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Use of Extracorporeal Membrane Oxygenation for Management of Hemostasis After Complex Cardiac Surgery 体外膜氧合在复杂心脏手术后止血中的应用
Pub Date : 2026-09-01 Epub Date: 2026-04-01 DOI: 10.1016/j.atssr.2026.03.013
Dagmawi Demessie MD, Yara Menassa MD, Aabha Divya MD, Jamil Borgi MD
Intractable bleeding during cardiac surgery is a rare but life-threatening complication. We describe a novel management approach in which the patient was supported with venoarterial extracorporeal membrane oxygenation until hemostasis could be achieved. This approach serves as an unloading technique for the heart while allowing compression of bleeding sites and safe transfusion without hemodynamic instability or myocardial dysfunction.
Intractable bleeding during cardiac surgery is a rare but life-threatening complication. We describe a novel management approach in which the patient was supported with venoarterial extracorporeal membrane oxygenation until hemostasis could be achieved. This approach serves as an unloading technique for the heart while allowing compression of bleeding sites and safe transfusion without hemodynamic instability or myocardial dysfunction.
心脏手术中难治性出血是一种罕见但危及生命的并发症。我们描述了一种新的管理方法,其中患者支持静脉动脉体外膜氧合,直到止血可以实现。这种方法可以作为心脏的卸载技术,同时可以压缩出血部位和安全输血,而不会出现血流动力学不稳定或心肌功能障碍。心脏手术中难治性出血是一种罕见但危及生命的并发症。我们描述了一种新的管理方法,其中患者支持静脉动脉体外膜氧合,直到止血可以实现。这种方法可以作为心脏的卸载技术,同时可以压缩出血部位和安全输血,而不会出现血流动力学不稳定或心肌功能障碍。
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引用次数: 0
Posterior Pericardiotomy: Historical Perspective, Current Techniques, and Clinical Outcomes 后心包切开术:历史观点、当前技术和临床结果
Pub Date : 2026-09-01 Epub Date: 2026-03-26 DOI: 10.1016/j.atssr.2026.03.006
Edward Hauptmann MD, Erin Hoover MD, Raghav Chandra MD, Madhuri Nagaraj MD, Paige Deblieux MD, Jasmina Ehab MD, Suresh Keshavamurthy MD

Background

Cardiac tamponade and postoperative atrial fibrillation remain significant challenges after cardiac surgery, contributing to higher morbidity, mortality, and health care costs. Posterior pericardiotomy (PP) has been used to reduce these complications. This review summarizes the history, technique, and clinical evidence for PP.

Methods

We identified recent studies related to PP to perform a narrative overview of its indications, techniques, and clinical outcomes. This was supplemented with historical context from cardiac surgeons who were early adopters of the procedure.

Results

Evidence demonstrates that PP reduces postoperative pericardial effusion, tamponade, and postoperative atrial fibrillation by improving pericardial drainage, preventing tamponade, and secondarily decreasing pericardial inflammation and oxidative stress.

Conclusions

Despite receiving a class 2a recommendation in recent American College of Cardiology guidelines for atrial fibrillation prevention, PP is not widely performed. Given its simplicity, safety, and effectiveness, wider use of PP could improve outcomes after cardiac surgery.
心脏填塞和术后心房颤动仍然是心脏手术后的重大挑战,导致更高的发病率、死亡率和医疗费用。后路心包切开术(PP)已被用于减少这些并发症。这篇综述总结了PP的历史、技术和临床证据。方法我们收集了最近与PP相关的研究,对其适应症、技术和临床结果进行了叙述概述。这与早期采用该手术的心脏外科医生的历史背景相辅相成。结果PP可通过改善心包引流、预防心包填塞、降低心包炎症和氧化应激,减少术后心包积液、心包填塞和术后房颤的发生。结论:尽管在最近的美国心脏病学会房颤预防指南中获得2a级推荐,但PP并未广泛应用。由于其简单、安全、有效,广泛使用PP可以改善心脏手术后的预后。
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引用次数: 0
Sinus of Valsalva Involvement Affects Aortic Root Growth After Acute Type A Aortic Dissection Repair 主动脉窦受累影响急性A型主动脉夹层修复后主动脉根部生长
Pub Date : 2026-09-01 Epub Date: 2026-03-18 DOI: 10.1016/j.atssr.2026.02.035
Ting-Wei Lin MD, MS, Wei-Lin Hsu MD, Heng Su MD, Yi-Chen Wang MD, Hsuan-Yin Wu MD
<div><h3>Background</h3><div>Root-preserving repair is commonly used for acute type A aortic dissection without root aneurysm or sinus tears. We evaluated whether the extent of sinus of Valsalva involvement predicts late outcomes and postoperative aortic root growth.</div></div><div>Root-preserving repair is commonly used for acute type A aortic dissection without root aneurysm or sinus tears. We evaluated whether the extent of sinus of Valsalva involvement predicts late outcomes and postoperative aortic root growth.</div><div><h3>Methods</h3><div>We conducted a single-center retrospective study of patients undergoing root-preserving acute type A aortic dissection repair with >1 month follow-up and ≥1 postoperative imaging. Fifty patients were included and stratified by sinus of Valsalva involvement (≥2 vs <2 sinus involvement). Primary outcomes were aortic root adverse event–free survival and longitudinal root diameter.</div></div><div>We conducted a single-center retrospective study of patients undergoing root-preserving acute type A aortic dissection repair with >1 month follow-up and ≥1 postoperative imaging. Fifty patients were included and stratified by sinus of Valsalva involvement (≥2 vs <2 sinus involvement). Primary outcomes were aortic root adverse event–free survival and longitudinal root diameter.</div><div><h3>Results</h3><div>Baseline and perioperative characteristics were similar between groups, and no late aorta-related deaths occurred. Aortic root adverse event–free survival was worse with ≥2 sinuses than with <2 (<em>P</em> = .027). At 10 years, the ≥2 sinus involvement group had an estimated mean aortic root diameter of 50.38 mm vs 40.18 mm in the <2 group. The mean root diameter was 10.19 mm larger (95% CI, 4.27-16.11; <em>P</em> = .001) in the ≥2 sinus involvement group at 10 years.</div></div><div>Baseline and perioperative characteristics were similar between groups, and no late aorta-related deaths occurred. Aortic root adverse event–free survival was worse with ≥2 sinuses than with <2 (<em>P</em> = .027). At 10 years, the ≥2 sinus involvement group had an estimated mean aortic root diameter of 50.38 mm vs 40.18 mm in the <2 group. The mean root diameter was 10.19 mm larger (95% CI, 4.27-16.11; <em>P</em> = .001) in the ≥2 sinus involvement group at 10 years.</div><div><h3>Conclusions</h3><div>The degree of sinus of Valsalva involvement is associated with postoperative aortic root enlargement and adverse root events after root-preserving repair. In experienced centers, broader use of aortic root replacement, preferably valve-sparing procedures, may be considered for patients with involvement of ≥2 sinuses.</div></div><div>The degree of sinus of Valsalva involvement is associated with postoperative aortic root enlargement and adverse root events after root-preserving repair. In experienced centers, broader use of aortic root replacement, preferably valve-sparing procedures, may be considered for pat
背景:保留根部修复术常用于急性A型主动脉夹层,无根部动脉瘤或窦性撕裂。我们评估了Valsalva窦受累程度是否能预测晚期预后和术后主动脉根生长。保根修复常用于急性A型主动脉夹层,无根动脉瘤或窦性撕裂。我们评估了Valsalva窦受累程度是否能预测晚期预后和术后主动脉根生长。方法对急性a型主动脉夹层保根修复术患者进行单中心回顾性研究,随访1个月,术后影像学检查≥1次。50例患者被纳入并按受累的Valsalva窦(≥2 vs <2)进行分层。主要结局是主动脉根部无不良事件生存和纵向根部直径。我们对接受保根急性a型主动脉夹层修复术的患者进行了一项单中心回顾性研究,随访1个月,术后影像学检查≥1次。50例患者被纳入并按受累的Valsalva窦(≥2 vs <2)进行分层。主要结局是主动脉根部无不良事件生存和纵向根部直径。结果两组患者的基线和围手术期特征相似,未发生晚期主动脉相关死亡。≥2个鼻窦组的主动脉根部无不良事件生存率低于≥2个鼻窦组(P = 0.027)。10年时,≥2个窦受累组估计主动脉根平均直径为50.38 mm,而≥2个窦受累组为40.18 mm。10年时,≥2个鼻窦受累组的平均根径增大10.19 mm (95% CI, 4.27-16.11; P = .001)。两组之间的基线和围手术期特征相似,未发生晚期主动脉相关死亡。≥2个鼻窦组的主动脉根部无不良事件生存率低于≥2个鼻窦组(P = 0.027)。10年时,≥2个窦受累组估计主动脉根平均直径为50.38 mm,而≥2个窦受累组为40.18 mm。10年时,≥2个鼻窦受累组的平均根径增大10.19 mm (95% CI, 4.27-16.11; P = .001)。结论主动脉瓣窦受累程度与术后主动脉根扩大及保留根修复后的不良根事件有关。在经验丰富的中心,对于累及≥2个鼻窦的患者,可以考虑更广泛地使用主动脉根置换术,最好是保留瓣膜的手术。Valsalva窦受累程度与术后主动脉根扩大和保留根修复后的不良根事件有关。在经验丰富的中心,对于累及≥2个鼻窦的患者,可以考虑更广泛地使用主动脉根置换术,最好是保留瓣膜的手术。下载:下载高清图片(272KB)下载:下载全尺寸图片
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引用次数: 0
Contained Rupture of the Ascending Aorta Caused by Primary Aldosteronism 原发性醛固酮增多症引起的隐伏性升主动脉破裂
Pub Date : 2026-09-01 Epub Date: 2026-03-18 DOI: 10.1016/j.atssr.2026.02.032
Étienne Fasolt Richard Corvin Meinert MD, Arlene Körner MD, Willem Hendrik te Gussinklo MD, Alexander Brobeil MD, Matthias Karck MD, Bashar Dib MD
A 36-year-old female patient presented with syncope and retrosternal chest pain. Computed tomography revealed contained rupture of the ascending aorta with no false lumen but an intraluminal thrombus. She underwent emergent open aortic repair. Postoperatively, refractory hypertension was noticeable. Upon further examination of the computed tomographic scan, a large right-sided adrenal mass became evident. Endocrinologic workup ruled out pheochromocytoma and revealed primary aldosteronism. She underwent robotic adrenalectomy, subsequently showed close to normal blood pressure values, and was discharged without further complications. We present here a rare case of contained aortic rupture in the setting of primary aldosteronism.
A 36-year-old female patient presented with syncope and retrosternal chest pain. Computed tomography revealed contained rupture of the ascending aorta with no false lumen but an intraluminal thrombus. She underwent emergent open aortic repair. Postoperatively, refractory hypertension was noticeable. Upon further examination of the computed tomographic scan, a large right-sided adrenal mass became evident. Endocrinologic workup ruled out pheochromocytoma and revealed primary aldosteronism. She underwent robotic adrenalectomy, subsequently showed close to normal blood pressure values, and was discharged without further complications. We present here a rare case of contained aortic rupture in the setting of primary aldosteronism.
一名36岁女性患者表现为晕厥和胸骨后胸痛。计算机断层扫描显示升主动脉破裂,无假腔,但腔内血栓。她接受了紧急主动脉切开修复术。术后发现难治性高血压。在进一步的计算机断层扫描检查中,发现一大块右侧肾上腺肿块。内分泌检查排除嗜铬细胞瘤,显示原发性醛固酮增多症。她接受了机器人肾上腺切除术,随后显示血压接近正常,并出院,没有进一步的并发症。我们在此报告一例罕见的原发性醛固酮增多症患者的主动脉破裂。一名36岁女性患者表现为晕厥和胸骨后胸痛。计算机断层扫描显示升主动脉破裂,无假腔,但腔内血栓。她接受了紧急主动脉切开修复术。术后发现难治性高血压。在进一步的计算机断层扫描检查中,发现一大块右侧肾上腺肿块。内分泌检查排除嗜铬细胞瘤,显示原发性醛固酮增多症。她接受了机器人肾上腺切除术,随后显示血压接近正常,并出院,没有进一步的并发症。我们在此报告一例罕见的原发性醛固酮增多症患者的主动脉破裂。
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引用次数: 0
Impact of Systemic Pulmonary Shunt for Tetralogy of Fallot on Pulmonary Valve Annulus Growth and Midterm Pulmonary Valve Function 法洛四联症全身性肺分流对肺瓣膜环生长和中期肺瓣膜功能的影响
Pub Date : 2026-09-01 Epub Date: 2026-03-10 DOI: 10.1016/j.atssr.2026.02.025
Tsutomu Hataoka MD, Fumiaki Shikata MD, PhD, Toru Okamura MD, PhD, Norihiko Oka MD, PhD, Takahiro Tomoyasu MD, PhD, Masahiro Kaneko MD, PhD, Yoshikiyo Matsunaga MD, Kenta Matsui MD, Sakura Horie MD, Kagami Miyaji MD, PhD

Background

Tetralogy of Fallot (TOF) often requires transannular patch repair, leading to pulmonary regurgitation. Systemic pulmonary shunt can be associated with pulmonary valve annulus (PVA) growth, thus potentially enabling valve-sparing repair. This study evaluated PVA growth after systemic pulmonary shunt and the midterm impact of valve-sparing repair on pulmonary valve function.

Methods

We reviewed 54 patients with TOF who underwent staged repair with systemic pulmonary shunt. PVA z scores were compared before and after systemic pulmonary shunt. Freedom from pulmonary regurgitation (PR) was assessed. Freedom from PR was defined as PR less than moderate.

Results

The median follow-up duration after intracardiac repair was 7.6 years (interquartile range [IQR], 3.1-10.8 years). In the staged repair group, the median PVA z score increased from −3.4 (IQR, −5.2 to −2.6) at the time of systemic pulmonary shunt to −2.7 (IQR, −4.4 to −1.8) before intracardiac repair. Freedom from PR at 8 years after intracardiac repair was higher in the valve-sparing repair group (84% vs 45%; P = .009). The pre–systemic pulmonary shunt PVA z score was a significant predictor of PVA growth (odds ratio, 1.87; P = .002), with a threshold of −4.1 predicting growth with 82.1% sensitivity and 72.7% specificity.

Conclusions

PVA growth was observed in patients with TOF after systemic pulmonary shunt. The pre–systemic pulmonary shunt PVA z score predicts successful growth and informs surgical planning. Valve-sparing repair offers superior midterm freedom from PR compared with transannular patch repair.
法洛四联症(TOF)通常需要经环补片修复,导致肺反流。系统性肺分流可能与肺动脉瓣环(PVA)的生长有关,因此可能导致保留瓣膜的修复。本研究评估了全体性肺分流术后PVA的生长情况以及保留瓣膜修复对肺瓣膜功能的中期影响。方法回顾性分析54例TOF患者行系统性肺分流分阶段修复术。比较全身性肺分流术前后PVA z评分。评估肺返流自由(PR)。免于公关的自由被定义为公关少于适度。结果心脏内修复术后中位随访时间为7.6年(四分位间距为3.1 ~ 10.8年)。在分阶段修复组中,PVA z评分中位数从全身性肺分流时的- 3.4 (IQR, - 5.2至- 2.6)增加到心内修复前的- 2.7 (IQR, - 4.4至- 1.8)。保留瓣膜修复组在心脏内修复后8年的PR自由度更高(84% vs 45%; P = 0.009)。系统性肺分流前PVA z评分是PVA生长的重要预测因子(优势比为1.87;P = 0.002),预测PVA生长的阈值为- 4.1,敏感性为82.1%,特异性为72.7%。结论TOF患者行全身肺分流术后可观察到spva的生长。全身前肺分流PVA z评分预测生长成功,并指导手术计划。与经环补片修复相比,保留瓣膜的修复提供了更好的中期PR自由。
{"title":"Impact of Systemic Pulmonary Shunt for Tetralogy of Fallot on Pulmonary Valve Annulus Growth and Midterm Pulmonary Valve Function","authors":"Tsutomu Hataoka MD,&nbsp;Fumiaki Shikata MD, PhD,&nbsp;Toru Okamura MD, PhD,&nbsp;Norihiko Oka MD, PhD,&nbsp;Takahiro Tomoyasu MD, PhD,&nbsp;Masahiro Kaneko MD, PhD,&nbsp;Yoshikiyo Matsunaga MD,&nbsp;Kenta Matsui MD,&nbsp;Sakura Horie MD,&nbsp;Kagami Miyaji MD, PhD","doi":"10.1016/j.atssr.2026.02.025","DOIUrl":"10.1016/j.atssr.2026.02.025","url":null,"abstract":"<div><h3>Background</h3><div>Tetralogy of Fallot (TOF) often requires transannular patch repair, leading to pulmonary regurgitation. Systemic pulmonary shunt can be associated with pulmonary valve annulus (PVA) growth, thus potentially enabling valve-sparing repair. This study evaluated PVA growth after systemic pulmonary shunt and the midterm impact of valve-sparing repair on pulmonary valve function.</div></div><div><h3>Methods</h3><div>We reviewed 54 patients with TOF who underwent staged repair with systemic pulmonary shunt. PVA <em>z</em> scores were compared before and after systemic pulmonary shunt. Freedom from pulmonary regurgitation (PR) was assessed. Freedom from PR was defined as PR less than moderate.</div></div><div><h3>Results</h3><div>The median follow-up duration after intracardiac repair was 7.6 years (interquartile range [IQR], 3.1-10.8 years). In the staged repair group, the median PVA <em>z</em> score increased from −3.4 (IQR, −5.2 to −2.6) at the time of systemic pulmonary shunt to −2.7 (IQR, −4.4 to −1.8) before intracardiac repair. Freedom from PR at 8 years after intracardiac repair was higher in the valve-sparing repair group (84% vs 45%; <em>P</em> = .009). The pre–systemic pulmonary shunt PVA <em>z</em> score was a significant predictor of PVA growth (odds ratio, 1.87; <em>P</em> = .002), with a threshold of −4.1 predicting growth with 82.1% sensitivity and 72.7% specificity.</div></div><div><h3>Conclusions</h3><div>PVA growth was observed in patients with TOF after systemic pulmonary shunt. The pre–systemic pulmonary shunt PVA <em>z</em> score predicts successful growth and informs surgical planning. Valve-sparing repair offers superior midterm freedom from PR compared with transannular patch repair.</div></div>","PeriodicalId":72234,"journal":{"name":"Annals of thoracic surgery short reports","volume":"4 3","pages":"Pages 857-862"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148870938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Biological Reaction to a Synthetic Hybrid Patch Inducing Tissue Ingrowth as a Senning Atrial Baffle 诱导组织长入的合成杂化贴片作为感应心房挡板的早期生物学反应
Pub Date : 2026-09-01 Epub Date: 2026-03-11 DOI: 10.1016/j.atssr.2026.02.030
Akira Yamaguchi MD, Hiroomi Murayama MD, Shintaro Nemoto MD, PhD
We report a case in which a new synthetic hybrid patch inducing autologous tissue ingrowth was used to replace the obstructed Senning atrial baffle in a double switch operation for congenitally corrected transposition of the great arteries. However, recurrent baffle obstruction developed after 10 months postoperatively and was removed. Histology of the excised specimen showed promising tissue ingrowth but cautionary peripheral folding of the patch in this clinically challenging condition.
We report a case in which a new synthetic hybrid patch inducing autologous tissue ingrowth was used to replace the obstructed Senning atrial baffle in a double switch operation for congenitally corrected transposition of the great arteries. However, recurrent baffle obstruction developed after 10 months postoperatively and was removed. Histology of the excised specimen showed promising tissue ingrowth but cautionary peripheral folding of the patch in this clinically challenging condition.
我们报告了一例在先天性大动脉转位的双开关手术中,使用一种新的合成杂交贴片诱导自体组织向内生长来取代阻塞的Senning心房挡板。然而,术后10个月后复发的挡板梗阻被切除。切除标本的组织学显示有希望的组织长入,但在这种具有临床挑战性的情况下,斑块的周围折叠是警告性的。我们报告了一例在先天性大动脉转位的双开关手术中,使用一种新的合成杂交贴片诱导自体组织向内生长来取代阻塞的Senning心房挡板。然而,术后10个月后复发的挡板梗阻被切除。切除标本的组织学显示有希望的组织长入,但在这种具有临床挑战性的情况下,斑块的周围折叠是警告性的。
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引用次数: 0
Tidal Volume Discrepancy for Air Leak Detection in Thoracoscopic Lung Resection in Smokers 在吸烟者胸腔镜肺切除术中检测漏气的潮气量差异
Pub Date : 2026-09-01 Epub Date: 2026-03-11 DOI: 10.1016/j.atssr.2026.02.028
Masaya Otabe MD, Masayuki Ishida MD, Atsushi Kamigaichi MD, Atsushi Kagimoto MD, PhD, Michiyoshi Sanuki MD, PhD, Takeshi Mimura MD, PhD

Background

Prolonged air leakage (PAL) is a common postoperative complication after lung resection. The conventional air leak test, widely used to detect intraoperative air leaks, is limited to restricted thoracic space during lung inflation, which may result in undetected leaks, and fragile lung parenchyma may allow new air leaks to develop during chest closure. This study evaluated the efficacy of tidal volume discrepancy monitoring for intraoperative air leak detection during video-assisted thoracoscopic surgery anatomical lung resection (lobectomy and segmentectomy).

Methods

We retrospectively reviewed 310 patients with a smoking history who underwent video-assisted thoracoscopic surgery anatomical lung resection for non-small cell lung cancer. Since May 2020, a new intraoperative air leak assessment method was implemented. After the conventional air leak test, bilateral lung ventilation was continued until chest closure, with continuous monitoring of inspired and expired tidal volumes. A sustained discrepancy >20 mL per breath prompted further intrathoracic inspection and repair.

Results

PAL occurred in 4.1% of patients in the new method group, significantly lower than 10.9% in the conventional method group (P = .0205). Multivariate analysis identified the evaluation method and presence of intrathoracic adhesion as independent predictors of PAL. Importantly, all procedures were completed thoracoscopically, including a substantial number of segmentectomies.

Conclusions

Intraoperative evaluation of intraoperative air leaks using tidal volume discrepancies is a reliable and effective method to detect air leaks and reduce PAL incidence in video-assisted thoracoscopic surgery anatomical lung resections.
背景长时间漏气(PAL)是肺切除术后常见的并发症。传统的漏气试验广泛用于术中漏气的检测,但由于肺膨胀时胸腔空间受限,可能导致漏气未被发现,而肺实质脆弱,可能使闭合胸时产生新的漏气。本研究评估了潮气量差监测在视频胸腔镜解剖肺切除术(肺叶切除术和肺节段切除术)术中检测漏气的效果。方法回顾性分析310例有吸烟史的胸腔镜下非小细胞肺癌解剖切除术患者。自2020年5月起,实施了新的术中空气泄漏评估方法。常规漏气试验结束后,继续双侧肺通气至闭胸,持续监测吸气和呼气潮气量。每次呼吸持续20毫升的差异促使进一步进行胸内检查和修复。结果新方法组spal发生率为4.1%,显著低于常规方法组的10.9% (P = 0.0205)。多变量分析确定评估方法和胸内粘连的存在是PAL的独立预测因素。重要的是,所有手术都是在胸腔镜下完成的,包括大量的节段切除术。结论术中应用潮气量差评价术中漏气是一种可靠、有效的方法,可在胸腔镜解剖肺切除术中发现漏气,减少PAL的发生。
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引用次数: 0
Simultaneous Robotic Off-Pump Coronary Artery Bypass and Orthotopic Liver Transplantation in a Child-Pugh C Patient: An Operative Playbook 机器人非体外循环冠状动脉搭桥术和原位肝移植在Child-Pugh C患者中的应用:手术指南
Pub Date : 2026-09-01 Epub Date: 2026-03-03 DOI: 10.1016/j.atssr.2026.02.017
Leonardo Paim N da Costa MD, PhD, Nicholas Prinz BA, Diego Reino MD, Vijay Subramanian MD, Kiran Dhanireddy MD, Lucian Lozonschi MD
A 69-year-old male individual with Child-Pugh class C alcoholic cirrhosis and 2-vessel coronary artery disease underwent combined robotic off-pump minimally invasive direct coronary artery bypass (MIDCAB) and simultaneous orthotopic liver transplant. The patient tolerated the procedure without complications, was extubated on postoperative day 1, and discharged home on day 9. At 15 months postprocedure he had preserved graft function, stable liver tests, and no major adverse cardiac events. This novel procedure of combined robotic minimally invasive direct coronary artery bypass and orthotopic liver transplant may offer a promising alternative for high-risk patients with end-stage liver disease and coronary artery disease.
A 69-year-old male individual with Child-Pugh class C alcoholic cirrhosis and 2-vessel coronary artery disease underwent combined robotic off-pump minimally invasive direct coronary artery bypass (MIDCAB) and simultaneous orthotopic liver transplant. The patient tolerated the procedure without complications, was extubated on postoperative day 1, and discharged home on day 9. At 15 months postprocedure he had preserved graft function, stable liver tests, and no major adverse cardiac events. This novel procedure of combined robotic minimally invasive direct coronary artery bypass and orthotopic liver transplant may offer a promising alternative for high-risk patients with end-stage liver disease and coronary artery disease.
一例69岁男性Child-Pugh C级酒精性肝硬化合并2支冠状动脉疾病患者接受了机器人体外微创直接冠状动脉搭桥术(MIDCAB)和原位肝移植联合治疗。患者耐受手术,无并发症,术后第1天拔管,第9天出院。术后15个月,患者移植物功能保持,肝脏检查稳定,无重大心脏不良事件。这种新型的机器人微创直接冠状动脉搭桥和原位肝移植联合手术可能为终末期肝脏疾病和冠状动脉疾病的高危患者提供一个有希望的选择。一例69岁男性Child-Pugh C级酒精性肝硬化合并2支冠状动脉疾病患者接受了机器人体外微创直接冠状动脉搭桥术(MIDCAB)和原位肝移植联合治疗。患者耐受手术,无并发症,术后第1天拔管,第9天出院。术后15个月,患者移植物功能保持,肝脏检查稳定,无重大心脏不良事件。这种新型的机器人微创直接冠状动脉搭桥和原位肝移植联合手术可能为终末期肝脏疾病和冠状动脉疾病的高危患者提供一个有希望的选择。
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引用次数: 0
Application of Bilateral Sympathetic Nerve Cryoablation as a Bridge to Transplant for Refractory Ventricular Tachycardia 双侧交感神经冷冻消融术在难治性室性心动过速移植中的应用
Pub Date : 2026-09-01 Epub Date: 2026-02-20 DOI: 10.1016/j.atssr.2026.02.005
Marilina La Porta MD, Mathieu Echivard MD, Stéphane Renaud MD, PhD, Joseph Seitlinger MD, PhD
This case report describes a medically fragile patient with sustained ventricular arrhythmia who was anticoagulated and thus underwent bilateral video-assisted thoracoscopic sympathetic cryoablation as the least-invasive option. This technique provides a temporary, reversible sympathetic block, reducing procedural risks compared with conventional denervation. The gradual inverse nerve remodeling after cryoablation may account for early arrhythmic recurrences. Overall, this approach shows promise for rhythm control and safety in high-risk patients, but further evaluation is required.
This case report describes a medically fragile patient with sustained ventricular arrhythmia who was anticoagulated and thus underwent bilateral video-assisted thoracoscopic sympathetic cryoablation as the least-invasive option. This technique provides a temporary, reversible sympathetic block, reducing procedural risks compared with conventional denervation. The gradual inverse nerve remodeling after cryoablation may account for early arrhythmic recurrences. Overall, this approach shows promise for rhythm control and safety in high-risk patients, but further evaluation is required.
本病例报告描述了一位身体虚弱的持续性室性心律失常患者,他进行了抗凝治疗,因此接受了双侧胸腔镜交感神经冷冻消融术作为最小创伤的选择。该技术提供了一个暂时的、可逆的交感神经阻滞,与传统的去神经控制相比,减少了手术风险。冷冻消融后逐渐的神经逆重构可能是早期心律失常复发的原因。总的来说,这种方法在高危患者的心律控制和安全性方面显示出希望,但需要进一步的评估。本病例报告描述了一位身体虚弱的持续性室性心律失常患者,他进行了抗凝治疗,因此接受了双侧胸腔镜交感神经冷冻消融术作为最小创伤的选择。该技术提供了一个暂时的、可逆的交感神经阻滞,与传统的去神经控制相比,减少了手术风险。冷冻消融后逐渐的神经逆重构可能是早期心律失常复发的原因。总的来说,这种方法在高危患者的心律控制和安全性方面显示出希望,但需要进一步的评估。
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引用次数: 0
The Impact of Preexisting Diabetes Mellitus on Chronic Lung Allograft Dysfunction After Lung Transplantation 既往糖尿病对肺移植术后慢性同种异体肺功能障碍的影响
Pub Date : 2026-09-01 Epub Date: 2026-03-11 DOI: 10.1016/j.atssr.2026.02.029
Ye In Christopher Kwon BA, Michael Keller BS, Holly Caboti-Jones BS, Matthew Ambrosio MS, Barry C. Gibney DO, Luca Paoletti MD, Rachit D. Shah MD, Vipul Patel MD, Vigneshwar Kasirajan MD, Zubair A. Hashmi MD

Background

Chronic lung allograft dysfunction (CLAD) remains a major cause of mortality after lung transplantation. Diabetes mellitus (DM) may contribute to CLAD through metabolic dysregulation. We evaluated post–lung transplant outcomes in recipients with DM.

Methods

Adults undergoing first-time, isolated lung transplant (November 2017 to December 2024) with at least 6 months of follow-up were identified in the United Network for Organ Sharing registry and stratified by DM diagnosis at waitlist registration. CLAD was defined as ≥20% forced expiratory volume in 1 second and/or forced vital capacity decline after >3 months follow-up. Kaplan-Meier and multivariable Cox models assessed survival and CLAD risk, with subgroup analysis by race and ethnicity.

Results

Among 18,199 analyzed patients, 3479 (18.3%) had DM. CLAD rates were higher among recipients with DM (21.3% vs 17.4%, P = .003). Grade 3 primary graft dysfunction at 72 hours was more frequent among recipients with DM (20.3% vs 17.1%, P = .03). Additionally, 5-year overall survival was lower in DM patients (55.2% vs 58.7%, P = .003). On multivariate analysis, DM was associated with increased risk of 5-year mortality (hazard ratio, 2.58, P = .004) and CLAD (odds ratio, 1.46, P = .03). Notably, in patients with DM, 5-year survival was significantly decreased among Asian patients (P = .024) compared with other races. Among patients with DM, Asian status was independently associated with increased risk of mortality (hazard ratio, 1.72, P = .002).

Conclusions

Recipient DM is associated with reduced long-term survival and CLAD risk after lung transplant. Asian American recipients with DM appear to face disproportionately worse survival, suggesting a potential interaction between race, ethnicity, and metabolic status.
慢性同种异体肺移植功能障碍(chronic lung allograft dysfunction, CLAD)仍然是肺移植术后死亡的主要原因。糖尿病(DM)可能通过代谢失调导致CLAD。我们评估了DM受体肺移植后的结果。方法:在联合器官共享注册网络中确定首次进行分离肺移植的成人(2017年11月至2024年12月),随访至少6个月,并在等待名单注册时根据DM诊断进行分层。CLAD定义为1秒用力呼气量≥20%和/或随访3个月后用力肺活量下降。Kaplan-Meier和多变量Cox模型评估了生存率和覆层风险,并按种族和民族进行了亚组分析。结果在分析的18199例患者中,3479例(18.3%)患有糖尿病。糖尿病患者的覆层率较高(21.3% vs 17.4%, P = 0.003)。DM患者在72小时内3级原发性移植物功能障碍更为常见(20.3% vs 17.1%, P = 0.03)。此外,糖尿病患者的5年总生存率较低(55.2% vs 58.7%, P = 0.003)。在多因素分析中,DM与5年死亡风险增加(风险比2.58,P = 0.004)和CLAD(优势比1.46,P = 0.03)相关。值得注意的是,在糖尿病患者中,与其他种族相比,亚洲患者的5年生存率显著降低(P = 0.024)。在糖尿病患者中,亚洲人身份与死亡风险增加独立相关(风险比1.72,P = 0.002)。结论:受体DM与肺移植术后长期生存和慢性肺衰竭风险降低有关。美籍亚裔糖尿病患者的生存率明显较低,提示种族、民族和代谢状态之间存在潜在的相互作用。
{"title":"The Impact of Preexisting Diabetes Mellitus on Chronic Lung Allograft Dysfunction After Lung Transplantation","authors":"Ye In Christopher Kwon BA,&nbsp;Michael Keller BS,&nbsp;Holly Caboti-Jones BS,&nbsp;Matthew Ambrosio MS,&nbsp;Barry C. Gibney DO,&nbsp;Luca Paoletti MD,&nbsp;Rachit D. Shah MD,&nbsp;Vipul Patel MD,&nbsp;Vigneshwar Kasirajan MD,&nbsp;Zubair A. Hashmi MD","doi":"10.1016/j.atssr.2026.02.029","DOIUrl":"10.1016/j.atssr.2026.02.029","url":null,"abstract":"<div><h3>Background</h3><div>Chronic lung allograft dysfunction (CLAD) remains a major cause of mortality after lung transplantation. Diabetes mellitus (DM) may contribute to CLAD through metabolic dysregulation. We evaluated post–lung transplant outcomes in recipients with DM.</div></div><div><h3>Methods</h3><div>Adults undergoing first-time, isolated lung transplant (November 2017 to December 2024) with at least 6 months of follow-up were identified in the United Network for Organ Sharing registry and stratified by DM diagnosis at waitlist registration. CLAD was defined as ≥20% forced expiratory volume in 1 second and/or forced vital capacity decline after &gt;3 months follow-up. Kaplan-Meier and multivariable Cox models assessed survival and CLAD risk, with subgroup analysis by race and ethnicity.</div></div><div><h3>Results</h3><div>Among 18,199 analyzed patients, 3479 (18.3%) had DM. CLAD rates were higher among recipients with DM (21.3% vs 17.4%, <em>P</em> = .003). Grade 3 primary graft dysfunction at 72 hours was more frequent among recipients with DM (20.3% vs 17.1%, <em>P</em> = .03). Additionally, 5-year overall survival was lower in DM patients (55.2% vs 58.7%, <em>P</em> = .003). On multivariate analysis, DM was associated with increased risk of 5-year mortality (hazard ratio, 2.58, <em>P</em> = .004) and CLAD (odds ratio, 1.46, <em>P</em> = .03). Notably, in patients with DM, 5-year survival was significantly decreased among Asian patients (<em>P</em> = .024) compared with other races. Among patients with DM, Asian status was independently associated with increased risk of mortality (hazard ratio, 1.72, <em>P</em> = .002).</div></div><div><h3>Conclusions</h3><div>Recipient DM is associated with reduced long-term survival and CLAD risk after lung transplant. Asian American recipients with DM appear to face disproportionately worse survival, suggesting a potential interaction between race, ethnicity, and metabolic status.</div></div>","PeriodicalId":72234,"journal":{"name":"Annals of thoracic surgery short reports","volume":"4 3","pages":"Pages 1027-1032"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Annals of thoracic surgery short reports
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