在不同 CD4+ T 淋巴细胞数量的 HIV 感染者中接种异源疫苗 CoronaVac(希诺威)和 Vaxzevria(阿斯利康)后的免疫原性和中和抗体反应比较。

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-01-31 DOI:10.1080/21645515.2024.2309734
Sorawit Chittrakarn, Pisud Siripaitoon, Sarunyou Chusri, Siripen Kanchanasuwan, Boonsri Charoenmak, Thanaporn Hortiwakul, Phaiwon Kantikit, Narongdet Kositpantawong
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引用次数: 0

摘要

艾滋病病毒感染者(PLWH)对异源冠状病毒病(COVID-19)疫苗接种的免疫反应尚不清楚。在此,我们的前瞻性队列研究旨在比较 CD4 细胞数≤ 200 cells/µL(低 CD4+)和大于 200 cells/µL(高 CD4+)的艾滋病病毒感染者接种冠状病毒(COVID-19)异源疫苗后的免疫反应。免疫2周和12周后,对抗受体结合域(RBD)免疫球蛋白G(IgG)水平和中和抗体(nAbs)抑制百分比进行分析。低 CD4+ 组和高 CD4+ 组参与者的平均 CD4+ 细胞数分别为 139 和 575 cells/µL。免疫2周和12周后,低CD4组的抗RBD-IgG水平中位数分别为159 IU/mL和143 IU/mL,而nAb水平分别为71%和47.2%。相反,高 CD4+ 组的抗 RBD-IgG 水平中位数分别为 273 IU/mL 和 294 IU/mL,而 nAb 水平为 89.3%,相对稳定在 81.6%。不过,虽然两个研究组之间的免疫反应没有显著差异,但在 12 周时,低 CD4+ 组的 nAb 水平出现了下降。因此,建议接种 COVID-19 加强剂量疫苗以获得免疫保护。
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Comparative immunogenicity and neutralizing antibody responses post heterologous vaccination with CoronaVac (Sinovac) and Vaxzevria (AstraZeneca) in HIV-infected patients with varying CD4+ T lymphocyte counts.

The immune response to heterologous coronavirus disease (COVID-19) vaccination in people living with HIV (PLWH) is still unclear. Herein, our prospective cohort study aimed to compare the immune response of heterologous vaccination with CoronaVac (Sinovac) and Vaxzevria (AstraZeneca) between PLWH having CD4 counts ≤ 200 cells/µL (low CD4+) and > 200 cells/µL (high CD4+). Anti-receptor-binding domain (RBD) immunoglobulin G (IgG) levels and the percentage inhibition of neutralizing antibodies (nAbs) were analyzed at 2 and 12 weeks after immunization. Participants in the low and high CD4+ groups had mean CD4+ counts of 139 and 575 cell/µL, respectively. Two and 12 weeks after immunization, in the low CD4 group, the median anti-RBD-IgG levels were 159 IU/mL and 143 IU/mL, respectively, whereas the nAb level was 71% and decreased to 47.2%, respectively. Contrarily, the median anti-RBD-IgG levels in the high CD4+ group were 273 IU/mL and 294 IU/mL, respectively, whereas the nAb levels were 89.3% and relatively stable at 81.6%. However, although immune responses between the two study groups were not significantly different, a decline in nAb levels was observed at 12 weeks in the low CD4+ group. Therefore, a COVID-19 booster vaccine dose is suggested for immunoprotection.

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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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