGM-CSF cells in the skin.
Conclusions
These findings highlight the potential role of distinct immune subsets for disease progression and tissue-specific fibrosis in SSc.
{"title":"Immune cells composition in the skin and subcutaneous adipose tissue of patients with systemic sclerosis","authors":"Marija Geroldinger-Simić, Ana E. Aguilar González, Gerald Exler, Georg Stary","doi":"10.1111/ddg.15864","DOIUrl":"10.1111/ddg.15864","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and objectives</h3>\u0000 \u0000 <p>Systemic sclerosis (SSc) is a rare, chronic autoimmune disease characterized by fibrosis of the skin and/or internal organs. Emerging evidence suggests that subcutaneous adipose tissue may contribute to systemic inflammation and fibrosis in SSc. This study aimed to conduct a comprehensive analysis of immune cell composition in SSc by simultaneously examining blood, skin, and subcutaneous adipose tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>Using spectral flow cytometry, we profiled major immune cell subsets and explored their associations with clinical features of SSc.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with mild skin fibrosis (low mRSS) exhibited increased cDC1, moDC, and ThGM-CSF cells in the skin, alongside with an influx of Th22 cells and reduced terminal NK cells in subcutaneous adipose tissue. In SSc patients with lung fibrosis, peripheral blood showed decreased NK cells and increased CD8<sup>+</sup> T cells. Anti-Scl-70-positive patients demonstrated elevated CD8<sup>+</sup> effector T cells, whereas anti-centromere-positive patients showed increased ThGM-CSF cells in the skin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings highlight the potential role of distinct immune subsets for disease progression and tissue-specific fibrosis in SSc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"24 4","pages":"482-492"},"PeriodicalIF":3.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13059067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oliver Brandt, Erere Otrofanowei, Ncoza Dlova, Simon M. Mueller
{"title":"Die vernachlässigte Mehrheit: Inverse Beziehung zwischen Prävalenz und globaler Forschungsaktivität bei 15 dermatologischen Krankheiten","authors":"Oliver Brandt, Erere Otrofanowei, Ncoza Dlova, Simon M. Mueller","doi":"10.1111/ddg.15885_g","DOIUrl":"https://doi.org/10.1111/ddg.15885_g","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"24 4","pages":"538-540"},"PeriodicalIF":3.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Domänenwechsel als Lackmustest – zur Robustheit KI-basierter Bilddiagnostik in der Dermatologie","authors":"Alexander Zink","doi":"10.1111/ddg.70281","DOIUrl":"https://doi.org/10.1111/ddg.70281","url":null,"abstract":"","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":"24 4","pages":"445-446"},"PeriodicalIF":3.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sandra Schuh, Stefan Schiele, Anna Rubeck, Ludwig Christian Hinske, Julia Welzel, Alexander Schneller
Background: Realistic and accessible models are essential for training physicians in clinical procedures. This study investigated whether a cost-effective 3D-printed skin model is superior to fruit and foam models for teaching skin biopsies.
Patients and methods: The study (10/2023-02/2025) involved 148 medical students who compared the 3D skin model, made of soft silicone, shore hardness 10-A, with fruit and foam for punch biopsy training. Previous cohorts used only fruit and foam. 28 physicians assessed realism of the 3D model versus real skin. Practical skills were evaluated in Objective Structured Clinical Examinations (OSCEs), and feedback from students and physicians was collected via standardized questionnaires. Economic and ecological impacts were analyzed.
Results: Students rated the 3D skin model significantly higher for realism and training suitability than fruit and foam (p < 0.001). OSCE scores indicated comparable skill acquisition (p = 0.2005). Physicians found the 3D model more anatomically and haptically realistic than foam and fruit (each p < 0.001).
Conclusions: The 3D-printed skin model is a superior, cost-effective training tool that overcomes limitations of traditional models, improves confidence, and enhances skill acquisition. Although production is resource-intensive, its reusability and low-cost materials make it sustainable. Anatomical realism fosters interest in dermatology, making it a promising innovation in medical education.
{"title":"Comparison of a 3D-printed skin model with established methods for teaching punch biopsy with suturing.","authors":"Sandra Schuh, Stefan Schiele, Anna Rubeck, Ludwig Christian Hinske, Julia Welzel, Alexander Schneller","doi":"10.1111/ddg.70067","DOIUrl":"https://doi.org/10.1111/ddg.70067","url":null,"abstract":"<p><strong>Background: </strong>Realistic and accessible models are essential for training physicians in clinical procedures. This study investigated whether a cost-effective 3D-printed skin model is superior to fruit and foam models for teaching skin biopsies.</p><p><strong>Patients and methods: </strong>The study (10/2023-02/2025) involved 148 medical students who compared the 3D skin model, made of soft silicone, shore hardness 10-A, with fruit and foam for punch biopsy training. Previous cohorts used only fruit and foam. 28 physicians assessed realism of the 3D model versus real skin. Practical skills were evaluated in Objective Structured Clinical Examinations (OSCEs), and feedback from students and physicians was collected via standardized questionnaires. Economic and ecological impacts were analyzed.</p><p><strong>Results: </strong>Students rated the 3D skin model significantly higher for realism and training suitability than fruit and foam (p < 0.001). OSCE scores indicated comparable skill acquisition (p = 0.2005). Physicians found the 3D model more anatomically and haptically realistic than foam and fruit (each p < 0.001).</p><p><strong>Conclusions: </strong>The 3D-printed skin model is a superior, cost-effective training tool that overcomes limitations of traditional models, improves confidence, and enhances skill acquisition. Although production is resource-intensive, its reusability and low-cost materials make it sustainable. Anatomical realism fosters interest in dermatology, making it a promising innovation in medical education.</p>","PeriodicalId":14758,"journal":{"name":"Journal Der Deutschen Dermatologischen Gesellschaft","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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