文献互助 智能选刊 最新文献
发布求助 登录 注册

Book学术

Book学术logo
高级搜索>>
1.4亿文献 4.8万期刊 平均96.5%应助率
订阅 推荐
高校
化学
纳米材料 高分子材料 能源材料 分离纯化 能源科学
医学
生物医学 生物传感器 蛋白质组学 器官损伤与修复 代谢组学
材料科学
能源材料 光电催化 新型碳制造 碳减排 有色金属
生物学
基因学 微生物学 细胞学 生物多样性 昆虫学
更多
张皓:关于日本发动全面侵华战争的三个本质问题
张皓:关于日本发动全面侵华战争的三个本质问题
作者:张皓来源:“学术研究”微信公众号原文刊载于《学术研究》2025年第5期在长达14年的日本对华侵略战争中,存在日本如何按步骤分阶段发动全面侵华战争、如何构建适应侵华战争的战时体制、如何投入进行全面
中国历史研究院公众号 06-17
×
鲁西奇:中古早期江南的农民——以郭世道父子为中心
鲁西奇:中古早期江南的农民——以郭世道父子为中心
作者:鲁西奇来源:“江海学刊”微信公众号原文刊载于《江海学刊》2023年第5期“农民”,本义是指长期从事农业生产的人。这里的“农业生产”涵义是广义的,包括农耕、游畜牧、捕捞、养殖等生产活动。因此,广义
中国历史研究院公众号 06-17
×
直击电镜最前沿!第十一届电镜大会(6.24-27)重磅开播!
直击电镜最前沿!第十一届电镜大会(6.24-27)重磅开播!
2025年6月24-27日,仪器信息网(www.instrument.com.cn) 与中国电子显微镜学会(对外)(www.china-em.cn)将联合主办“第十一届电子显微学网络会议(iCEM 2
纳米人公众号 06-17
×
东南大学邵起越课题组,AOM!
东南大学邵起越课题组,AOM!
研究背景随着光谱分析技术在无损检测、生物成像等领域的快速发展,对具备宽谱带、长波长近红外(NIR)发光材料的需求日益增长。高效的NIR荧光粉是实现高性能NIR荧光转换型发光二极管(pc-LED)的核心
纳米人公众号 06-17
×
中科大Angew:氧化还原驱动原位形成双金属催化剂
中科大Angew:氧化还原驱动原位形成双金属催化剂
双金属催化剂因其独特的几何与电子结构在多个领域引发广泛关注,但特定双金属体系中离子溶解度或电荷特性导致均匀分散仍具挑战性。鉴于此,中国科学技术大学江俊教授等人提出基于Sn2+/Sn4+价态互变的氧化还
纳米人公众号 06-17
×
上交大/上海有机所,Nature Chemistry!
上交大/上海有机所,Nature Chemistry!
研究背景羰基化合物是有机合成中极为重要的功能基团,因其广泛存在于天然产物、药物分子及材料合成中,被广泛应用于医药化学、材料科学等领域。与传统的羰基转化方法相比,实现羰基C=O键的断裂并将其片段高效整合
纳米人公众号 06-17
×
文献分享|微环境激活型纳米剂用于动脉再狭窄的实时NIR-II监测与靶向治疗
文献分享|微环境激活型纳米剂用于动脉再狭窄的实时NIR-II监测与靶向治疗
文献分享|微环境激活型纳米剂用于动脉再狭窄的实时NIR-II监测与靶向治疗点击上方“蓝字”,发现更多精彩。▉ 导语今天给大家分享一篇发表在期刊 Biomaterials 上的文献:Microenvi
iFluorescence公众号 06-17
×
解码超过1亿年的“昆虫文明”:《细胞》揭开蚂蚁的演化之谜
解码超过1亿年的“昆虫文明”:《细胞》揭开蚂蚁的演化之谜
今天,蚂蚁家族有超过1.5万个现生物种,如果把全球蚂蚁都集中在一起,它们的总重量会超过地球上所有野生鸟类和哺乳动物的总和,广泛分布在除极地之外的所有陆地生态系统中。鲜为人知的是,蚂蚁早在至少1亿年前的
学术经纬公众号 06-17
×
“断供”这种氨基酸,一周减重30%!《自然》子刊:体重狂掉的原因找到了
“断供”这种氨基酸,一周减重30%!《自然》子刊:体重狂掉的原因找到了
近年来,肥胖及其相关代谢疾病成为了全球性健康挑战之一,科学家一直在探索安全、有效的体重管理策略。从饮食干预角度,我们可以通过执行热量限制、间歇性禁食来帮助减重;从药物角度,则有着司美格鲁肽等“明星”减
学术经纬公众号 06-17
×
AC.相互激活的双指数扩增DNA机器增强稳健的CRISPR/Cas12a反馈传播用于超灵敏微小核糖核酸检测
AC.相互激活的双指数扩增DNA机器增强稳健的CRISPR/Cas12a反馈传播用于超灵敏微小核糖核酸检测
全文简介乳腺癌(BC)仍然是一项严峻的全球性健康挑战,因此需要超灵敏的方法来检测生物标志物,比如miR - 155,它是乳腺癌进展过程中的一个关键调控因子。在此,我们提
分析化学方法公众号 06-17
×
南开大学,Nature Chemistry!
南开大学,Nature Chemistry!
均相催化与酶催化群-2:929342001 特别说明:本文由米测技术中心原创撰写,旨在分享相关科研知识。因学识有限,难免有所疏漏和错误,请读者批判性阅读,也恳请大方之家批评指正。原创丨米测MeLab编
催化计公众号 06-17
×
厦门大学/温州大学AM:氟介导界面微环境增强全pH电催化CO2还原
厦门大学/温州大学AM:氟介导界面微环境增强全pH电催化CO2还原
电催化讨论群-1:529627044 在工业电流密度下实现二氧化碳还原反应(CO2RR)高效稳定地转化为增值化学品至关重要,但由于其复杂的气固液界面,这一过程具有挑战性。有鉴于此,厦门大学黄小青教授、
催化计公众号 06-17
×
吴骊珠院士Angew:揭示CO敏感型光催化析氢中Pt物种的作用机制
吴骊珠院士Angew:揭示CO敏感型光催化析氢中Pt物种的作用机制
光催化群-2:927909706 铂(Pt)作为光催化析氢反应中广泛使用的活性组分,其在不同CO浓度环境下的催化行为机制尚不明确。鉴于此,中国科学院理化技术研究所Li-Zhu Wu等以Pt/Nb2O5
催化计公众号 06-17
×
上海有机所JACS展望:金属键合的杂原子自由基用于选择性C-H键官能团化
上海有机所JACS展望:金属键合的杂原子自由基用于选择性C-H键官能团化
均相催化与酶催化群-2:929342001 碳氢键的选择性转化是合成化学的一个前沿研究领域。虽然自由基的高反应性为C-H键功能化提供了另一种有效的途径,但是控制自由基的选择性──特别是在位点选择性氢原
催化计公众号 06-17
×
山东长清仙人台4号墓出土青铜盘的铸造工艺及相关问题
山东长清仙人台4号墓出土青铜盘的铸造工艺及相关问题
摘要:山东长清仙人台4号墓出土的青铜盘,在形制和装饰细节方面具有一定的地域特征。表面观察和X-CT技术分析发现,青铜盘的铸造工艺较为复杂,盘身与盘足、盘耳分铸而成,盘足、盘耳通过铸接、铸焊技术与盘身进
中国社科院考古所中国考古网公众号 06-17
×
绍兴南山遗址出土东周铅锡器的科学分析研究
绍兴南山遗址出土东周铅锡器的科学分析研究
摘要:浙江绍兴南山遗址出土了较多铅锡器,以往在其他东周列国都邑遗址中较少发现。本研究对出土的13件片状、条状、棒状铅锡制品进行了取样分析,发现其中11件材质为铅锡合金,2件为铅块,其中一件铅块含有约2
中国社科院考古所中国考古网公众号 06-17
×
【新书介绍】文明史视域下商周铜礼器组合研究
【新书介绍】文明史视域下商周铜礼器组合研究
基本信息:著者:王祁出版社:中国社会科学出版社出版时间:2025年3月版次:1印刷时间:2025年3月印次:1ISBN:9787522748696内容简介:本书分别讨论了商周时期列鼎列簋制兴起历程、兽
中国社科院考古所中国考古网公众号 06-17
×
小心被Agent偷个人数据!Django缔造者直指“三大致命威胁”:MCP更不安全
小心被Agent偷个人数据!Django缔造者直指“三大致命威胁”:MCP更不安全
AI Agent,似乎已经成为 2025 年最热门的科技名词之一。各大厂商在竞相发布 Agent 相关产品的同时,也在持续向大众输出一种“Agent 可以帮你搞定一切”的观点。然而,抛开当前 Agen
学术头条公众号 06-17
×
The Innovation:自噬调控——解锁神经退行性疾病治疗的新钥匙
The Innovation:自噬调控——解锁神经退行性疾病治疗的新钥匙
1 (增补印刷)神经科学实用图书推荐——《鼠脑应用解剖学》【科学出版社】2 科研工具书《精神疾病啮齿类动物模型及行为学实验》 崔东红/徐林著 3 重磅新书推荐 |《奈特神经病学》(第3版)临床实践中神
brainnews公众号 06-17
×
文章速递|《地球科学》中文版2025年第5期目录
文章速递|《地球科学》中文版2025年第5期目录
西藏定日地震专栏特邀主编 徐锡伟 任俊杰2025年西藏定日MW7.1级地震:一次典型的正断层型地震◼ 徐锡伟,任俊杰◼ 据中国地震台网中心测定,2025年1月7日在西藏定日县发生破坏性地震,简称“
地球科学编辑部公众号 06-17
×
Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Estimating endurance training intensity prescription from the 6-minute stepper test in people with chronic obstructive pulmonary disease - a multicenter cross-sectional study with external validation.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2025.2486875

Background: Home-based pulmonary rehabilitation (PR) can enhance accessibility to PR, but no at-home field exercise test has been validated for individualized endurance training prescriptions.

Research question: What is the accuracy of the six-minute stepper test (6MST) in estimating endurance training intensity as determined during cardiopulmonary exercise testing (CPET)?

Study design and method: This multicenter (N = 3) cross-sectional study included individuals with COPD. Participants performed CPET and two 6MSTs to evaluate the 6MST's ability to estimate endurance training intensity based on CPET-derived heart rate at the first ventilatory threshold (HRvt1), the corresponding power output (Pvt1), and peak power output (Ppeak). Predictive equations were tested for external validity using data from two prior studies.

Results: 105 patients were included (mean age 61 (SD 9) years; mean FEV1 61 (SD 21) %). Predictive equations moderately predicted HRvt1 (r² = 0.38), strongly predicted Pvt1 (r² = 0.63) and very strongly predicted Ppeak (r² = 0.75). External validity was small to moderate for HRvt1 and Pvt1 but was strong for 60% of Ppeak (mean absolute difference: 10W, 95% CI 5 to 10). Passing and Bablok regression confirmed interchangeability for Pvt1 and 60% of Ppeak.

Interpretation: The 6MST offers a reliable method to set initial training intensity when CPET is unavailable.

Clinical trial registration: NCT02842463.

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.07.004

Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA.

Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day.

Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001).

Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

Issue 4 - Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.005

Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms.

Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Influenza's silent toll: A closer look at individuals aged 75 years or older.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2411809
Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1
分享赚积分
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱