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窦贤康:破解人才“帽子”异化使用,推动科研项目回归学术本位
窦贤康:破解人才“帽子”异化使用,推动科研项目回归学术本位
【求是网】切实提升基础研究和原始创新能力窦贤康我们党和国家历来重视基础研究工作。党的十八大以来,以习近平同志为核心的党中央把提升基础研究能力摆在更加突出的位置。习近平总书记就
高分子科技公众号 04-24
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普涨!最高仅8.6!最新中科院2区食品期刊即时IF(25.4.24)
普涨!最高仅8.6!最新中科院2区食品期刊即时IF(25.4.24)
ScienceShare | 科学私享27本中科院2区食品英文期刊即时IF出炉(2025.4.24)导 读为了便于大家及时掌握食品相关领域中科院一区SCI期刊的影响因子变化,《科学私享》根据官方数据
科学私享公众号 04-24
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最新!国自然面上项目同行评议与项目遴选标准!
最新!国自然面上项目同行评议与项目遴选标准!
2024年,国自然医学科学部在中国科学基金发表了一篇题为《国家自然科学基金面上项目的遴选标准及其规范化探讨》的文章,其中详细讨论了基金项目中同行评议意见(文字评述和评议结论)与遴选项目关系,时代学者摘
科学私享公众号 04-24
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即时IF=9.7!中国农大姜微波教授团队食品顶刊发文!
即时IF=9.7!中国农大姜微波教授团队食品顶刊发文!
ScienceShare | 科学私享丁香精油的封装策略对其食品保鲜应用中递送效果的增效作用导 读2025年4月,中国农业大学姜微波教授团队在国际食品Top期刊《Food Chemistry》(Q1
科学私享公众号 04-24
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Nat. Commun.:猕猴大脑如何“导航”手的运动?自动化所研究发现类似“GPS”的神经编码机制
Nat. Commun.:猕猴大脑如何“导航”手的运动?自动化所研究发现类似“GPS”的神经编码机制
1 (增补印刷)神经科学实用图书推荐——《鼠脑应用解剖学》【科学出版社】2 科研工具书《精神疾病啮齿类动物模型及行为学实验》 崔东红/徐林著 3 重磅新书推荐 |《奈特神经病学》(第3版)中国科学院自
brainnews公众号 04-24
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程时锋团队一年前预印版,终发Nature!
程时锋团队一年前预印版,终发Nature!
2024年6月14日,溪远讲植物科学公众号推送了:详情点阅程时锋团队领衔:基于大型GWAS分析重新探讨孟德尔豌豆性状背后的基因该文为预印本,未经同行评议。同时改论文于2024年6月11日投稿到Natu
溪远讲植物科学公众号 04-24
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文献分享|多功能单分子荧光探针对肝纤维化的双色可视化及治疗药物的多维评估
文献分享|多功能单分子荧光探针对肝纤维化的双色可视化及治疗药物的多维评估
文献分享|多功能单分子荧光探针对肝纤维化的双色可视化及治疗药物的多维评估点击上方“蓝字”,发现更多精彩。▉ 导语今天给大家分享一篇发表在期刊 ACS Sens. 上的文献:Dual-Color Vis
iFluorescence公众号 04-24
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哈勃入轨35周年
哈勃入轨35周年
2025年,为纪念NASA/ESA哈勃空间望远镜在地球轨道上运行35周年,一组全新的宇宙精彩图像今天正式发布。这些图像从火星一直延伸到星辰的诞生与死亡,再到我们邻近的壮观星系,展示了宇宙的瑰丽与神秘。
NASA爱好者公众号 04-24
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沙武田:回鹘风格洞窟与敦煌宋夏石窟分期
沙武田:回鹘风格洞窟与敦煌宋夏石窟分期
作者:沙武田来源:“甘肃社会科学”微信公众号原文刊载于《甘肃社会科学》2025年第1期柏孜克里克第16窟供养人像(图源:《中国新疆壁画艺术6》第241页)敦煌晚期石窟的分期是目前敦煌学研究的一个热点问
中国历史研究院公众号 04-24
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过勇:全面把握新时代廉洁文化建设的总体要求
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作者:过勇来源:《人民日报》(2025年1月17日 第9版)习近平总书记指出:“要加强新时代廉洁文化建设。深入开展党性党风党纪教育,传承党的光荣传统和优良作风,激发共产党员崇高理想追求,把以权谋私、贪
中国历史研究院公众号 04-24
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Science正刊!植物响应干旱的生理机制
Science正刊!植物响应干旱的生理机制
The physiology of plant responses to drought植物对干旱响应的生理机制干旱是农业生产中最具破坏性的自然灾害,每年干旱导致的作物减产量超过所有病虫害的总和。随着
生态学者公众号 04-24
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给水排水 | 绿色水厂新标杆:再生水回用+光伏发电,珠海案例给出答案
给水排水 | 绿色水厂新标杆:再生水回用+光伏发电,珠海案例给出答案
为解决珠海高新区土地资源紧张的问题,珠海市北区水质净化厂二期采用全地埋形式建设,处理能力15万 m³/d,并将上部空间打造为集办公、交通、体育、休闲等公共设施于一体的综合利用空间。污水核心处理工艺为改
给水排水公众号 04-24
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CJPS 封面报道| 东华大学何勇教授课题组研究论文:探究溴代芳烃底物对EDOT直接芳基化的影响旨在制备高分子量共轭聚合物
CJPS 封面报道| 东华大学何勇教授课题组研究论文:探究溴代芳烃底物对EDOT直接芳基化的影响旨在制备高分子量共轭聚合物
封面说明共轭聚合物因其优异性能广泛应用于各类有机电子器件。图示两机械臂执行直接芳基化聚合的关键步骤:"金属协同去质子化"与"还原消除",通过精准调控实现高效合成。 第一作者:裴熙林,杨权通信联系人:何
中国高分子公众号 04-24
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【ACS Nano】通过巨噬细胞耗竭策略提升mRNA-LNPs的生物分布和表达效率
【ACS Nano】通过巨噬细胞耗竭策略提升mRNA-LNPs的生物分布和表达效率
迄今为止,大多数已报道的LNP制剂在全身给药时倾向于将mRNA递送至肝脏。因此,该技术已被广泛应用于肝脏疾病相关靶蛋白表达的研究,包括体内肝基因编辑。然而,这些循环中的LNPs会被吞噬细胞清除或错误导
NanoBioMaterials公众号 04-24
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25年4月23日文献情报(10篇)
25年4月23日文献情报(10篇)
25年4月23日文献情报点击阅读原文进入数据库检索:以文章编号N250423为检索词可查询到的文章数量: 10。长按文章二维码识别后可跳转至文章所在期刊网页,关注天然有机质文献简报小程序追踪最新100
天然有机质研究情报公众号 04-24
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中国农科院作科所博士后一作在植物科学顶级期刊(IF=17.1)发表研究成果!
中国农科院作科所博士后一作在植物科学顶级期刊(IF=17.1)发表研究成果!
2025年4月22日,中国农业科学院作物科学研究所李新海研究员团队在Molecular Plant 发表了题为“Natural variations in the promoter of ZmDeSI
溪远讲植物科学公众号 04-24
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Adam获时间检验奖!清华揭示保辛动力学本质,提出全新RAD优化器
Adam获时间检验奖!清华揭示保辛动力学本质,提出全新RAD优化器
买科研服务(代计算、代测试、超算机时),送老李校长“科研理工男士情感课”第一性原理计算解决50年悬而未决难题:半导体中铜为何扩散更快?Ab initio及第一性原理入门参考书介绍《海贼王》告诉你,做科
计算材料学公众号 04-24
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(纯计算)山东师范大学任俊峰团队Phys. Rev. B: 四方交错磁/铁磁单层M2SiCX2中的层锁多谷霍尔效应
(纯计算)山东师范大学任俊峰团队Phys. Rev. B: 四方交错磁/铁磁单层M2SiCX2中的层锁多谷霍尔效应
买科研服务(代计算、代测试、超算机时),送老李校长“科研理工男士情感课”第一性原理计算解决50年悬而未决难题:半导体中铜为何扩散更快?Ab initio及第一性原理入门参考书介绍《海贼王》告诉你,做科
计算材料学公众号 04-24
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大尺寸批量化石墨板上CVD SiC生长机理研究
大尺寸批量化石墨板上CVD SiC生长机理研究
买科研服务(代计算、代测试、超算机时),送老李校长“科研理工男士情感课”第一性原理计算解决50年悬而未决难题:半导体中铜为何扩散更快?Ab initio及第一性原理入门参考书介绍《海贼王》告诉你,做科
计算材料学公众号 04-24
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原子制造之“局域”遍历性
原子制造之“局域”遍历性
买科研服务(代计算、代测试、超算机时),送老李校长“科研理工男士情感课”第一性原理计算解决50年悬而未决难题:半导体中铜为何扩散更快?Ab initio及第一性原理入门参考书介绍《海贼王》告诉你,做科
计算材料学公众号 04-24
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Defective exercise-related expiratory muscle recruitment in patients with PHOX2B mutations: A clue to neural determinants of the congenital central hypoventilation syndrome.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.01.005

Introduction and objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response. Whether this can be extrapolated to human CCHS is unknown and represents the objective of this study.

Materials and methods: Thirteen adult CCHS patients and 13 healthy participants performed an incremental symptom-limited cycle cardiopulmonary exercise test. Responses were analyzed using guideline approaches (ventilation V'E, tidal volume VT, breathing frequency, oxygen consumption, carbon dioxide production) complemented by a breathing pattern analysis (i.e. expiratory and inspiratory reserve volume, ERV and IRV).

Results: A ventilatory response occurred in both study groups, as follows: V'E and VT increased in CCHS patients until 40 W and then decreased, which was not observed in the healthy participants (p<0.001). In the latter, exercise-related ERV and IRV decreases attested to concomitant expiratory and inspiratory recruitment. In the CCHS patients, inspiratory recruitment occurred but there was no evidence of expiratory recruitment (absence of any ERV decrease, p<0.001).

Conclusions: Assuming a similar organization of respiratory rhythmogenesis in humans and rodents, the lack of exercise-related expiratory recruitment observed in our CCHS patients is compatible with a PHOX2B-related defect of a neural structure that would be analogous to the rodents' RTN. Provided corroboration, ERV recruitment could serve as a physiological outcome in studies aiming at correcting breathing control in CCHS.

Development and evaluation of spirometry reference equations at high altitude.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2433862

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure. All individuals underwent pre- and post-bronchodilator measurement. We used the Lambda-Mu-Sigma (LMS) method to establish reference equations for various spirometry parameters. We assessed model fit using mean absolute error (MAE), mean absolute percentage error (MAPE), and residual values (standard deviation), relative to established benchmarks such as GLI, ECSC, and NHANES III, to evaluate the applicability of our equations to high-altitude residents. Between June 2015 and August 2016, 3174 healthy subjects were included. The reference equations utilise age and height as independent variables, with improved accuracy achieved through spline functions. Our spirometry reference equations demonstrate minimal MAE, MAPE, and residual values (standard deviation) for most of the analysed spirometry parameters, stratified by gender. Our spirometry reference equations are more applicable to residents of high-altitude regions.

Efficacy and safety of high-flow nasal cannula therapy in elderly patients with acute respiratory failure. Authors´reply.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2444727
Asbestos-related diseases in Africa: sentinel cases of mesothelioma and asbestosis from DR Congo.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2449268
Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2023.07.004

Introduction: Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA.

Materials and methods: We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day.

Results: In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001).

Conclusions: In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.

Issue 4 - Impact of air pollution on COVID-19 mortality and morbidity: An epidemiological and mechanistic review.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.005

Air pollution is a major global environment and health concern. Recent studies have suggested an association between air pollution and COVID-19 mortality and morbidity. In this context, a close association between increased levels of air pollutants such as particulate matter ≤2.5 to 10 µM, ozone and nitrogen dioxide and SARS-CoV-2 infection, hospital admissions and mortality due to COVID 19 has been reported. Air pollutants can make individuals more susceptible to SARS-CoV-2 infection by inducing the expression of proteins such as angiotensin converting enzyme (ACE)2 and transmembrane protease, serine 2 (TMPRSS2) that are required for viral entry into the host cell, while causing impairment in the host defence system by damaging the epithelial barrier, muco-ciliary clearance, inhibiting the antiviral response and causing immune dysregulation. The aim of this review is to report the epidemiological evidence on impact of air pollutants on COVID 19 in an up-to-date manner, as well as to provide insights on in vivo and in vitro mechanisms.

Rehabilitation and physiotherapists in the critical care medicine.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1016/j.pulmoe.2024.04.006
Predicting maximum oxygen uptake using the six-minute walk distance in adults: What is the best curve fit estimation?
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2413778
Influenza's silent toll: A closer look at individuals aged 75 years or older.
IF 10.4 2区 医学 Q1 RESPIRATORY SYSTEM Pub Date : 2025-12-31 DOI: 10.1080/25310429.2024.2411809
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