Goh Sennari, Akito Watanabe, Takanori Ōno, Jun Oshita, Yoshihiko Noguchi, Tomoyasu Hirose and Toshiaki Sunazuka
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Macrocyclic skeletal modification approach to the anti-trypanosomal macrolides, actinoallolides†
Herein, we report the construction of 16-membered macrocycles that were designed as intermediates toward the unified synthesis of actinoallolides. Key to our synthesis was the use of Mitsunobu macrocyclization, followed by a sequence of Birch reduction and oxidative C–C cleavage to edit the macrocycle.
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