Pub Date : 2025-06-30DOI: 10.18413/2658-6533-2025-11-2-0-1
Bordaeva, O.Y., Alayasa, N.I., Zezerova, Yu.S., Milutina, N.P., Derevyanchuk, E.G.
Background: Preeclampsia (PE) is a pregnancy-related condition linked to hypertension and proteinuria.It is a major cause of maternal and perinatal mortality.The aim of the study: The aim of this study was to investigate the effect of PE on blood parameters and to assess its diagnostic significance.It also investigated the association between renin-angiotensin system gene polymorphisms and susceptibility to PE. Materials and methods: We studied 40 pregnant women aged 25 to 40 years (10 with normal pregnancy, 10 with mild PE, 10 with moderate PE, and 10 with severe PE).We measured alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, creatinine, and total protein levels in both normal and preeclamptic pregnancies.Furthermore, we genotyped 40 preeclamptic women and 60 normotensive pregnant controls for renin-angiotensin system gene polymorphisms.Multifactor dimensionality reduction (MDR) was carried out to assess the interactions among these polymorphisms.Results: The activity of ALT, AST, and ALP significantly increased in PE groups (mild, moderate, severe) compared to the control group (p=0.008-0.00001).Urea level significantly increased in severe PE (p=0.038).Creatinine levels increased significantly in moderate and severe PE (p=0.00004-0.00001),while total protein levels decreased significantly in all PE groups compared to the control group (p=0.001-0.00005).We also found that the T allele of the AGT (C521T; Thr174Met; rs4762) polymorphism was significantly associated with the risk of PE (p=0.005), and the TT genotype was also significant but not associated with increased risk of PE (p=0.034).The best MDR model was the four-factor model with a test balance accuracy of 0.546 and a maximum cross-validation consistency of 10/10 (p<0.0001).Conclusion: Preeclamptic pregnancies had elevated ALT, AST, ALP, serum urea, serum creatinine, and reduced total protein levels.In addition, the AGT (C521T; Thr174Met; rs4762) polymorphism was associated with PE risk.Furthermore, the four-factors MDR model was highly informative and associated with PE risk (p<0.0001).
{"title":"Clinic-laboratory blood parameters and the contribution of reninangiotensin system gene polymorphisms in pregnant women with preeclampsia","authors":"Bordaeva, O.Y., Alayasa, N.I., Zezerova, Yu.S., Milutina, N.P., Derevyanchuk, E.G.","doi":"10.18413/2658-6533-2025-11-2-0-1","DOIUrl":"https://doi.org/10.18413/2658-6533-2025-11-2-0-1","url":null,"abstract":"Background: Preeclampsia (PE) is a pregnancy-related condition linked to hypertension and proteinuria.It is a major cause of maternal and perinatal mortality.The aim of the study: The aim of this study was to investigate the effect of PE on blood parameters and to assess its diagnostic significance.It also investigated the association between renin-angiotensin system gene polymorphisms and susceptibility to PE. Materials and methods: We studied 40 pregnant women aged 25 to 40 years (10 with normal pregnancy, 10 with mild PE, 10 with moderate PE, and 10 with severe PE).We measured alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, creatinine, and total protein levels in both normal and preeclamptic pregnancies.Furthermore, we genotyped 40 preeclamptic women and 60 normotensive pregnant controls for renin-angiotensin system gene polymorphisms.Multifactor dimensionality reduction (MDR) was carried out to assess the interactions among these polymorphisms.Results: The activity of ALT, AST, and ALP significantly increased in PE groups (mild, moderate, severe) compared to the control group (p=0.008-0.00001).Urea level significantly increased in severe PE (p=0.038).Creatinine levels increased significantly in moderate and severe PE (p=0.00004-0.00001),while total protein levels decreased significantly in all PE groups compared to the control group (p=0.001-0.00005).We also found that the T allele of the AGT (C521T; Thr174Met; rs4762) polymorphism was significantly associated with the risk of PE (p=0.005), and the TT genotype was also significant but not associated with increased risk of PE (p=0.034).The best MDR model was the four-factor model with a test balance accuracy of 0.546 and a maximum cross-validation consistency of 10/10 (p<0.0001).Conclusion: Preeclamptic pregnancies had elevated ALT, AST, ALP, serum urea, serum creatinine, and reduced total protein levels.In addition, the AGT (C521T; Thr174Met; rs4762) polymorphism was associated with PE risk.Furthermore, the four-factors MDR model was highly informative and associated with PE risk (p<0.0001).","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://rrmedicine.ru/journal/download/3766","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-9
Ruslan E. Osmanov, Vitaly V. Aksenov
{"title":"Prevalence of clinical geriatric syndromes in cataract patients","authors":"Ruslan E. Osmanov, Vitaly V. Aksenov","doi":"10.18413/2658-6533-2023-9-2-0-9","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-9","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"540 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79386031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-10
N. Rzhevskaya, K. Retyunskiy, I. S. Khamskaya, Ksenia N. Shvets, V. Ruzhenkova
{"title":"Clinical and psychopathological features and psychopharmacotherapy of patients with the first episode of schizophrenia hospitalized in a psychiatric hospital with and without voluntary consent","authors":"N. Rzhevskaya, K. Retyunskiy, I. S. Khamskaya, Ksenia N. Shvets, V. Ruzhenkova","doi":"10.18413/2658-6533-2023-9-2-0-10","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-10","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88799861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-5
F. Datieva, Z. Dzampaeva, E. Takoeva, Varina I. Nartikoeva
{"title":"Effects of complex phytoadaptogens in matobolic syndrome","authors":"F. Datieva, Z. Dzampaeva, E. Takoeva, Varina I. Nartikoeva","doi":"10.18413/2658-6533-2023-9-2-0-5","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-5","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"273 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76783003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-4
V. Novakov, O. Novakova, I. Sorokina, I. Batlutskaya, O. Efremova, V. Orlova
{"title":"Genetic markers of knee osteoarthritis in women of the Central Chernozem region of Russia","authors":"V. Novakov, O. Novakova, I. Sorokina, I. Batlutskaya, O. Efremova, V. Orlova","doi":"10.18413/2658-6533-2023-9-2-0-4","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-4","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87941174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-2
A. H. Albosale, E. V. Mashkina
{"title":"Association between mitochondrial DNA copy number and high viral load in women with high-risk human papillomavirus","authors":"A. H. Albosale, E. V. Mashkina","doi":"10.18413/2658-6533-2023-9-2-0-2","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-2","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75412982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-7
S. Shamarin, Еlena V. Enkova, Lyudmila I. Ippolitova, Еlena V. Kiseleva, O. V. Khoperskaya, Alexander D. Chernykh
{"title":"Doppler fetal monitoring and non-invasive fetal ECG in modern obstetrics (review)","authors":"S. Shamarin, Еlena V. Enkova, Lyudmila I. Ippolitova, Еlena V. Kiseleva, O. V. Khoperskaya, Alexander D. Chernykh","doi":"10.18413/2658-6533-2023-9-2-0-7","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-7","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76233408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-6
Dmitry I. Pisare, N. Boyko, K. S. Nikitin, Y. Vatnikov, A. Karamyan, V. Semenova, A. Malyutina, V. I. Kuznetsov, K. M. Sakanyan, O. Novikov
{"title":"Pharmacological potential of ar-turmerone and study of the extractive potential of fluorinated alkane derivatives for its isolation from the rhizomes of Curcuma longa L.","authors":"Dmitry I. Pisare, N. Boyko, K. S. Nikitin, Y. Vatnikov, A. Karamyan, V. Semenova, A. Malyutina, V. I. Kuznetsov, K. M. Sakanyan, O. Novikov","doi":"10.18413/2658-6533-2023-9-2-0-6","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-6","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75321647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-8
O. Osipova, R. Shepel, K. G. Plaksina, Yury A. Mezentsev, Victor A. Negrebetsky, V. S. Pribylov
{"title":"Cognitive function of elderly and senile patients on the background of long-term pharmacotherapy of chronic heart failure with low ejection fraction","authors":"O. Osipova, R. Shepel, K. G. Plaksina, Yury A. Mezentsev, Victor A. Negrebetsky, V. S. Pribylov","doi":"10.18413/2658-6533-2023-9-2-0-8","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-8","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84177273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-30DOI: 10.18413/2658-6533-2023-9-2-0-3
A. Kazantseva, R. Enikeeva, A. Toropova, Ilya M. Zakharov, V. Ismatullina, E. Khusnutdinova, S. Malykh
{"title":"A replication study of genetic variants associated with high-level musical aptitude","authors":"A. Kazantseva, R. Enikeeva, A. Toropova, Ilya M. Zakharov, V. Ismatullina, E. Khusnutdinova, S. Malykh","doi":"10.18413/2658-6533-2023-9-2-0-3","DOIUrl":"https://doi.org/10.18413/2658-6533-2023-9-2-0-3","url":null,"abstract":"","PeriodicalId":20921,"journal":{"name":"RESEARCH RESULTS IN BIOMEDICINE","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89942423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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