Generation of antibody–drug conjugates by proximity-driven acyl transfer and sortase-mediated ligation?

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DOI:10.1039/d4ob01624f
作者：Zhi-Hui Cui ,&nbsp;Hua Zhang ,&nbsp;Feng-Hao Zheng ,&nbsp;Jun-Hao Xue ,&nbsp;Qing-Hong Yin ,&nbsp;Xiao-Lei Xie ,&nbsp;Yu-Xuan Wang ,&nbsp;Tao Wang ,&nbsp;Li Zhou ,&
文献类型：期刊论文
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Royal Society of Chemistry (RSC)

Abstract：We report a sortase-based site-specific antibody–drug conjugation strategy, which involves an affinity peptide-directed acyl transfer reaction and sortase-mediated peptide ligation. Through

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