从口腔微生物群的视角揭示大脑衰老。

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-07-01 Epub Date: 2024-07-10 DOI:10.4103/NRR.NRR-D-23-01761
Qinchao Hu, Si Wang, Weiqi Zhang, Jing Qu, Guang-Hui Liu
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引用次数: 0

摘要

摘要:口腔是一个复杂的生理群落,包含多种微生物。口腔微生物群失调可导致各种口腔感染性疾病,如牙周炎和蛀牙,甚至影响全身健康,包括脑衰老和神经退行性疾病。最近的研究强调了口腔微生物如何可能参与脑衰老和神经退行性疾病,为干预策略指明了潜在的途径。在这篇综述中,我们总结了证明口腔微生物/口腔传染病与脑衰老/神经退行性疾病之间存在联系的临床证据,并剖析了口腔微生物导致脑衰老和神经退行性疾病的潜在机制。我们还重点介绍了基于口腔微生物领域的治疗开发进展,其目标是促进大脑健康和健康老龄化。
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Unraveling brain aging through the lens of oral microbiota.

The oral cavity is a complex physiological community encompassing a wide range of microorganisms. Dysbiosis of oral microbiota can lead to various oral infectious diseases, such as periodontitis and tooth decay, and even affect systemic health, including brain aging and neurodegenerative diseases. Recent studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration, indicating potential avenues for intervention strategies. In this review, we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases, and dissect potential mechanisms by which oral microbes contribute to brain aging and neurodegeneration. We also highlight advances in therapeutic development grounded in the realm of oral microbes, with the goal of advancing brain health and promoting healthy aging.

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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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