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节奏感不如海狮?海狮Ronan在评估中胜过大学生
节奏感不如海狮?海狮Ronan在评估中胜过大学生
随着音乐的节奏摆动的能力并非人类的专属。比如这只名为Ronan的海狮,在经过训练后,早在3岁时就展现出了令人信服的自适应听觉-运动同步能力。而在十余年后的今天,它的这个能力也一直保持了下来。
Book学术公众号 05-19
考虑热耦合的低温球轴承实时动力学建模
考虑热耦合的低温球轴承实时动力学建模
考虑热耦合的低温球轴承实时动力学建模[美] Pradeep K. Gupta等符号说明c: 比热, J/(kg·)f: 摩擦系数h: 传热系数, W/(m2·)k: 导热系数, W/(m·)m: 质量
轴承杂志社公众号 05-19
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食品领域!2023年度全国各省一等奖名单(25.5.19更新)
食品领域!2023年度全国各省一等奖名单(25.5.19更新)
ScienceShare | 科学私享2023年度全国各省级科学技术奖:一等奖获奖名单汇总(食品领域)导 读2025年5月17日。2025年度国家科学技术奖启动,随着国奖含金量的提高,许多省科技厅征
科学私享公众号 05-19
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四川轻化工大学酿酒专用粮研究团队利用挥发性组学和脂质组学揭示川南酿酒专用粮对浓香型白酒风味形成的影响
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ScienceShare | 科学私享利用挥发性组学和脂质组学揭示川南酿酒专用粮对浓香型白酒风味形成的影响导 读2025年4月,四川轻化工大学酿酒专用粮研究团队在国际权威Top期刊《Food Che
科学私享公众号 05-19
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茅台集团微生物研究团队在国际期刊发表重要成果
茅台集团微生物研究团队在国际期刊发表重要成果
ScienceShare | 科学私享中国白酒微生物组目录及其动态变化机制解析导 读发酵食品为全球人口提供了环境友好且营养丰富的食物,占据了全球食品消费总量的三分之一。微生物作为发酵过程的核心驱动者
科学私享公众号 05-19
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长江大学Food Physics:低频磁场影响铁代谢调节胶红酵母中类胡萝卜素的合成
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长江大学生命科学学院研究团队在期刊Food Physics发表了题为“A low frequency magnetic field regulated the synthesis
科学私享公众号 05-19
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四川农业大学杜晓教授团队Food Chemistry成果:红茶窨制激活代谢途径提升玫瑰花香释放的关键机制
四川农业大学杜晓教授团队Food Chemistry成果:红茶窨制激活代谢途径提升玫瑰花香释放的关键机制
研究亮点20小时窨制时间可优化玫瑰红茶中花香物质的富集。11种芳香挥发物是构成玫瑰红茶特征香气的关键成分。红茶的添加主要激活了玫瑰中的甲基赤藓糖醇磷酸(MEP)代谢途径。研究结论本研究揭示了玫瑰红茶窨
科学私享公众号 05-19
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AC.基于多表位纳米抗体对的新型多重检测平台开发用于快速筛查水传播病原体
AC.基于多表位纳米抗体对的新型多重检测平台开发用于快速筛查水传播病原体
全文简介快速且多重检测水传播病毒对于预防感染至关重要。然而,目前的方法受到低质量探针、仪器依赖以及耗时程序的限制。在本研究中,我们开发了一种基于纳米抗体对的高性能多通道
分析化学方法公众号 05-19
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你心目中的科研是什么颜色?
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致 亲爱的你:今天,是个普通的周一。实验室的离心机还在嗡鸣,培养皿上的菌落逐渐显影。田野调查笔记上的墨迹被晨露晕染,调试窗口不断弹出新的提示。收到“Accepted”的你长舒一口气,休息片刻便投身于点
爱思唯尔Elsevier公众号 05-19
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基金评审专家:两周评审经历这些变化 ...
基金评审专家:两周评审经历这些变化 ...
近日,一位基金评审专家(某账号)于 2025 年 5 月 18 日分享了其基金评审经历与感受。此次评审任务自 5 月 4 日收到基金委邮件提示,至 18 日截止。期间,该专家
高分子科技公众号 05-19
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四川大学肖啸课题组 Nat. Commun.:有机光催化剂助力废弃塑料的升级回收
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一次性塑料由于其轻质、耐用、成本低廉等特性,极大的便利了人类的日常生活,其广泛应用于包装、建筑、汽车、电子和医疗等多个领域。然而,这种大规模生产和使用也带来了日益严重的环境挑
高分子科技公众号 05-19
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DFT算不准能带,那还有什么用呢?
DFT算不准能带,那还有什么用呢?
【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!速抢!5月计算福利大放价,催化/电池6折最后10个名额!本文阐述了使用GGA-PBE泛函进行DFT带隙计算
顶刊收割机公众号 05-19
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范德华校正有什么用?
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【做计算 找华算】理论计算助攻顶刊,50000+成功案例,全职海归技术团队、正版商业软件版权!速抢!5月计算福利大放价,催化/电池6折最后10个名额!本文系统介绍了在密度泛函理论(DFT)中引入范德华
顶刊收割机公众号 05-19
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王琼华团队Light | 厘米级大口径无水电润湿液体透镜
王琼华团队Light | 厘米级大口径无水电润湿液体透镜
Banner导读电润湿液体透镜作为一种新型自适应变焦透镜,具有体积小、易于集成、功耗低、变焦范围大和响应速度快等优势,被广泛应用于成像、医学检测和3D显示等领域。然而,传统的电润湿液体透镜驱动电压高,
中国光学公众号 05-19
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发光学报·封面 | 厦门大学康俊勇团队:用于高效光提取的深紫外LED封装体设计与优化
发光学报·封面 | 厦门大学康俊勇团队:用于高效光提取的深紫外LED封装体设计与优化
Banner导读深紫外光(DUV)在半导体制造、公共卫生和食品安全等领域具有重要应用。随着“水俣公约”的实施,传统汞灯因环境污染问题将逐步被淘汰。以AlGaN为代表的氮化物半导体发光LED,凭借单波长
中国光学公众号 05-19
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吉林大学李文教授团队《Nano Letters》:全水下超强玉米蛋白生物胶粘剂
吉林大学李文教授团队《Nano Letters》:全水下超强玉米蛋白生物胶粘剂
【导语】生物组织密封与修复、骨植入物固定、医疗器械的表面耐久涂层、甚至深海设备维修等都需要具有环境耐受性的超强水下胶粘剂!受自然启发,吉林大学团队成功研发超强全水下蛋白质胶粘剂,不仅粘得牢、耐环境、抗
BioMed科技公众号 05-19
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IF:40.8!上海交通大学,最新STTT,提出GCMN临床用药!
IF:40.8!上海交通大学,最新STTT,提出GCMN临床用药!
巨大先天性黑色素细胞痣(GCMN)的发病机制涉及NRAS、BRAF等基因的体细胞突变,这些突变激活了MAPK和PI3K-AKT信号通路,导致痣细胞的形成。尽管针对这些通路的抑制剂在体外和体内模型中显示
BioMed科技公众号 05-19
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脂质纳米颗粒,最新Nature Cancer!
脂质纳米颗粒,最新Nature Cancer!
CAR T细胞疗法是一种通过改造患者自身的T细胞来攻击癌细胞的免疫治疗方法。然而,该疗法在实体瘤治疗中面临诸多挑战,主要是由于肿瘤抗原的异质性、低表达以及在健康组织中的表达,导致治疗效果不佳和潜在的脱
BioMed科技公众号 05-19
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体内 CAR 工程,最新Nature系列综述!
体内 CAR 工程,最新Nature系列综述!
嵌合抗原受体(CAR)工程化免疫细胞疗法是近年来肿瘤免疫治疗领域的重大突破,尤其在血液系统恶性肿瘤(如急性淋巴细胞白血病、B细胞淋巴瘤和多发性骨髓瘤)中取得了显著疗效。目前已获FDA批准的CAR-T细
BioMed科技公众号 05-19
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中国科学院西安光机所公众科学日暨国际光日主题活动圆满落幕
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2025年5月16日-17日,国际光日与公众科学日适逢其会,中国科学院西安光学精密机械研究所成功举办公众科学日暨国际光日主题活动。本次活动以“光启未来,智创无限”为主题,由中国光学学会高速摄影和光子学
Optica西光所分会公众号 05-19
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FSAP | 上海海洋大学钱韻芳副教授:高含量二氧化碳气调包装对三文鱼肌肉降解及内源酶活性的影响
FSAP | 上海海洋大学钱韻芳副教授:高含量二氧化碳气调包装对三文鱼肌肉降解及内源酶活性的影响
上海海洋大学食品学院钱韻芳副教授等以三文鱼为研究对象,探索了高含量CO2气调包装下三文鱼品质变化、蛋白质降解程度以及内源酶活性的变化,揭示了高含量CO2气调包装三文鱼鱼肉质构软化的机制,为进一步加深对
食品科学杂志公众号 05-19
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Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
Rehabilitation and physiotherapists in the critical care medicine.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.006
Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Influenza's silent toll: A closer look at individuals aged 75 years or older.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2411809
Estimating endurance training intensity prescription from the 6-minute stepper test in people with chronic obstructive pulmonary disease - a multicenter cross-sectional study with external validation.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2025.2486875

Background: Home-based pulmonary rehabilitation (PR) can enhance accessibility to PR, but no at-home field exercise test has been validated for individualized endurance training prescriptions.

Research question: What is the accuracy of the six-minute stepper test (6MST) in estimating endurance training intensity as determined during cardiopulmonary exercise testing (CPET)?

Study design and method: This multicenter (N = 3) cross-sectional study included individuals with COPD. Participants performed CPET and two 6MSTs to evaluate the 6MST's ability to estimate endurance training intensity based on CPET-derived heart rate at the first ventilatory threshold (HRvt1), the corresponding power output (Pvt1), and peak power output (Ppeak). Predictive equations were tested for external validity using data from two prior studies.

Results: 105 patients were included (mean age 61 (SD 9) years; mean FEV1 61 (SD 21) %). Predictive equations moderately predicted HRvt1 (r² = 0.38), strongly predicted Pvt1 (r² = 0.63) and very strongly predicted Ppeak (r² = 0.75). External validity was small to moderate for HRvt1 and Pvt1 but was strong for 60% of Ppeak (mean absolute difference: 10W, 95% CI 5 to 10). Passing and Bablok regression confirmed interchangeability for Pvt1 and 60% of Ppeak.

Interpretation: The 6MST offers a reliable method to set initial training intensity when CPET is unavailable.

Clinical trial registration: NCT02842463.

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.07.004

Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA.

Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day.

Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001).

Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

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