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【往期回顾】叶必丰:基于区域合作思维的跨界污染纠纷处理
【往期回顾】叶必丰:基于区域合作思维的跨界污染纠纷处理
摘要: 在中央与地方事权和财权分立的背景下,地方行政机关是辖区地方利益的主体,实施有关行政行为应符合正当程序,与相邻地方行政机关协商一致;对污染损害的单方面调查或委托鉴定涉嫌当自己案件的法官。法院在民
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Science:中村荣一研究团队揭示晶体可逆双向相变现象
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物质的相变过程通常被认为是单向进行的,例如冰的融化或金属的相变。然而,南开大学讲座教授、东京大学化学系特别教授中村荣一研究团队的最新研究打破了这一传统认知。近期,该研究成果以“Nondetermini
今日新材料公众号 39分钟前
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ACS AMI 亮点速递 | 基于面内铁电极化的二维单层WS₂/PZT异质结的人工突触器件
ACS AMI 亮点速递 | 基于面内铁电极化的二维单层WS₂/PZT异质结的人工突触器件
英文原题:In-plane polarization triggered WS2-ferroelectric heterostructured synaptic devices通讯作者:丛春晓,复旦大
ACS美国化学会公众号 1小时前
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JC|2501|Accounts of Chemical Research, bioRxiv
JC|2501|Accounts of Chemical Research, bioRxiv
2025年1月相关文献导读Accounts of Chemical ResearchVolume 58, Issue 1 Lipid Trafficking in Diverse Bacteria不同
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JC|2501|Cell, Molecular Cell,Nat. Struct. Mol. Biol.
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大连化物所Angew:分子筛催化新进展!
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​Genome Biol | 陈璐/毛亚飞团队利用完整参考基因组精细分析现代人基因组中尼安德特渗入序列
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随着考古学和现代进化遗传学等学科的交叉融合,尼安德特人和丹尼索瓦人等远古人类基因组数据的有效获取使得古人类与现代人类之间的基因混合研究成为可能。相关研究揭示了古人渗入序列在现代人类遗传结构和进化适应中
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德国伊尔梅瑙工业大学雷勇教授研究团队招收国家留学基金委(CSC)公派留学博士生及联合培养博士生
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学校简介德国伊尔梅瑙工业大学(Technical University of Ilmenau)坐落于有“德国绿色心脏”之称的图林根州。伊尔梅瑙因享誉世界的德国诗人歌德而获“歌德大学城”的美誉,作为
研之成理公众号 2小时前
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Angew. Chem.: SMSI新突破:合金催化剂在载体界面的“撕裂效应”首次揭示!
Angew. Chem.: SMSI新突破:合金催化剂在载体界面的“撕裂效应”首次揭示!
▲第一作者:悉尼大学邹思贝博士共同通讯作者:悉尼大学黄骏教授/邹思贝博士;北京工业大学韩晓东教授/李昂教授DOI: https://doi.org/10.1002/anie.202425066目前,在
研之成理公众号 2小时前
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燕山大学/浙江大学合作,Nature Materials!
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▲第一作者:Yeqiang Bu, Zhengping Su, Junquan Huang, Ke Tong通讯作者:Anmin Nie, Hongtao Wang通讯单位:燕山大学,浙江大学DOI:
研之成理公众号 2小时前
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卢旭ACS Catalysis:液态金属催化剂助力高压CO₂电还原
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▲第一作者:朱欣宇 博士研究生通讯作者:房明浩 教授通讯单位:中国地质大学(北京)论文DOI:10.1039/D4TA07453J(点击文末「阅读原文」,直达链接) 全文速览近日,房明浩教授团队发布
研之成理公众号 2小时前
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合肥工业大学仪器学院研发高负载形状记忆微夹持器
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▲第一作者:吴思竹共同通讯作者:张亚超、劳召欣通讯单位:合肥工业大学仪器科学与光电工程学院、安徽省测量理论与精密仪器重点实验室、安徽省智能互联系统实验室论文DOI:10.1002/adfm.20242
研之成理公众号 2小时前
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清华大学,Nature Materials!
清华大学,Nature Materials!
▲第一作者:Rui Wang, Yujie Zhu通讯作者:Qi Li通讯单位:清华大学DOI:10.1038/s41563-025-02130-z(点击文末「阅读原文」,直达链接) 研究背景具有高
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MOFs基材料用于环境污染控制文献整理(2025.2.9-2025.2.15)
MOFs基材料用于环境污染控制文献整理(2025.2.9-2025.2.15)
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水处理文献速递公众号 2小时前
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ES&T|中国地表水中PPDs及PPD-Qs的污染调查
ES&T|中国地表水中PPDs及PPD-Qs的污染调查
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平时大多是在和大家聊环保水处理圈内的那些事,今天跟大家分享分享与我们未来前途相关的事情。刚刚过去的2024年,对于整个行业来说无疑是充满挑战的一年。我们见过太多的岗位&企业在面临裁员又降薪不断。很多水
水处理文献速递公众号 2小时前
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Ceder教授最新Matter:探索LiMXCl4超离子导体族的软摇篮效应和离子输运机理!
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第一性原理计算解决50年悬而未决难题:半导体中铜为何扩散更快?Ab initio及第一性原理入门参考书介绍《海贼王》告诉你,做科研为什么不能闭门造车……来自公众号:能源学人本文以传播知识为目的,如有侵
计算材料学公众号 2小时前
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Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.07.004

Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA.

Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day.

Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001).

Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

Issue 4 - Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.005

Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms.

Rehabilitation and physiotherapists in the critical care medicine.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.006
Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Diagnostic yield and safety of transbronchial lung cryobiopsy for diffuse parenchymal lung diseases diagnosis: Comparison between 1.7-mm and 1.9-mm probes.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.04.003

Purpose of the research: transbronchial lung cryobiopsy has been recently accepted as a valid and less invasive alternative to surgical lung biopsy. The purpose of this randomized controlled study was to evaluate, for the first time, the quality and safety of biopsy specimens obtained by using the new disposable 1.7-mm cryoprobe compared with the standard re-usable 1.9 mm cryoprobe in the diagnosis of diffuse parenchymal lung diseases. Methods: 60 consecutive patients were prospectively enrolled and randomly assigned to two different groups: 1.9 mm (group A) and 1.7 mm (group B); primary endpoints were pathological and multidisciplinary diagnostic yield, sample size and complication rate. Principal results: the pathological diagnostic yield of cryobiopsy was 100% in group A and 93.3% in group B (p = 0.718); cryobiopsy median diameter was 6.8 mm in group A and 6.7 mm in group B (p = 0,5241). Pneumothorax occurred in 9 patients in group A and 10 in group B (p = 0.951); mild-to-moderate bleeding in 7 cases and 9 cases in group A and B respectively (p = 0.559). No death or severe adverse events were observed. Conclusions: there was no statistically significant difference between the two groups, regarding diagnostic yield, adverse events and sampling adequacy.

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