甘氨酸衍生物原位生成NHPl酯的可见光驱动C（sp³）-H脱羧烷基化反应

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Communications Pub Date : 2025-06-09 DOI:10.1039/D5CC02375K

Lan Yang, Yi-Yang Tang, Si-Yu Gao and Peng-Lin Zhang

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引用次数: 0

摘要

通过原位形成NHPl酯的甘氨酸衍生物的可见光驱动脱羧C（sp³）-H烷基化。采用Xantphos/ICH₂CH₂I体系作为双活化剂和催化剂，避免了昂贵的光催化剂和过渡金属。在温和的条件下，建立了一个通用的平台，从容易获得的具有高官能团耐受性的烷基羧酸合成非天然氨基酸。

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Visible-light-driven decarboxylative C(sp3)–H alkylation of glycine derivatives via in situ formation of NHPI esters†

A visible-light-driven decarboxylative C(sp³)–H alkylation of glycine derivatives via in situ formation of NHPI esters is reported. The use of the Xantphos/ICH₂CH₂I system as a dual activator and a catalyst eliminates the need for expensive photocatalysts and transition metals. Under mild conditions, a versatile platform is established for synthesizing unnatural amino acids from readily available alkyl carboxylic acids with high functional group tolerance.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.