COVID-19 疫苗接种情况对住院和疾病严重程度的影响:日本长崎县的一项描述性研究。

IF 4.1 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Human Vaccines & Immunotherapeutics Pub Date : 2024-12-31 Epub Date: 2024-03-22 DOI:10.1080/21645515.2024.2322795
Guoxi Cai, Shiwen Liu, Yixiao Lu, Yumika Takaki, Fumiaki Matsumoto, Akira Yoshikawa, Toshitsugu Taguri, Jianfen Xie, Kazuhiko Arima, Satoshi Mizukami, Jiwen Wu, Taro Yamamoto, Maiko Hasegawa, Nguyen Tien Huy, Masaya Saito, Shouhei Takeuchi, Kouichi Morita, Kiyoshi Aoyagi, Fei He
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引用次数: 0

摘要

冠状病毒病 2019(COVID-19)危害极大,感染率和住院率都很高。本研究旨在利用日本长崎县的数据,评估 COVID-19 疫苗接种情况和其他因素对住院治疗和疾病严重程度的影响。研究纳入了有疫苗接种情况的 COVID-19 确诊感染病例,并分析了不同疫苗接种情况、是否住院以及疾病严重程度不同的患者之间的特征差异。此外,该研究还采用逻辑回归法计算几率比(ORs)和95%置信区间(CI),以评估各种因素与住院和疾病严重程度的关系。从2020年3月14日至2022年8月31日,23139名患者未接种疫苗,13668名患者接种了一剂或两剂初级疫苗,4575名患者完成了加强接种。接种疫苗可降低住院风险,奇异比为 0.759(95% CI:0.654-0.881),完成加强接种的保护效果更为明显(OR:0.261,95% CI:0.207-0.328)。同样,接种疫苗也大大降低了疾病严重程度的风险(接种疫苗的初级项目:OR:0.191,95% CI:0.207-0.328):OR:0.191,95% CI:0.160-0.228;完成加强免疫:OR:0.129,95% CI:0.099-0.169)。总体而言,未接种疫苗、男性、老年人、免疫力低下者、肥胖者以及有其他严重疾病因素的患者都是COVID-19相关住院和疾病严重程度的危险因素。接种疫苗可降低住院风险和疾病严重程度,并突出了完成加强接种的益处。
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Impact of COVID-19 vaccination status on hospitalization and disease severity: A descriptive study in Nagasaki Prefecture, Japan.

Coronavirus disease 2019 (COVID-19) was extraordinarily harmful, with high rates of infection and hospitalization. This study aimed to evaluate the impact of COVID-19 vaccination status and other factors on hospitalization and disease severity, using data from Nagasaki Prefecture, Japan. Confirmed cases of COVID-19 infection with vaccination status were included and the differences in characteristics between different vaccination statuses, hospitalization or not, and patients with varying levels of disease severity were analyzed. Furthermore, logistic regression was used to calculate odds ratio (ORs) and 95% confidence intervals (CI) to evaluate the association of various factors with hospitalization and disease severity. From March 14, 2020 to August 31, 2022, 23,139 patients were unvaccinated 13,668 vaccinated the primary program with one or two doses, and 4,575 completed the booster. Vaccination reduced the risk of hospitalization with an odd ratio of 0.759 (95% CI: 0.654-0.881) and the protective effect of completed booster vaccination was more pronounced (OR: 0.261, 95% CI: 0.207-0.328). Similarly, vaccination significantly reduced the risk of disease severity (vaccinated primary program: OR: 0.191, 95% CI: 0.160-0.228; completed booster vaccination: OR: 0.129, 95% CI: 0.099-0.169). Overall, unvaccinated, male, elderly, immunocompromised, obese, and patients with other severe illness factors were all risk factors for COVID-19-related hospitalization and disease severity. Vaccination was associated with a decreased risk of hospitalization and disease severity, and highlighted the benefits of completing booster.

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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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