提高归国华侨对 SARS-CoV-2 的免疫力。

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-01-08 DOI:10.1080/21645515.2023.2300208
Runyu Yuan, Huimin Chen, Lina Yi, Xinxin Li, Ximing Hu, Xing Li, Huan Zhang, Pingping Zhou, Chumin Liang, Huifang Lin, Lilian Zeng, Xue Zhuang, QianQian Ruan, Yueling Chen, Yingyin Deng, Zhe Liu, Jing Lu, Jianpeng Xiao, Liang Chen, Xincai Xiao, Jing Li, Baisheng Li, Yan Li, Jianfeng He, Jiufeng Sun
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引用次数: 0

摘要

全球 COVID-19 疫苗接种计划有效遏制了 SARS-CoV-2 的快速传播。了解回国人群的免疫状况将有助于了解群体免疫的实现情况和中国 COVID-19 的长期管理。研究人员从中国广州的 7 个隔离检疫站招募人员。采集了参与者的血液和咽拭子标本,并通过竞争性酶联免疫吸附试验、微中和试验和酶联荧光斑点试验确定了他们的免疫状况。共有 272 名受试者参与了问卷调查,其中 235 人(86.4%)为归国华侨,37 人(13.6%)为外国人。从 108 名归国华侨中采集了血液和咽拭子标本。在约 90% 的归国华侨中检测到了 SARS-CoV-2 的中和抗体,无论是初种组还是同种异源加强免疫组。与原型病毒相比,血清中针对 SARS-CoV-2 Omicron BA.5、BF.7、BQ.1 和 XBB.1 的 NAb 滴度明显下降。然而,两组的记忆 T 细胞反应,包括特异性 IFN-γ 和 IL-2 反应,并无差异。吸烟、饮酒、SARS-CoV-2 感染、COVID-19 疫苗接种以及最后一次接种与采样之间的时间间隔是影响针对原型 SARS-CoV-2 和相关变种的 NAb 滴度的独立影响因素。疫苗剂量是 Omicron 亚变种的唯一共同影响因素。在再次感染和接种疫苗的归国华侨中建立了对 SARS-CoV-2 的增强免疫力。中国重新开放后,国内居民将受益于同源或异源 COVID-19 强化接种,这对预防突破性感染也很有用。
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Enhanced immunity against SARS-CoV-2 in returning Chinese individuals.

Global COVID-19 vaccination programs effectively contained the fast spread of SARS-CoV-2. Characterizing the immunity status of returned populations will favor understanding the achievement of herd immunity and long-term management of COVID-19 in China. Individuals were recruited from 7 quarantine stations in Guangzhou, China. Blood and throat swab specimens were collected from participants, and their immunity status was determined through competitive ELISA, microneutralization assay and enzyme-linked FluoroSpot assay. A total of 272 subjects were involved in the questionnaire survey, of whom 235 (86.4%) were returning Chinese individuals and 37 (13.6%) were foreigners. Blood and throat swab specimens were collected from 108 returning Chinese individuals. Neutralizing antibodies against SARS-CoV-2 were detected in ~90% of returning Chinese individuals, either in the primary or the homologous and heterologous booster vaccination group. The serum NAb titers were significantly decreased against SARS-CoV-2 Omicron BA.5, BF.7, BQ.1 and XBB.1 compared with the prototype virus. However, memory T-cell responses, including specific IFN-γ and IL-2 responses, were not different in either group. Smoking, alcohol consumption, SARS-CoV-2 infection, COVID-19 vaccination, and the time interval between last vaccination and sampling were independent influencing factors for NAb titers against prototype SARS-CoV-2 and variants of concern. The vaccine dose was the unique common influencing factor for Omicron subvariants. Enhanced immunity against SARS-CoV-2 was established in returning Chinese individuals who were exposed to reinfection and vaccination. Domestic residents will benefit from booster homologous or heterologous COVID-19 vaccination after reopening of China, which is also useful against breakthrough infection.

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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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