Pub Date : 2025-02-12DOI: 10.1016/j.resuscitation.2025.110539
Federico Semeraro, Sebastian Schnaubelt, Jonathan Montomoli, Elena Giovanna Bignami, Koenraad G Monsieurs
{"title":"Artificial Intelligence in cardiopulmonary resuscitation: Driving awareness and debunking myths.","authors":"Federico Semeraro, Sebastian Schnaubelt, Jonathan Montomoli, Elena Giovanna Bignami, Koenraad G Monsieurs","doi":"10.1016/j.resuscitation.2025.110539","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110539","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110539"},"PeriodicalIF":6.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-12DOI: 10.1016/j.resuscitation.2025.110537
June-Sung Kim, Youn-Jung Kim, Seok In Hong, Sang-Min Kim, Bora Chae, Seung Mok Ryoo, Won Young Kim
Background: The optimal targets for diastolic blood pressure (DBP) and end-tidal carbon dioxide (ETCO2) during cardiopulmonary resuscitation (CPR) and their association with outcomes remain unclear. This study aimed to evaluate the association between DBP and ETCO2 and the return of spontaneous circulation (ROSC) during CPR.
Methods: This study was a preplanned sub-analysis of the Augmented Medication CardioPulmonary Resuscitation (AMCPR) trial. We extracted initial (within 5 minutes), follow-up (around 10 minutes), and delta (follow-up minus initial) values of DBP and ETCO2 from the registry. The primary outcome was sustained ROSC (≥20 minutes).
Results: The study included 264 patients, mostly male (69.3%) and with a median age of 74 years old. Of these patients, 101 (38.3%) achieved sustained ROSC. Patients with sustained ROSC had statistically higher initial, follow-up, and delta values of DBP compared to those without ROSC. However, the levels of ETCO2 were similar between the two groups, except for follow-up values. Follow-up DBP above 26.5 and delta DBP above 6.5 were independently associated with sustained ROSC (adjusted odds ratio, aOR = 10.03, 95% confidence interval, CI = 3.64 - 27.66, p < 0.01, and aOR = 4.83, 95% CI = 1.90 - 12.26, p < 0.01).
Conclusion: Monitoring DBP during resuscitation in patients with cardiac arrest may provide additional information about successful initial resuscitation. Improving certain levels of DBP may influence outcomes.
{"title":"Diastolic blood pressures and end tidal carbon dioxides during cardiopulmonary resuscitations and their association with outcomes in adult out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the Augmented Medication CardioPulmonary Resuscitation (AMCPR) trial.","authors":"June-Sung Kim, Youn-Jung Kim, Seok In Hong, Sang-Min Kim, Bora Chae, Seung Mok Ryoo, Won Young Kim","doi":"10.1016/j.resuscitation.2025.110537","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110537","url":null,"abstract":"<p><strong>Background: </strong>The optimal targets for diastolic blood pressure (DBP) and end-tidal carbon dioxide (ETCO2) during cardiopulmonary resuscitation (CPR) and their association with outcomes remain unclear. This study aimed to evaluate the association between DBP and ETCO2 and the return of spontaneous circulation (ROSC) during CPR.</p><p><strong>Methods: </strong>This study was a preplanned sub-analysis of the Augmented Medication CardioPulmonary Resuscitation (AMCPR) trial. We extracted initial (within 5 minutes), follow-up (around 10 minutes), and delta (follow-up minus initial) values of DBP and ETCO2 from the registry. The primary outcome was sustained ROSC (≥20 minutes).</p><p><strong>Results: </strong>The study included 264 patients, mostly male (69.3%) and with a median age of 74 years old. Of these patients, 101 (38.3%) achieved sustained ROSC. Patients with sustained ROSC had statistically higher initial, follow-up, and delta values of DBP compared to those without ROSC. However, the levels of ETCO2 were similar between the two groups, except for follow-up values. Follow-up DBP above 26.5 and delta DBP above 6.5 were independently associated with sustained ROSC (adjusted odds ratio, aOR = 10.03, 95% confidence interval, CI = 3.64 - 27.66, p < 0.01, and aOR = 4.83, 95% CI = 1.90 - 12.26, p < 0.01).</p><p><strong>Conclusion: </strong>Monitoring DBP during resuscitation in patients with cardiac arrest may provide additional information about successful initial resuscitation. Improving certain levels of DBP may influence outcomes.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110537"},"PeriodicalIF":6.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-12DOI: 10.1016/j.resuscitation.2025.110541
Federico Semeraro, Kaushila Thilakasiri, Sebastian Schnaubelt, Bernd W Böttiger
{"title":"Progress and challenges in implementing \"Kids Save Lives\" across Europe in 2025.","authors":"Federico Semeraro, Kaushila Thilakasiri, Sebastian Schnaubelt, Bernd W Böttiger","doi":"10.1016/j.resuscitation.2025.110541","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110541","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110541"},"PeriodicalIF":6.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-12DOI: 10.1016/j.resuscitation.2025.110540
Federico Semeraro, Nino Fijačko, Lorenzo Gamberini, Elena Giovanna Bignami, Robert Greif
{"title":"The gap between promise and reality: Evaluating new AI's role in CPR education.","authors":"Federico Semeraro, Nino Fijačko, Lorenzo Gamberini, Elena Giovanna Bignami, Robert Greif","doi":"10.1016/j.resuscitation.2025.110540","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110540","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110540"},"PeriodicalIF":6.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-11DOI: 10.1016/j.resuscitation.2025.110534
Georg Gelbenegger, Sheldon Cheskes, Bernd Jilma, Markus Zeitlinger, Steve Lin, Ian R Drennan, Anselm Jorda
Background: Amiodarone is used in shockable out-of-hospital cardiac arrest (OHCA), but the ideal dose is unknown.
Methods: This was an analysis from the Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry (2011-2015). Patients with shockable OHCA who received 5 or more defibrillation attempts and treatment with 300 or 450 mg of amiodarone were included. Outcomes were ROSC at ED arrival, survival at hospital discharge, and favorable neurologic function at discharge. Group-differences were adjusted for using inverse probability weighting and a multiple logistic regression model.
Results: The present study included 910 patients; 426 received amiodarone 300 mg and 484 received amiodarone 450 mg. The amiodarone 300 mg group had a higher estimated probability of ROSC at ED arrival as compared with the amiodarone 450 mg group (30.8% [95% CI, 26.6-35.1] vs 24.2% [95% CI, 20.5-27.9], respectively; adjusted probability difference, 6.6% (0.9-12.3), p=0.0234). The group differences in survival at hospital discharge (21.3% [95% CI, 17.2-25.4] vs 18.0% [95% CI, 14.6-21.5]; adjusted probability difference, 3.3% [-2.3-8.8]) and favorable neurologic outcome at discharge (16.5% [95% CI, 12.9-20.2] vs 12.7% [95% CI, 9.5-16.0]; adjusted probability difference, 3.8% [95% CI, -1.2-8.7]) did not reach statistical significance.
Conclusion: In patients with shockable OHCA who received 5 or more defibrillation attempts, a dose of amiodarone 300 mg was associated with a similar survival compared with a total dose of amiodarone 450 mg. Further study is needed to evaluate the need for a second administration of amiodarone in patients with shockable OHCA.
{"title":"Amiodarone dose in patients with shockable out-of-hospital cardiac arrest.","authors":"Georg Gelbenegger, Sheldon Cheskes, Bernd Jilma, Markus Zeitlinger, Steve Lin, Ian R Drennan, Anselm Jorda","doi":"10.1016/j.resuscitation.2025.110534","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110534","url":null,"abstract":"<p><strong>Background: </strong>Amiodarone is used in shockable out-of-hospital cardiac arrest (OHCA), but the ideal dose is unknown.</p><p><strong>Methods: </strong>This was an analysis from the Resuscitation Outcomes Consortium Cardiac Epidemiologic Registry (2011-2015). Patients with shockable OHCA who received 5 or more defibrillation attempts and treatment with 300 or 450 mg of amiodarone were included. Outcomes were ROSC at ED arrival, survival at hospital discharge, and favorable neurologic function at discharge. Group-differences were adjusted for using inverse probability weighting and a multiple logistic regression model.</p><p><strong>Results: </strong>The present study included 910 patients; 426 received amiodarone 300 mg and 484 received amiodarone 450 mg. The amiodarone 300 mg group had a higher estimated probability of ROSC at ED arrival as compared with the amiodarone 450 mg group (30.8% [95% CI, 26.6-35.1] vs 24.2% [95% CI, 20.5-27.9], respectively; adjusted probability difference, 6.6% (0.9-12.3), p=0.0234). The group differences in survival at hospital discharge (21.3% [95% CI, 17.2-25.4] vs 18.0% [95% CI, 14.6-21.5]; adjusted probability difference, 3.3% [-2.3-8.8]) and favorable neurologic outcome at discharge (16.5% [95% CI, 12.9-20.2] vs 12.7% [95% CI, 9.5-16.0]; adjusted probability difference, 3.8% [95% CI, -1.2-8.7]) did not reach statistical significance.</p><p><strong>Conclusion: </strong>In patients with shockable OHCA who received 5 or more defibrillation attempts, a dose of amiodarone 300 mg was associated with a similar survival compared with a total dose of amiodarone 450 mg. Further study is needed to evaluate the need for a second administration of amiodarone in patients with shockable OHCA.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110534"},"PeriodicalIF":6.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-11DOI: 10.1016/j.resuscitation.2025.110536
Falk Eckart, Maxi Kaufmann, Lars Mense, Mario Rüdiger
Background: Each year, millions of neonates require supportive interventions in the delivery room (DR) during the transition from intrauterine to extrauterine life. Resuscitation guidelines are critical for healthcare providers managing these neonates and rely on current evidence of real-world DR management. However, data on the actual frequency of various supportive interventions are often limited, focused on single centers or outdated. This study aims to describe the current practice of neonatal resuscitation and support in the DR and to provide evidence for the development of clinical guidelines.
Methods: This prospective, international, multicenter observational study collected data from 68 hospitals in 19 countries over a 6-month period. Pre-defined supportive interventions administered to neonates of all gestational ages within the first 30 minutes of life were recorded. Additionally, structural hospital characteristics and patient characteristics of supported neonates were documented.
Results: Approximately 11.1% of the 74,183 neonates born during the observation period received relevant supportive interventions. The most common interventions were continuous positive airway pressure (CPAP), oxygen supplementation, and suctioning. Less common interventions included epinephrine administration, intraosseous access and laryngeal mask application. Intervention frequencies varied considerably between hospitals and countries.
Conclusions: This study provides comprehensive data on the use of supportive interventions in neonatal resuscitation from different countries around the world. The findings can inform the development of future resuscitation guidelines and training programs. In addition, the data highlight the need for improved dissemination of evidence-based practices to ensure consistent and optimal care for neonates in the DR.
{"title":"Descriptive dataset analysis of a Survey on Currently applied Interventions in Neonatal resuscitation (SCIN).","authors":"Falk Eckart, Maxi Kaufmann, Lars Mense, Mario Rüdiger","doi":"10.1016/j.resuscitation.2025.110536","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110536","url":null,"abstract":"<p><strong>Background: </strong>Each year, millions of neonates require supportive interventions in the delivery room (DR) during the transition from intrauterine to extrauterine life. Resuscitation guidelines are critical for healthcare providers managing these neonates and rely on current evidence of real-world DR management. However, data on the actual frequency of various supportive interventions are often limited, focused on single centers or outdated. This study aims to describe the current practice of neonatal resuscitation and support in the DR and to provide evidence for the development of clinical guidelines.</p><p><strong>Methods: </strong>This prospective, international, multicenter observational study collected data from 68 hospitals in 19 countries over a 6-month period. Pre-defined supportive interventions administered to neonates of all gestational ages within the first 30 minutes of life were recorded. Additionally, structural hospital characteristics and patient characteristics of supported neonates were documented.</p><p><strong>Results: </strong>Approximately 11.1% of the 74,183 neonates born during the observation period received relevant supportive interventions. The most common interventions were continuous positive airway pressure (CPAP), oxygen supplementation, and suctioning. Less common interventions included epinephrine administration, intraosseous access and laryngeal mask application. Intervention frequencies varied considerably between hospitals and countries.</p><p><strong>Conclusions: </strong>This study provides comprehensive data on the use of supportive interventions in neonatal resuscitation from different countries around the world. The findings can inform the development of future resuscitation guidelines and training programs. In addition, the data highlight the need for improved dissemination of evidence-based practices to ensure consistent and optimal care for neonates in the DR.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110536"},"PeriodicalIF":6.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-11DOI: 10.1016/j.resuscitation.2025.110535
Tomoaki Aoki, Yusuke Endo, Tai Yin, Jacob S Kazmi, Cyrus E Kuschner, Jun Hagiwara, Kanako Ito-Hagiwara, Eriko Nakamura, Lance B Becker, Kei Hayashida
Introduction: Mitochondrial transplantation (MTx) is an emerging strategy for restoring cellular bioenergetics and mitigating ischemia-reperfusion (IR) injury. We previously demonstrated that MTx improved neurological outcomes and survival in a rat model of cardiac arrest (CA). However, the mechanisms underlying these benefits, particularly regarding immune modulation and transcriptional regulation, remain unclear.
Methods: Adult C57BL/6 mice and Sprague-Dawley rats underwent CA and resuscitation protocols, followed by intravenous MTx with species-matched donor mitochondria. Survival and neurological outcomes were assessed up to 72 hours. Biodistribution and cellular uptake of fluorescent dye-labeled mitochondria were analyzed via in vivo imaging and flow cytometry. Gene expression related to mitochondrial dynamics, inflammation, and immune regulation was evaluated using qPCR.
Results: MTx improved 72-hour survival (33.3% vs. 0%, P=0.006) and neurological scores compared to vehicle treatment. Reduced brain edema was observed in MTx-treated animals. Mitochondrial uptake was significantly enhanced in the brain and spleen post-CA, with key infiltrating and resident immune cell populations-including monocytes, macrophages, microglia, astrocytes, and endothelial cells-preferentially internalizing transplanted mitochondria. Circulating myeloid cells rapidly internalized functional mitochondria, with 53.9% uptake in MTx-treated CA animals versus 10.6% in controls (P<0.001). MTx also modulated immune profiles, reducing pro-inflammatory macrophages and enhancing cytotoxic T cell numbers. Gene expression analysis showed that MTx downregulated Fission 1, preserved Mitofusin 2, and upregulated protective genes, including Hmox1, Sirt1, and Entpd1.
Conclusions: MTx improves outcomes after CA, accompanied by mitochondrial uptake by immune cells and redistribution to injured tissues. This process likely modulates immune responses, enhances mitochondrial fusion, and activates cytoprotective gene expression.
{"title":"Mitochondrial transplantation improves outcomes after cardiac arrest and resuscitation in mice.","authors":"Tomoaki Aoki, Yusuke Endo, Tai Yin, Jacob S Kazmi, Cyrus E Kuschner, Jun Hagiwara, Kanako Ito-Hagiwara, Eriko Nakamura, Lance B Becker, Kei Hayashida","doi":"10.1016/j.resuscitation.2025.110535","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110535","url":null,"abstract":"<p><strong>Introduction: </strong>Mitochondrial transplantation (MTx) is an emerging strategy for restoring cellular bioenergetics and mitigating ischemia-reperfusion (IR) injury. We previously demonstrated that MTx improved neurological outcomes and survival in a rat model of cardiac arrest (CA). However, the mechanisms underlying these benefits, particularly regarding immune modulation and transcriptional regulation, remain unclear.</p><p><strong>Methods: </strong>Adult C57BL/6 mice and Sprague-Dawley rats underwent CA and resuscitation protocols, followed by intravenous MTx with species-matched donor mitochondria. Survival and neurological outcomes were assessed up to 72 hours. Biodistribution and cellular uptake of fluorescent dye-labeled mitochondria were analyzed via in vivo imaging and flow cytometry. Gene expression related to mitochondrial dynamics, inflammation, and immune regulation was evaluated using qPCR.</p><p><strong>Results: </strong>MTx improved 72-hour survival (33.3% vs. 0%, P=0.006) and neurological scores compared to vehicle treatment. Reduced brain edema was observed in MTx-treated animals. Mitochondrial uptake was significantly enhanced in the brain and spleen post-CA, with key infiltrating and resident immune cell populations-including monocytes, macrophages, microglia, astrocytes, and endothelial cells-preferentially internalizing transplanted mitochondria. Circulating myeloid cells rapidly internalized functional mitochondria, with 53.9% uptake in MTx-treated CA animals versus 10.6% in controls (P<0.001). MTx also modulated immune profiles, reducing pro-inflammatory macrophages and enhancing cytotoxic T cell numbers. Gene expression analysis showed that MTx downregulated Fission 1, preserved Mitofusin 2, and upregulated protective genes, including Hmox1, Sirt1, and Entpd1.</p><p><strong>Conclusions: </strong>MTx improves outcomes after CA, accompanied by mitochondrial uptake by immune cells and redistribution to injured tissues. This process likely modulates immune responses, enhances mitochondrial fusion, and activates cytoprotective gene expression.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110535"},"PeriodicalIF":6.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-07DOI: 10.1016/j.resuscitation.2025.110531
Sigurd L Alnes, Florence M Aellen, Thomas Rusterholz, Andria Pelentritou, Matthias Hänggi, Andrea O Rossetti, Frédéric Zubler, Marzia De Lucia, Athina Tzovara
The capacity to integrate information across brain regions and sufficient diversity of neural activity is necessary for consciousness. In patients in a post-hypoxic ischemic coma, the integrity of the auditory processing network is indicative of chances of regaining consciousness. However, our understanding of how measures of integration and differentiation of auditory responses manifest across time of coma is limited. We investigated the temporal evolution of neural synchrony of auditory-evoked electroencephalographic (EEG) responses, measured via their phase-locking value (PLV), and of their neural complexity in unconscious post-hypoxic ischemic comatose patients. Our results show that the PLV was predictive of chances to regain consciousness within the first 40 hours post-cardiac arrest, while its predictive value diminished over subsequent time after coma onset. This was due to changing trajectories of PLV over time of coma for non-survivors, while survivors had stable PLV. The complexity of EEG responses was not different between patients who regained consciousness and those who did not, but it significantly diminished over time of coma, irrespective of the patient's outcome. Our findings provide novel insights on the optimal temporal window for assessing auditory functions in post-hypoxic ischemic coma. They are of particular importance for guiding the implementation of quantitative techniques for prognostication and contribute to an evolving understanding of neural functions within the acute comatose state.
{"title":"Temporal Dynamics of Neural Synchrony and Complexity of Auditory EEG Responses in Post-Hypoxic Ischemic Coma.","authors":"Sigurd L Alnes, Florence M Aellen, Thomas Rusterholz, Andria Pelentritou, Matthias Hänggi, Andrea O Rossetti, Frédéric Zubler, Marzia De Lucia, Athina Tzovara","doi":"10.1016/j.resuscitation.2025.110531","DOIUrl":"https://doi.org/10.1016/j.resuscitation.2025.110531","url":null,"abstract":"<p><p>The capacity to integrate information across brain regions and sufficient diversity of neural activity is necessary for consciousness. In patients in a post-hypoxic ischemic coma, the integrity of the auditory processing network is indicative of chances of regaining consciousness. However, our understanding of how measures of integration and differentiation of auditory responses manifest across time of coma is limited. We investigated the temporal evolution of neural synchrony of auditory-evoked electroencephalographic (EEG) responses, measured via their phase-locking value (PLV), and of their neural complexity in unconscious post-hypoxic ischemic comatose patients. Our results show that the PLV was predictive of chances to regain consciousness within the first 40 hours post-cardiac arrest, while its predictive value diminished over subsequent time after coma onset. This was due to changing trajectories of PLV over time of coma for non-survivors, while survivors had stable PLV. The complexity of EEG responses was not different between patients who regained consciousness and those who did not, but it significantly diminished over time of coma, irrespective of the patient's outcome. Our findings provide novel insights on the optimal temporal window for assessing auditory functions in post-hypoxic ischemic coma. They are of particular importance for guiding the implementation of quantitative techniques for prognostication and contribute to an evolving understanding of neural functions within the acute comatose state.</p>","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":" ","pages":"110531"},"PeriodicalIF":6.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-06DOI: 10.1016/j.resuscitation.2025.110532
Carsten Lott, Zoran Bahtijarević, Peter Klomp, Evert Verhagen, Jan Van Dooren, Federico Semeraro
{"title":"Increasing CPR awareness in Europe through EURO 2024: Lessons from “Get Trained Save Lives”","authors":"Carsten Lott, Zoran Bahtijarević, Peter Klomp, Evert Verhagen, Jan Van Dooren, Federico Semeraro","doi":"10.1016/j.resuscitation.2025.110532","DOIUrl":"10.1016/j.resuscitation.2025.110532","url":null,"abstract":"","PeriodicalId":21052,"journal":{"name":"Resuscitation","volume":"208 ","pages":"Article 110532"},"PeriodicalIF":6.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}