Este artículo analiza el potencial de la inteligencia artificial (IA) para transformar el sistema educativo de Panamá, con enfoque en la mejora del aprendizaje, la ampliación del acceso y la eficiencia administrativa. Desde un enfoque teórico basado en el marco del Banco Interamericano de Desarrollo, se examinan evidencias sobre intervenciones tecnológicas en América Latina y su aplicabilidad en contextos panameños, en especial en zonas rurales e indígenas. La metodología utilizada es cualitativa-documental, con revisión de literatura crítica y análisis temático. Los resultados indican que plataformas de retroalimentación automatizada, los sistemas predictivos de abandono escolar y tutores inteligentes pueden mejorar significativamente los resultados educativos, siempre que se acompañen de conectividad universal, formación docente contextualizada y gobernanza ética de datos. El análisis revela que, sin una política pública integral, la IA podría profundizar las brechas digitales. Se concluye que Panamá debe implementar un plan nacional de transformación digital en educación, estructurado en cuatro pilares: infraestructura equitativa, formación docente transformadora, herramientas contextualizadas y gobernanza ética. Se proponen acciones concretas, como pilotos en escuelas multigrado de comarcas indígenas y la creación de un sello de calidad ética para software educativo, para garantizar equidad, sostenibilidad y justicia algorítmica.
{"title":"Inteligencia artificial en la educación de Panamá: hacia una transformación digital con equidad y aprendizaje","authors":"Rodolfo Sanjur Maylín","doi":"10.38202/transforma01","DOIUrl":"https://doi.org/10.38202/transforma01","url":null,"abstract":"Este artículo analiza el potencial de la inteligencia artificial (IA) para transformar el sistema educativo de Panamá, con enfoque en la mejora del aprendizaje, la ampliación del acceso y la eficiencia administrativa. Desde un enfoque teórico basado en el marco del Banco Interamericano de Desarrollo, se examinan evidencias sobre intervenciones tecnológicas en América Latina y su aplicabilidad en contextos panameños, en especial en zonas rurales e indígenas. La metodología utilizada es cualitativa-documental, con revisión de literatura crítica y análisis temático. Los resultados indican que plataformas de retroalimentación automatizada, los sistemas predictivos de abandono escolar y tutores inteligentes pueden mejorar significativamente los resultados educativos, siempre que se acompañen de conectividad universal, formación docente contextualizada y gobernanza ética de datos. El análisis revela que, sin una política pública integral, la IA podría profundizar las brechas digitales. Se concluye que Panamá debe implementar un plan nacional de transformación digital en educación, estructurado en cuatro pilares: infraestructura equitativa, formación docente transformadora, herramientas contextualizadas y gobernanza ética. Se proponen acciones concretas, como pilotos en escuelas multigrado de comarcas indígenas y la creación de un sello de calidad ética para software educativo, para garantizar equidad, sostenibilidad y justicia algorítmica.","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":"1 1","pages":"7-15"},"PeriodicalIF":0.0,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://doi.org/10.38202/transforma01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder that impairs motor functions, affects 1 in 50,000 people in the world, and has an insignificant hereditary component, with 90% of patients sans any family history of the disease. ALS is a debilitating disease due to the limited effectiveness of treatments. TARDBP, the gene of interest, encodes The TransActive Response DNA-binding protein 43 (TDP-43 (kDa)). Mutations in this gene result in TDP-43 that may undergo deregulated expression (gain or loss of function), be misfolded, cleaved, aggregated, and/or mislocalized. More specifically, TDP-43 may also be aberrantly ubiquitinated, phosphorylated, cleaved, or nuclear depleted. The resultant proteinopathy is associated in the causal chain of many neurodegenerative disorders, including in > 95% of patients with sporadic ALS. TDP-43 consists of mitochondrial and nuclear localization sequences; RNA recognition motifs; intrinsically disordered regions and is involved in the appropriate splicing and transcription of a host of protein-coding-genes. Preventing and/or correcting dysregulated TDP-43 homeostasis and proteinopathy is near-universally effective in vitro and in animal models. This study focuses on analyzing the benefits and limitations of the therapeutic strategies used to treat ALS caused by dysregulated TDP-43 homeostasis and identifying promising methods to target this proteinopathy.
{"title":"Analysis of the therapeutic strategies used to treat Amyotrophic Lateral Sclerosis caused by TDP-43 aggregation and/or mislocalization","authors":"Sonya Sar","doi":"10.64336/001c.122193","DOIUrl":"https://doi.org/10.64336/001c.122193","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS), a fatal neurodegenerative disorder that impairs motor functions, affects 1 in 50,000 people in the world, and has an insignificant hereditary component, with 90% of patients sans any family history of the disease. ALS is a debilitating disease due to the limited effectiveness of treatments. TARDBP, the gene of interest, encodes The TransActive Response DNA-binding protein 43 (TDP-43 (kDa)). Mutations in this gene result in TDP-43 that may undergo deregulated expression (gain or loss of function), be misfolded, cleaved, aggregated, and/or mislocalized. More specifically, TDP-43 may also be aberrantly ubiquitinated, phosphorylated, cleaved, or nuclear depleted. The resultant proteinopathy is associated in the causal chain of many neurodegenerative disorders, including in > 95% of patients with sporadic ALS. TDP-43 consists of mitochondrial and nuclear localization sequences; RNA recognition motifs; intrinsically disordered regions and is involved in the appropriate splicing and transcription of a host of protein-coding-genes. Preventing and/or correcting dysregulated TDP-43 homeostasis and proteinopathy is near-universally effective in vitro and in animal models. This study focuses on analyzing the benefits and limitations of the therapeutic strategies used to treat ALS caused by dysregulated TDP-43 homeostasis and identifying promising methods to target this proteinopathy.","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jhss.scholasticahq.com/article/122193.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147882951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-01DOI: 10.4131/jshpreview.31.129
Kazutaka Yamamoto
{"title":"Foreword","authors":"Kazutaka Yamamoto","doi":"10.4131/jshpreview.31.129","DOIUrl":"https://doi.org/10.4131/jshpreview.31.129","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46891639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.114
Kenji Ohta
{"title":"ダイヤモンドアンビルセル中の物質の高温高圧その場熱物性測定","authors":"Kenji Ohta","doi":"10.4131/jshpreview.32.114","DOIUrl":"https://doi.org/10.4131/jshpreview.32.114","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44900587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.138
Masaki Mito
{"title":"超伝導量子干渉素子を用いた高圧力下磁気測定","authors":"Masaki Mito","doi":"10.4131/jshpreview.32.138","DOIUrl":"https://doi.org/10.4131/jshpreview.32.138","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45450970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.129
R. Matsumoto, Sayaka Yamamoto, Y. Takano
{"title":"High-Pressure Synthesis and In-Situ Physical Property Measurement Using Boron-Doped Diamond","authors":"R. Matsumoto, Sayaka Yamamoto, Y. Takano","doi":"10.4131/jshpreview.32.129","DOIUrl":"https://doi.org/10.4131/jshpreview.32.129","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45157552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.120
K. Kitagawa, Naoka Hiraoka, Y. Arai, H. Takagi
{"title":"Magnetization and NMR Measurements Using Opposed-Type Anvil Cells on Quantum Magnetism and Superconductivity","authors":"K. Kitagawa, Naoka Hiraoka, Y. Arai, H. Takagi","doi":"10.4131/jshpreview.32.120","DOIUrl":"https://doi.org/10.4131/jshpreview.32.120","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47131977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.159
T. Hattori
{"title":"第10回アジア高圧会議(10th Asian Conference on High Pressure Research) 報告","authors":"T. Hattori","doi":"10.4131/jshpreview.32.159","DOIUrl":"https://doi.org/10.4131/jshpreview.32.159","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47252184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.157
Riki Kobayashi
{"title":"琉球大学 理学部 物質地球科学科物理系 多重自由度相関研究室（物性物理学）","authors":"Riki Kobayashi","doi":"10.4131/jshpreview.32.157","DOIUrl":"https://doi.org/10.4131/jshpreview.32.157","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42230950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-01DOI: 10.4131/jshpreview.32.111
Fumiyoshi Abe
{"title":"高圧バイオサイエンスという異分野交流","authors":"Fumiyoshi Abe","doi":"10.4131/jshpreview.32.111","DOIUrl":"https://doi.org/10.4131/jshpreview.32.111","url":null,"abstract":"","PeriodicalId":39932,"journal":{"name":"Review of High Pressure Science and Technology/Koatsuryoku No Kagaku To Gijutsu","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45160634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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