利用工程细胞外囊泡作为输送载体治疗缺血性中风:线粒体输送的特殊前景。

IF 5.9 2区 医学 Q2 CELL BIOLOGY Neural Regeneration Research Pub Date : 2025-08-01 Epub Date: 2024-07-29 DOI:10.4103/NRR.NRR-D-24-00243
Jiali Chen, Yiyang Li, Xingping Quan, Jinfen Chen, Yan Han, Li Yang, Manfei Zhou, Greta Seng Peng Mok, Ruibing Wang, Yonghua Zhao
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引用次数: 0

摘要

缺血性中风是全球死亡的次要原因,给社会造成了巨大的医疗和经济负担。细胞外囊泡是天然的纳米药物载体,在体内具有良好的生物相容性,在治疗缺血性中风方面具有显著优势。然而,细胞外囊泡的分布不确定和快速清除阻碍了它们的递送效率。利用膜装饰或将治疗货物封装在细胞外囊泡中,可大大提高其输送效率。此外,先前的研究表明,大尺寸细胞外囊泡的一个子集--微囊泡可以将线粒体运送到邻近细胞,从而帮助恢复缺血性中风后的线粒体功能。小型细胞外囊泡也已证明有能力转运线粒体成分,如蛋白质或脱氧核糖核酸,或其子成分,用于基于细胞外囊泡的缺血性中风治疗。在这篇综述中,我们对细胞外囊泡的分离技术进行了比较分析,并概述了目前主流的细胞外囊泡修饰方法。鉴于缺血性中风治疗的复杂性,我们还划分了适合治疗过程不同方面的各种细胞外囊泡修饰方法。此外,鉴于人们对线粒体输送的兴趣日渐浓厚,我们深入研究了通过小型细胞外囊泡和微囊泡输送线粒体组分或完整线粒体的可行性和现有研究成果,为缺血性中风治疗提供了一个全新的视角。
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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery.

Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke. However, the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency. By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles, their delivery efficacy may be greatly improved. Furthermore, previous studies have indicated that microvesicles, a subset of large-sized extracellular vesicles, can transport mitochondria to neighboring cells, thereby aiding in the restoration of mitochondrial function post-ischemic stroke. Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components, such as proteins or deoxyribonucleic acid, or their sub-components, for extracellular vesicle-based ischemic stroke therapy. In this review, we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies. Given the complex facets of treating ischemic stroke, we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process. Moreover, given the burgeoning interest in mitochondrial delivery, we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

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来源期刊
Neural Regeneration Research
Neural Regeneration Research CELL BIOLOGY-NEUROSCIENCES
CiteScore
8.00
自引率
9.80%
发文量
515
审稿时长
1.0 months
期刊介绍: Neural Regeneration Research (NRR) is the Open Access journal specializing in neural regeneration and indexed by SCI-E and PubMed. The journal is committed to publishing articles on basic pathobiology of injury, repair and protection to the nervous system, while considering preclinical and clinical trials targeted at improving traumatically injuried patients and patients with neurodegenerative diseases.
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