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震惊!2025年影响因子顶级期刊大缩水!而国产期刊IF涨势激烈
震惊!2025年影响因子顶级期刊大缩水!而国产期刊IF涨势激烈
2025年6月18日,科睿唯安(Clarivate Analytics)发布了2024年各大SCI期刊的最新影响因子。在此,小编为大家整理了一下我们熟知的顶级期刊(如 The Lancet(柳叶刀)、Nature、JAMA(美国医学会杂志)、BMJ(英国医学期刊)和 CELL等)与去年相比的影响因子变化。此外,小编也为大家列举了一些优秀的国产期刊,以及不同领域(如生物、化工、食品和材料等)中的TO
Book学术公众号 06-20
研究论文:β相含量对高取向聚偏氟乙烯超薄膜再拉伸过程的α-β相转变影响
研究论文:β相含量对高取向聚偏氟乙烯超薄膜再拉伸过程的α-β相转变影响
文章创新点本工作制备了不同β相含量高取向聚偏氟乙烯(PVDF)超薄膜,研究了再拉伸过程PVDF取向超薄膜中的α相向β相的转变行为,探讨了β相含量对PVDF超薄膜拉伸诱导的α-β相转变影响规律与机制。文
中国高分子公众号 06-20
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靶向脂质纳米颗粒,登上Science正刊!
靶向脂质纳米颗粒,登上Science正刊!
CAR T细胞疗法作为一种革命性的癌症治疗方法,通过改造患者自身的T细胞来攻击癌细胞,在治疗B细胞恶性肿瘤方面取得了显著的成功。然而,其应用受到复杂制造过程、高昂成本、需要淋巴耗竭化疗以及安全性问题的
BioMed科技公众号 06-20
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载药巨噬细胞治疗胶质母细胞瘤,登上Science子刊!
载药巨噬细胞治疗胶质母细胞瘤,登上Science子刊!
胶质母细胞瘤是成人中最常见且最具侵袭性的原发性脑肿瘤,预后极差,目前的治疗方法存在局限性。其治疗面临两大主要挑战:一是药物递送不足,许多有效药物因无法有效穿透血脑屏障或在肿瘤内分布不均而难以发挥作用;
BioMed科技公众号 06-20
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医科院药物所王锐院士/胡宽研究员团队:揭示聚乙二醇化修饰对多肽核药活体命运调控的规律
医科院药物所王锐院士/胡宽研究员团队:揭示聚乙二醇化修饰对多肽核药活体命运调控的规律
两款近年来批准的放射性药物[177Lu]DOTATATE和[177Lu]PSMA-617在肿瘤临床治疗中取得了令人振奋的成绩。其中,用于去势抵抗前列腺癌治疗的[177Lu]PSMA-617在2024年
BioMed科技公众号 06-20
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仰大勇教授课题组AM:DNA纳米框架共递送基因编辑系统和光动力试剂实现胰腺癌精准治疗
仰大勇教授课题组AM:DNA纳米框架共递送基因编辑系统和光动力试剂实现胰腺癌精准治疗
近期,复旦大学仰大勇教授和天津大学姚池教授团队及合作者在胰腺癌精准治疗领域取得新进展。研究团队开发了一种智能DNA纳米框架载体,实现了CRISPR-Cas9基因编辑系统与光动力治疗试剂的可控共递送,显
BioMed科技公众号 06-20
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哀悼!华中农业大学发布讣告
哀悼!华中农业大学发布讣告
南湖新闻网讯 中国共产党优秀党员、教育战线久经考验的忠诚战士,华中农业大学原党委书记孙朝恺同志于2025年6月18日02时40分在武汉逝世,享年92岁。6月20日上午,孙朝恺同志遗体告别仪式在武昌殡仪
溪远讲植物科学公众号 06-20
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又一篇!万建民院士团队再取重要研究进展!
又一篇!万建民院士团队再取重要研究进展!
6月19日,万建民院士团队在水稻抽穗期的调控上取得重要进展。相关成果“ELD1 mediates photoperiodic flowering via OsCCA1 alternative spli
溪远讲植物科学公众号 06-20
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山西稷山考古新发现:东周时期北方旱作农业实证
山西稷山考古新发现:东周时期北方旱作农业实证
6月18日,山西省考古研究院对外发布了山西稷山郭家枣园遗址(2009)东周时期炭化植物遗存分析,认定该地属典型中国北方旱作农业传统。郭家枣园遗址(111°01'26"E,35°26'05"N)位于山西
中国社科院考古所中国考古网公众号 06-20
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袁广阔 宋瑞 | 论中原裴李岗文化对长江中游同时期考古学文化的影响
袁广阔 宋瑞 | 论中原裴李岗文化对长江中游同时期考古学文化的影响
摘要:中原裴李岗文化与长江中游地区的交流互动,更多的是前者对后者的影响。以贾湖类型为代表的裴李岗文化分布在南阳盆地及丹江下游地区,不仅在当地发展为仰韶早期文化,而且还沿着“南襄隘道”与“随枣走廊”南下
中国社科院考古所中国考古网公众号 06-20
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栗媛秋 | 从二里头陶器看中华文明的曙光
栗媛秋 | 从二里头陶器看中华文明的曙光
在中国五千多年文明史的长河中,陶器是最早出现、最为常见的人造器物。在泥与火的艺术中,陶器一路承载着人类的生活记忆,不仅是古人日常生活的见证,更是通过现代科学技术探索中国早期国家形成的重要物质载体。在中
中国社科院考古所中国考古网公众号 06-20
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文献分享|稻田微生物抗性免疫激活的可视化探针及近红外二区荧光成像研究
文献分享|稻田微生物抗性免疫激活的可视化探针及近红外二区荧光成像研究
文献分享|稻田微生物抗性免疫激活的可视化探针及近红外二区荧光成像研究点击上方“蓝字”,发现更多精彩。▉ 导语今天给大家分享一篇发表在期刊 Anal. Chem. 上的文献:A Water-Solubl
iFluorescence公众号 06-20
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地理所赵艳等在Nature Ecology&Evolution发文!
地理所赵艳等在Nature Ecology&Evolution发文!
青藏高原350万年植被动态对气候变化的响应接收日期:2024年12月5日作者:赵艳,秦锋,崔巧玉,李泉,崔亦凡,H. John B. Birks,梁琛,赵文伟,李焕,任维鹤,邓成龙,葛俊逸,孔艳芬,刘
生态学者公众号 06-20
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大连工业大学联合善恩康生物科技(苏州)有限公司在JAFC发表关于Bifidobacterium Longum 300重要成果
大连工业大学联合善恩康生物科技(苏州)有限公司在JAFC发表关于Bifidobacterium Longum 300重要成果
ScienceShare | 科学私享Bifidobacterium Longum 300通过调控“脑肠轴”显著改善D-半乳糖诱导的小鼠认知障碍导 读2025年6月,大连工业大学联合 善恩康生物科技
科学私享公众号 06-20
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IF=14.1!江南大学夏小乐教授团队《Advanced Science》发文!
IF=14.1!江南大学夏小乐教授团队《Advanced Science》发文!
ScienceShare | 科学私享工程细胞色素P450酶和P450还原酶之间的电子转移通量以增强大肠杆菌中血清素的产生导 读2025年5月,江南大学夏小乐教授团队在国际Top期刊《Advance
科学私享公众号 06-20
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IF=8.2!茅台学院FC-X重要成果:机器学习结合GC-FID判别不同类别酱香型白酒
IF=8.2!茅台学院FC-X重要成果:机器学习结合GC-FID判别不同类别酱香型白酒
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科学私享公众号 06-20
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BB.基于多功能标记引物开发通用单步CRISPR检测方法消除不稳定的crRNA输入和PAM依赖性用于细菌感染的即时检测
BB.基于多功能标记引物开发通用单步CRISPR检测方法消除不稳定的crRNA输入和PAM依赖性用于细菌感染的即时检测
全文简介重组酶聚合酶扩增(RPA)与CRISPR/Cas12a的整合在细菌感染的即时检测方面具有巨大潜力,但仍面临诸如不稳定RNA的输入、对PAM的依赖以及多步操作等挑
分析化学方法公众号 06-20
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上海交大黄富强团队Angew:氧硫基质设计突破合金负极循环瓶颈
上海交大黄富强团队Angew:氧硫基质设计突破合金负极循环瓶颈
高能量密度、长循环寿命锂离子电池要求负极材料兼具高比容量与低工作电压。目前商用石墨负极容量有限(~370 mAh g-1),制约了电池的长续航能力。尽管硅基负极理论容量高且已进入工业应用,但仍面临复杂
纳米人公众号 06-20
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破纪录!新国立/厦大,最新Nature!
破纪录!新国立/厦大,最新Nature!
研究背景光子雪崩(Photon Avalanche, PA)是一类发生于镧系离子掺杂体系中的独特非线性光学过程,其核心机制是能量正反馈循环。这一机制赋予材料极为陡峭的激发功率–发光强度响应关系,使得极
纳米人公众号 06-20
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黑龙江大学, Nature Chemistry!!
黑龙江大学, Nature Chemistry!!
研究背景有机半导体是一类能够通过π共轭结构实现电荷传输的材料,因其可溶液加工、柔性可弯曲和低成本等特性,被广泛应用于柔性显示器、可穿戴传感器和光电子器件等领域。与传统的无机半导体材料相比,有机共轭聚合
纳米人公众号 06-20
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OpenAI路线遭质疑!Meta研究员:根本无法构建超级智能
OpenAI路线遭质疑!Meta研究员:根本无法构建超级智能
超级智能(Superintelligence)是处于 AGI 之上、甚至通用能力超过人类的更高维 AI 发展方向。扎克伯格不惜以一亿美金年薪挖角 OpenAI 等竞争对手的动作背后,便暴露了 Meta
学术头条公众号 06-20
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Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Estimating endurance training intensity prescription from the 6-minute stepper test in people with chronic obstructive pulmonary disease - a multicenter cross-sectional study with external validation.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2025.2486875

Background: Home-based pulmonary rehabilitation (PR) can enhance accessibility to PR, but no at-home field exercise test has been validated for individualized endurance training prescriptions.

Research question: What is the accuracy of the six-minute stepper test (6MST) in estimating endurance training intensity as determined during cardiopulmonary exercise testing (CPET)?

Study design and method: This multicenter (N = 3) cross-sectional study included individuals with COPD. Participants performed CPET and two 6MSTs to evaluate the 6MST's ability to estimate endurance training intensity based on CPET-derived heart rate at the first ventilatory threshold (HRvt1), the corresponding power output (Pvt1), and peak power output (Ppeak). Predictive equations were tested for external validity using data from two prior studies.

Results: 105 patients were included (mean age 61 (SD 9) years; mean FEV1 61 (SD 21) %). Predictive equations moderately predicted HRvt1 (r² = 0.38), strongly predicted Pvt1 (r² = 0.63) and very strongly predicted Ppeak (r² = 0.75). External validity was small to moderate for HRvt1 and Pvt1 but was strong for 60% of Ppeak (mean absolute difference: 10W, 95% CI 5 to 10). Passing and Bablok regression confirmed interchangeability for Pvt1 and 60% of Ppeak.

Interpretation: The 6MST offers a reliable method to set initial training intensity when CPET is unavailable.

Clinical trial registration: NCT02842463.

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.07.004

Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA.

Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day.

Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001).

Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

Issue 4 - Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.005

Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms.

Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Influenza's silent toll: A closer look at individuals aged 75 years or older.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2411809
Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
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