活性氧介导的有机长效发光体点亮生物医学:从双组分分离式纳米系统到集成式单发光体。

IF 40.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical Society Reviews Pub Date : 2024-10-04 DOI:10.1039/D4CS00443D
Zhe Li, Hongwen Liu and Xiao-Bing Zhang
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引用次数: 0

摘要

有机发光体已被广泛应用于细胞和体内荧光成像,但也面临着极大的挑战,包括信噪比(SNR)较低,甚至由于实时激发激光产生的不可忽略的背景信号而出现假信号。为了克服这些挑战,近十年来,功能化有机长效发光体备受关注。这类发光体不仅能克服无机长效发光材料的生物毒性(代谢毒性和无机重金属的泄漏风险),还能在移除激发光源后继续发出长效发光,从而有效提高成像质量。更重要的是,有机长效发光体具有良好的结构定制性,可用于构建可激活探针,有利于生物传感。近年来,活性氧(ROS)介导的长效(ROSLP)发光体(尤其是有机小分子 ROSLP 发光体)的发展仍处于上升阶段。值得注意的是,用于体内成像的 ROSLP 发光体经历了从双组分分离纳米系统到集成单发光体的过程,逐渐获得了更好的可设计性和生物相容性。在这篇综述中,我们总结了有机长效发光体的发展历程、长效发光工作机理和生物医学应用,总结了有机长效发光体的进展和挑战。我们希望这些见解能帮助科学家进一步开发生物医学领域的功能化有机长效发光体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Reactive oxygen species-mediated organic long-persistent luminophores light up biomedicine: from two-component separated nano-systems to integrated uni-luminophores

Organic luminophores have been widely utilized in cells and in vivo fluorescence imaging but face extreme challenges, including a low signal-to-noise ratio (SNR) and even false signals, due to non-negligible background signals derived from real-time excitation lasers. To overcome these challenges, in the last decade, functionalized organic long-persistent luminophores have gained much attention. Such luminophores could not only overcome the biological toxicity of inorganic long-persistent luminescent materials (metabolic toxicity and leakage risk of inorganic heavy metals), but also continue to emit long-persistent luminescence after removing the excitation source, thus effectively improving imaging quality. More importantly, organic long-persistent luminophores have good structure tailorability for the construction of activable probes, which is favorable for biosensing. Recently, the development of reactive oxygen species (ROS)-mediated long-persistent (ROSLP) luminophores (especially organic small-molecule ROSLP luminophores) is still in the rising stage. Notably, ROSLP luminophores for in vivo imaging have experienced from two-component separated nano-systems to integrated uni-luminophores, which obtained gradually better designability and biocompatibility. In this review, we summarize the progress and challenges of organic long-persistent luminophores, focusing on their development history, long-persistent luminescence working mechanisms, and biomedical applications. We hope that these insights will help scientists further develop functionalized organic long-persistent luminophores for the biomedical field.

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来源期刊
Chemical Society Reviews
Chemical Society Reviews 化学-化学综合
CiteScore
80.80
自引率
1.10%
发文量
345
审稿时长
6.0 months
期刊介绍: Chemical Society Reviews is published by: Royal Society of Chemistry. Focus: Review articles on topics of current interest in chemistry; Predecessors: Quarterly Reviews, Chemical Society (1947–1971); Current title: Since 1971; Impact factor: 60.615 (2021); Themed issues: Occasional themed issues on new and emerging areas of research in the chemical sciences
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