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文献分享 |同源转录因子AtCBF2/3/1和OsDREB1C的功能分化
文献分享 |同源转录因子AtCBF2/3/1和OsDREB1C的功能分化
本期分享的文献是 2024 年 5 月发表在 Molecular Biology and Evolution 上的一篇论文,文章标题为" Functional Divergence in Orthol
林木多组学研究公众号 04-05
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高效产氢!他,博毕即任教211,6年即「国家优青」,北工大,新发Angew!
高效产氢!他,博毕即任教211,6年即「国家优青」,北工大,新发Angew!
【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!4月理论计算重磅加码,疯狂特惠全场直降5000元!氨被认为是氢储存和转化最有前景的候选物之一,但涉及氨分解
顶刊收割机公众号 04-05
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材料人必看!Python+机器学习实战课上线,手把手教你复现顶刊案例!
材料人必看!Python+机器学习实战课上线,手把手教你复现顶刊案例!
2025年伊始,机器学习已在各个领域取得了巨大的发展,当下炙手可热的DeepSeek和Manus,其本质就是机器学习。从科学应用的角度,无论材料、化学、生物、物理、医学、工程等领域,但凡涉及到理论计算
顶刊收割机公众号 04-05
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超超超级好用的3款MS超级脚本,限时下载!
超超超级好用的3款MS超级脚本,限时下载!
对初入门理论计算的小虎斑来说,分子动力学分析可谓是一座大山。相信不少同学都遇到过以下难题: 分子、离子在表面、溶液中的运动轨迹怎么画?分子在表面、纳米管内或跨膜的局域扩散系数咋分析?混合体系中的某类特
顶刊收割机公众号 04-05
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理论计算直降¥5000!科研人直呼:这数据终于跑得动了!
理论计算直降¥5000!科研人直呼:这数据终于跑得动了!
华算科技4月福利重磅加码科研征程持续开启专属于科研人的新月特惠理论计算全场直降5000元 截止日期:4月30日 Nature正刊发表经验,计算数据终身质保一站式科研服务,专业又靠谱华算科技助您
顶刊收割机公众号 04-05
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这位“杰出学者”是世界上第一造假王!撤稿量超过 200 次,当前世界纪录已经被刷新至220篇!
这位“杰出学者”是世界上第一造假王!撤稿量超过 200 次,当前世界纪录已经被刷新至220篇!
【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!4月理论计算重磅加码,疯狂特惠全场直降5000元!来源 | Retraction Watch、iMedic
顶刊收割机公众号 04-05
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小白也能懂得机器学习算法介绍
小白也能懂得机器学习算法介绍
想象一下,你教一个孩子识别猫和狗:你不会给他写一本《猫狗鉴别公式手册》,而是给他看大量猫狗图片,让他自己总结规律。机器学习算法就是计算机的“学习指南”——它通过分析数据自动发现规律,最终学会完成预测、
顶刊收割机公众号 04-05
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@科研人,经费预存增值高至17%!全年无忧,狂发顶刊!
@科研人,经费预存增值高至17%!全年无忧,狂发顶刊!
实验室总排队?仪器坏了要送检?财务报销流程太繁琐?一次预存解决你的所有问题!华算科技预存增值持续加码享高至17%增值✅理论计算、测试表征、培训课程均可使用!省去繁琐报账流程加速你的科
顶刊收割机公众号 04-05
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贝森特谈关税与后续计划 | 关税是一次性的价格调整
贝森特谈关税与后续计划 | 关税是一次性的价格调整
译自Bessent今天接受彭博社记者的采访视频主持人:我们将先执行基础关税,接着再实施互惠关税,而每个贸易伙伴的税率都会有些许不同。你是不是已经在准备,在4月9日这些关税生效前,和部分贸易伙伴进行谈判
今日新材料公众号 04-05
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Scott Bessent:美国经济正经历“戒断期”
Scott Bessent:美国经济正经历“戒断期”
美国财政Scott Bessent在3月7日接受CNBC采访中谈及了关税、经济增长、股票市场、美元政策、乌克兰问题等多方面问题,内容比前一天在纽约经济俱乐部的发言更加全面。尽管部分回答有陈词滥调之感,
今日新材料公众号 04-05
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浙江大学,Nature Materials
浙江大学,Nature Materials
特别说明:本文由米测技术中心原创撰写,旨在分享相关科研知识。因学识有限,难免有所疏漏和错误,请读者批判性阅读,也恳请大方之家批评指正。原创丨米测MeLab编辑丨风云研究背景共轭聚合物是有机光电子领域的
纳米人公众号 04-05
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上周刚发Science,John A. Rogers院士,再发Nature!
上周刚发Science,John A. Rogers院士,再发Nature!
推荐阅读:这两位院士合作, 再发一篇Science!研究背景心脏起搏器是治疗心律失常的常见医疗设备,传统的临时起搏器通常通过侵入性手术进行植入,这不仅会带来较大的创伤风险,还可能导致异物排斥和长期依赖
纳米人公众号 04-05
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超导,再发Nature!
超导,再发Nature!
研究背景超导材料因其在能源、医疗、量子计算等领域的广泛应用而备受关注。特别是高温超导材料,其临界温度(Tc)较高,可在相对常规的温度下实现超导状态,具有显著的应用潜力。与传统的超导材料(如铅、锡等)相
纳米人公众号 04-05
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华南理工林志伟团队Science子刊:给DNA拍高清“靓照”,解开领域二十年的未解之谜!
华南理工林志伟团队Science子刊:给DNA拍高清“靓照”,解开领域二十年的未解之谜!
单壁碳纳米管(SWCNTs)凭借其卓越的电学、光学及力学性能,已经在电子器件、光学仪器、疾病检测和能量储存等多个领域得到了广泛应用。然而,常规SWCNTs中包含几十上百种不同手性的组分,这在一定程度上
纳米人公众号 04-05
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代码和数据集均已开源!北京大学博士生一作在一区Top期刊最新研究成果!提出一种全新的多尺度隐自回归时空神经网络架构U-RNN!
代码和数据集均已开源!北京大学博士生一作在一区Top期刊最新研究成果!提出一种全新的多尺度隐自回归时空神经网络架构U-RNN!
近日,北京大学秦华鹏课题组的博士生曹小,在水文领域国际顶级期刊Journal of Hydrology(中科院SCI一区Top刊)上发表了题为“U-RNN high-resolution spati
生态学者公众号 04-05
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宫兰一:马克思主义在中国早期传播的历史考察
宫兰一:马克思主义在中国早期传播的历史考察
作者:宫兰一来源:“史学集刊”微信公众号原文刊载于《史学集刊》2024年第6期近代以来,无数爱国志士一直在探寻行之有效的社会变革理论和民族复兴思想,面对国家蒙辱、人民蒙难、文明蒙尘的局面,振兴中华成为
中国历史研究院公众号 04-05
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钟华:我国考古出土葡萄属种子遗存初探——兼论本土葡萄属植物的栽培可能
钟华:我国考古出土葡萄属种子遗存初探——兼论本土葡萄属植物的栽培可能
作者:钟华来源:“中国社科院考古所中国考古网”微信公众号原文刊载于《中国农史》2024年第6期瑞兽葡萄纹铜镜(图源:湖南省博物馆)一、研究背景近年来,随着考古发现各类植物遗存的日渐丰富,对核果类植物遗
中国历史研究院公众号 04-05
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新方法!看配料表就知食品/饮料健康程度!
新方法!看配料表就知食品/饮料健康程度!
2025年3月28日,美国塔夫茨大学弗里德曼营养科学和政策学院Eden M. Barrett*等在国际营养学Top期刊《The American Journal of Clinical Nutriti
科学私享公众号 04-05
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中科院化学所宋延林/苏萌团队 ACS Nano: 打印类器官的纳米复合水凝胶和微/纳米结构
中科院化学所宋延林/苏萌团队 ACS Nano: 打印类器官的纳米复合水凝胶和微/纳米结构
点击上方“蓝字” 一键订阅传统疾病模型在模拟人体生理和疾病机制方面存在局限,二维细胞培养缺乏细胞间三维相互作用,动物模型与人类存在生理和遗传差异,导致药物开发和疾病建模成功率低。类器官是利用多能干细胞
高分子科技公众号 04-05
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Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.07.004

Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA.

Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day.

Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001).

Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

Issue 4 - Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.005

Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms.

Rehabilitation and physiotherapists in the critical care medicine.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.006
Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Influenza's silent toll: A closer look at individuals aged 75 years or older.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2411809
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