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Nat Chem Biol丨冯世庆/孙金鹏/肖鹏/林慧/于晓发现一种有治疗作用的粘附类GPCR别构纳米抗体
Nat Chem Biol丨冯世庆/孙金鹏/肖鹏/林慧/于晓发现一种有治疗作用的粘附类GPCR别构纳米抗体
G蛋白偶联受体(GPCRs)调节哺乳动物几乎每一个生理过程,是超过30%药物的靶点。GPCR的别构调节剂因其独特的药理优势备受关注,因为它们能够保持内源性配体的信号转导特性,减少副作用,拓宽信号转导的
BioArt公众号 36分钟前
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Nature丨基于R2逆转录转座子的新型基因编辑系统“STITCHR”
Nature丨基于R2逆转录转座子的新型基因编辑系统“STITCHR”
撰文丨易真核生物基因组处于动态变化之中,转座子的活动是塑造基因组结构的重要驱动力之一。其中,非长末端重复逆转录转座子(non-LTR retrotransposons)通过“复制-粘贴”机制在基因组中
BioArt公众号 36分钟前
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Cell丨解析人类趋化因子- GPCR相互作用网络
Cell丨解析人类趋化因子- GPCR相互作用网络
撰文丨我的闺蜜老红帽在人类中,细胞迁移是通过分泌的趋化因子(配体)与其在迁移细胞表面表达的趋化因子受体之间的相互作用来协调的,而趋化因子受体往往来自于G蛋白偶联受体(GPCR)超家族。如下图所示,趋化
BioArt公众号 36分钟前
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Science丨小真菌蕴藏大奥秘,张跃林教授团队揭示全新生存策略
Science丨小真菌蕴藏大奥秘,张跃林教授团队揭示全新生存策略
在细胞分裂过程中,染色体的精确分配对于维持生物体的遗传稳定性和功能完整性至关重要。按照经典理论,有丝分裂或减数分裂后,每个子细胞核应当至少获得完整的一套单倍体染色体(1N),以确保细胞正常发育和功能发
BioArt公众号 36分钟前
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NEJM丨司美格鲁肽治疗代谢功能障碍相关脂肪性肝炎的III期临床试验
NEJM丨司美格鲁肽治疗代谢功能障碍相关脂肪性肝炎的III期临床试验
撰文丨菠萝西瓜代谢功能障碍相关脂肪性肝炎(MASH),以前称为非酒精性脂肪性肝炎,是一种严重的代谢功能障碍相关脂肪性肝病(MASLD),其特征是脂肪变性、肝细胞损伤和炎症。脂肪性肝炎会促进肝纤维化、进
BioArt公众号 36分钟前
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Nature | RAD52双环结构重塑复制叉,限制复制叉反转
Nature | RAD52双环结构重塑复制叉,限制复制叉反转
撰文 | 染色体RAD52是一种多功能DNA修复蛋白,广泛参与维护基因组稳定性的多种细胞过程【1】。在复制应激条件下,RAD52能够结合并稳定停滞的复制叉,防止其被SMARCAL1分子马达介导发生反转
BioArt公众号 36分钟前
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Cancer Discovery丨一款人源化CD36阻断抗体PLT012可有效激发针对肝癌和肝转移的抗肿瘤免疫力
Cancer Discovery丨一款人源化CD36阻断抗体PLT012可有效激发针对肝癌和肝转移的抗肿瘤免疫力
撰文丨菠萝西瓜癌细胞的代谢转化受致癌驱动突变和免疫代谢编辑控制,并与肿瘤细胞在肿瘤微环境(TME)中的存活相关。代谢重编程已被证明能够调节肿瘤生长、抗凋亡机制和免疫逃逸。值得注意的是,脂质代谢重编程是
BioArt公众号 36分钟前
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顾家宁 | 心气理之间:政教视野下的黄宗羲哲学建构
顾家宁 | 心气理之间:政教视野下的黄宗羲哲学建构
中国社会科学院哲学研究所主办心气理之间:政教视野下的黄宗羲哲学建构顾家宁 | 文作者简介顾家宁,1986年1月出生,浙江金华人,中国人民大学国学院历史学博士,达特茅斯学院亚洲与中东语言文学系访问学者(
哲学研究公众号 52分钟前
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清华深研院周光敏Angew: 基于解析锂-二氧化碳电池负极降解机制的大气响应型保护策略
清华深研院周光敏Angew: 基于解析锂-二氧化碳电池负极降解机制的大气响应型保护策略
【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!速抢!5月计算福利大放价,催化/电池6折最后10个名额!锂-二氧化碳(Li-CO₂)电池具有高理论能量密度
顶刊收割机公众号 56分钟前
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别再烧秸秆了!福建农林大学,第一单位发表Science子刊!博士生龚正刚一作!
别再烧秸秆了!福建农林大学,第一单位发表Science子刊!博士生龚正刚一作!
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顶刊收割机公众号 56分钟前
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双层石墨烯,Nature Materials!
双层石墨烯,Nature Materials!
【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!速抢!5月计算福利大放价,催化/电池6折最后10个名额!莫尔超晶格是一种由两个或多个二维原子晶体在存在小角
顶刊收割机公众号 56分钟前
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南航张腾飞/东南大学章炜/复旦大学余学斌,最新Nature子刊!
南航张腾飞/东南大学章炜/复旦大学余学斌,最新Nature子刊!
【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!速抢!5月计算福利大放价,催化/电池6折最后10个名额!随着电动汽车和便携电子设备对高能量密度电池需求的激
顶刊收割机公众号 56分钟前
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【最后3天】接顶刊好运!客户发了Nature Materials,同款催化/电池计算6折即将截单!
【最后3天】接顶刊好运!客户发了Nature Materials,同款催化/电池计算6折即将截单!
又传喜报!客户发了Nature Materials华算科技专业靠谱,审稿没有提计算问题为助力科研加速,特推出福利 催化/电池计算全场6⃣折 ✅催化计算:吸附能、态密度、d带中心、COHP、能
顶刊收割机公众号 56分钟前
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北京化工大学胡君教授团队 Small:兼具高拉伸与稳固界面性的一体化拉胀导电弹性体复合材料
北京化工大学胡君教授团队 Small:兼具高拉伸与稳固界面性的一体化拉胀导电弹性体复合材料
拉胀导电弹性体是一类具有负泊松比特性和导电功能的机械超材料,在柔性传感器、可穿戴设备和可拉伸显示器等领域展现出独特的应用潜力。目前,拉胀导电弹性体通常是在传统导电弹性体中引入
高分子科技公众号 1小时前
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华科大龚江课题组 ACB:在常压空气氛围、无溶剂条件下ZnO催化废弃PET连续降解
华科大龚江课题组 ACB:在常压空气氛围、无溶剂条件下ZnO催化废弃PET连续降解
催化氢解是一种将废弃聚对苯二甲酸乙二醇酯(PET)升级回收为对苯二甲酸的有前景策略,但该技术面临两大瓶颈:(1)需使用高压易燃H2,(2)因H2在PET熔体中扩散缓慢导致PE
高分子科技公众号 1小时前
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兰州大学吕少瑜教授 AFM:用于极端环境救援的多功能光学离子凝胶
兰州大学吕少瑜教授 AFM:用于极端环境救援的多功能光学离子凝胶
激发波长依赖(Ex-De)材料通过调节激发能量输入,可轻松、快速地实现多色发射,成为多功能光学材料研究的新方向。然而,传统Ex-De材料的实际应用长期受限于制备工艺复杂、环境
高分子科技公众号 1小时前
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Nat Commun|北京大学裴剑锋等:药效团驱动的分子生成模型TransPharmer
Nat Commun|北京大学裴剑锋等:药效团驱动的分子生成模型TransPharmer
分子生成模型在药物设计中表现出强大的效率,但生成的化合物却往往缺乏结构新颖性。从已知结构出发搜索邻域是一种常见探索化学空间的方法,但该方法存在一定的局限性,如探索方向的任意性和效率低下。为解决这一问题
智药邦公众号 1小时前
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GCB | 温带森林碳固存稳定性影响机制
GCB | 温带森林碳固存稳定性影响机制
近日,北京林业大学全国高校黄大年式教师团队、国家林草局林业和草原科技创新团队——林学院森林经理学科森林经营教师团队,在气候变化对多维生物多样性及森林碳固存稳定性的跨尺度影响机制上取得了新进展。研究成果
Wiley生态环境公众号 1小时前
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Med综述|类器官和器官芯片的进展、在药物开发中的应用以及监管挑战
Med综述|类器官和器官芯片的进展、在药物开发中的应用以及监管挑战
类器官(Organoid)和器官芯片(OoC)是用于构建微型人体组织模型的快速发展的技术。它们能够模拟复杂的生理功能和病理状况,为疾病建模、药物筛选、精准医疗和再生疗法提供了更真实的平台。《FDA现代
智药邦公众号 1小时前
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PRL 经典流体的超密度泛函理论:提取对势
PRL 经典流体的超密度泛函理论:提取对势
央企首次发布!材料领域“十大基础科学问题”买科研服务(代计算、代测试、超算机时),送老李校长“科研理工男士情感课”第一性原理计算解决50年悬而未决难题:半导体中铜为何扩散更快?Ab initio及第一
计算材料学公众号 1小时前
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Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
Issue 4 - Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.005

Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms.

Rehabilitation and physiotherapists in the critical care medicine.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.006
European guidelines for the management of tuberculosis screening procedures in migrants: A systematic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2025.2482855

Background: This systematic review assesses the current available evidence across the WHO European region on the effectiveness and cost-effectiveness of the different approaches used for TB screening and also explores the facilitators and barriers that migrants face during screening programmes.

Methods: We conducted an extensive, comprehensive, and systematic literature search across multiple databases, including MEDLINE, Cochrane, Scopus, and ISI Web of Knowledge, without any restrictions on publication date or language. In addition, we reviewed grey literature and reports. The data were meticulously analysed with a focus on screening of TB active disease and infection effectiveness indicators, and cost-effectiveness economic analyses as a primary objective and the comprehension of barriers and facilitators of screening as a secondary objective.

Findings: Our review included 43 studies covering over 8 million migrants from 11 countries. The findings demonstrate that while screening uptake was high, coverage varied, and completion rates for preventive treatments were low. Economic analyses supported the high cost-effectiveness of the screening programmes, particularly when integrating both active TB and TBI screening strategies.

Interpretation: This review underscores the cost-effectiveness and public health importance of TB screening in migrant populations within Europe. However, the disparities in screening practices highlight the urgent need for standardisation at the European level.

Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Influenza's silent toll: A closer look at individuals aged 75 years or older.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2411809
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