Fangfang Sun, Bingjie Han, Yi Zhao, Xing Chen, Hui Tian, Chenghui Liu, Yuanyuan Sun
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Thermus thermophilus Argonaute (TtAgo) Cleavage-Aided Isothermal Amplification Strategy (TAC-IAS) for precise detection of locus-specific DNA methylation
A versatile TtAgo cleavage-aided isothermal amplification strategy (TAC-IAS) is devised for DNA methylation precise detection with high flexibility and universality compared to methylation-restriction endonuclease, reliably identifying methylation with an abundance of 0.1% in a large pool of unmethylated fragments.
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