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The Innovation | 推动肿瘤精准治疗:深入了解肿瘤微环境和免疫治疗疗效的相互关系
The Innovation | 推动肿瘤精准治疗:深入了解肿瘤微环境和免疫治疗疗效的相互关系
更好地了解肿瘤微环境对于阐明肿瘤的病因和制定更有效的治疗策略至关重要。导 读本文探讨了肿瘤微环境的复杂成分及其对免疫治疗的影响。本文聚焦近期北京大学肿瘤医院消化内科沈琳教授团队的两项研究成果,包括发现
TheInnovation创新公众号 4小时前
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Cell Rep | 中国医科大学曹流团队揭示CHK2-USP7轴的磷酸化-去泛素化正反馈环稳定p53并维持细胞稳态的机制
Cell Rep | 中国医科大学曹流团队揭示CHK2-USP7轴的磷酸化-去泛素化正反馈环稳定p53并维持细胞稳态的机制
p53是一个众所周知的肿瘤抑制蛋白,在DNA损伤和氧化应激条件下,p53调节多种信号通路并维持细胞稳态。尽管USP7已被证明通过去泛素化促进p53的稳定性,但USP7-p53激活机制仍不清楚。2024
Immunity Advances公众号 4小时前
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研究前沿:微机电系统MEMS-关键器件材料 | Nature Electronics
研究前沿:微机电系统MEMS-关键器件材料 | Nature Electronics
具有集成电子传感和驱动的有源微机电系统microelectromechanical systems (MEMS) ,可提供力、加速度和生物分析物的快速且灵敏测量。集成在微机电系统MEMS悬臂梁上的应变
今日新材料公众号 4小时前
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Neuron:浙江大学段树民/虞燕琴团队揭示大脑调控攻击行为性别差异性的神经环路机制
Neuron:浙江大学段树民/虞燕琴团队揭示大脑调控攻击行为性别差异性的神经环路机制
1 (增补印刷)神经科学实用图书推荐——《鼠脑应用解剖学》【科学出版社】2 科研工具书《精神疾病啮齿类动物模型及行为学实验》 崔东红/徐林著 3 重磅新书推荐 |《奈特神经病学》(第3版)2024年7
brainnews公众号 4小时前
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Nat Commun:浙中医陈忠团队发现减轻恐惧导致的心理疾病的新靶点
Nat Commun:浙中医陈忠团队发现减轻恐惧导致的心理疾病的新靶点
1 (增补印刷)神经科学实用图书推荐——《鼠脑应用解剖学》【科学出版社】2 科研工具书《精神疾病啮齿类动物模型及行为学实验》 崔东红/徐林著 3 重磅新书推荐 |《奈特神经病学》(第3版)来源:iNa
brainnews公众号 4小时前
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研究进展:脂质体纳米材料 | Nature Chemistry
研究进展:脂质体纳米材料 | Nature Chemistry
脂质体和脂质纳米颗粒等软物质纳米组装体,以外部刺激和位点特异性方式,实现药物递送和释放。这种组件,目前在结构上过于简单,包括球形胶囊或脂质簇。考虑到形式和功能是交织在一起的,这种单一构造限制了更复杂属
今日新材料公众号 4小时前
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研究前沿:太赫兹成像/2H-NbSe2 | Nature Physics
研究前沿:太赫兹成像/2H-NbSe2 | Nature Physics
电荷密度波Charge density waves是材料电子密度的波状调制方式,显示了集体振幅和相位动力学。然而,原子杂质的相互作用,导致了电荷有序相强烈的空间不均匀性。这种缺陷引起了电荷调制的相位激
今日新材料公众号 4小时前
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Nat Commun:贾晓轩等揭示视觉刺激对大规模单神经元功能网络拓扑结构的影响
Nat Commun:贾晓轩等揭示视觉刺激对大规模单神经元功能网络拓扑结构的影响
1 (增补印刷)神经科学实用图书推荐——《鼠脑应用解剖学》【科学出版社】2 科研工具书《精神疾病啮齿类动物模型及行为学实验》 崔东红/徐林著 3 重磅新书推荐 |《奈特神经病学》(第3版)来源:清华I
brainnews公众号 4小时前
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【Nat.Rev.Methods Primers】用于纳米医疗保健的纳米酶-南京大学魏辉教授团队,IF=50.1
【Nat.Rev.Methods Primers】用于纳米医疗保健的纳米酶-南京大学魏辉教授团队,IF=50.1
Nanozymes for nanohealthcareNature Reviews Methods Primers ( IF 50.1 ) Pub Date : 2024-05-30DOI: 10.
纳米材料催化公众号 4小时前
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7.17 脑科学日报 | 心血管健康或是未来失智症发病率的最大风险因素
7.17 脑科学日报 | 心血管健康或是未来失智症发病率的最大风险因素
第2143期 脑科学日报2024年7月17日科 学 时 讯1,Current Biology:失眠抑郁?陆军军医大胡志安/任栓成与吉林大学赵华团队揭示睡眠障碍新机制来源:丁香学术LHb 神经
brainnews公众号 4小时前
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研究进展:药物递送-细胞疗法 | Nature Chemistry
研究进展:药物递送-细胞疗法 | Nature Chemistry
细胞疗法Cell therapies,如免疫细胞疗法和干细胞疗法,正在临床和前临床阶段,用以探索治疗疑难杂症。然而,将药效活性细胞转化为临床细胞疗法,仍面临许多挑战。设计微纳和宏观尺度的药物递送系统,
今日新材料公众号 4小时前
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研究进展:胶原蛋白 | Nature Chemistry
研究进展:胶原蛋白 | Nature Chemistry
最丰富的天然胶原形成了异源三聚体三螺旋。目前已经发现了胶原蛋白异源三聚体的合成模拟过程,折叠缓慢,甚至与已经很慢的同源三聚体螺旋相比也是如此。这些延长的折叠速率,还不清楚。近日,美国 莱斯大学(Ric
今日新材料公众号 4小时前
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Nature | 衰老的胶质细胞如何链接线粒体功能障碍和脂质积累
Nature | 衰老的胶质细胞如何链接线粒体功能障碍和脂质积累
衰老是一种细胞状态,与多种哺乳动物的衰老和年龄相关疾病密切相关。急性衰老细胞在促进伤口愈合和预防肿瘤形成方面具有积极作用,但它们也具有促炎性,从而长期加剧组织衰退。尽管衰老细胞是抗衰老治疗的主要目标,
Immunity Advances公众号 4小时前
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Biol Res | 高脂饮食会影响大脑,增加焦虑、抑郁风险!
Biol Res | 高脂饮食会影响大脑,增加焦虑、抑郁风险!
肥胖与高脂饮食(HFD)的摄入密切相关,并且在现代城市社会中与焦虑的发生率显著上升。近年来,研究表明,肠道菌群-脑轴信号传导,包括脑内5-羟色胺(5-HT)系统在HFD与焦虑之间的关系中起着关键作用,
Immunity Advances公众号 4小时前
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研究前沿:等离子体激元材料 | Nature Physics
研究前沿:等离子体激元材料 | Nature Physics
最近兴起的等离子体激元材料plasmonic materials,可用于太阳能-化学能量转换,并将重点研究了金属-分子界面的电荷和能量流相关机制。理解这些效应及其在吸附分子的等离子体激元激发中的作用之
今日新材料公众号 4小时前
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反位结构构筑稳定的钠离子电池正极材料并调控阴/阳离子的氧化还原研究 | 进展
反位结构构筑稳定的钠离子电池正极材料并调控阴/阳离子的氧化还原研究 | 进展
钠离子电池能够补充锂离子电池的市场应用,并在一定程度上缓解锂资源短缺的问题。正极材料性能的上限决定了钠离子电池电化学性能的上限,其中具有阴离子氧化还原活性的富Mn层状氧化物因其高容量而倍受关注。然而,
中科院物理所公众号 07-16
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优秀!硕士生以第一作者身份在一区Top期刊(IF=12.2)上发表研究成果
优秀!硕士生以第一作者身份在一区Top期刊(IF=12.2)上发表研究成果
近日,中国农业科学院植物保护研究所中美生物防治实验室在《Journal of Hazardous Materials》(JCR 1区,IF=12.2)上在线发表了题为“Detoxification
植物研究进展公众号 07-16
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山东农业大学博士后以第一作者身份在国际知名期刊(IF=8.2)上发表研究成果
山东农业大学博士后以第一作者身份在国际知名期刊(IF=8.2)上发表研究成果
近日,山东农业大学资源与环境学院王军教授课题组在《Science of the Total Environment》发表了题为“Environmental efficacy of polyethyl
植物研究进展公众号 07-16
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副研究员以第一作者身份在一区Top期刊(IF=12.2)上发表研究成果,在水稻镉累积的分子调控研究取得进展
副研究员以第一作者身份在一区Top期刊(IF=12.2)上发表研究成果,在水稻镉累积的分子调控研究取得进展
水稻是最主要的粮食作物,其品质和产量易受土壤重金属污染的影响。镉是污染土壤环境最主要的重金属,严重威胁我国的耕地安全和粮食安全。作为一种致癌物质,镉可以通过“镉大米”在人体内累积导致人骨骼变脆和肾功能
植物研究进展公众号 07-16
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重磅!2024植物科学领域连发Nature 原来是用了这些热点技能!
重磅!2024植物科学领域连发Nature 原来是用了这些热点技能!
近年来,深度学习领域的迅速进步对蛋白质设计产生了显著影响。最近,深度学习方法在蛋白质结构预测方面取得了重大突破,使我们能够得到数百万种蛋白质的高质量模型。结合用于生成建模和序列分析的新型架构,这些方法
植物研究进展公众号 07-16
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TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation.
IF 3.6 4区 医学 Q1 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-12-31 DOI: 10.1080/15384047.2024.2325126

Ovarian cancer (OC) is a form of gynecological malignancy that is associated with worse patient outcomes than any other cancer of the female reproductive tract. Topoisomerase II α (TOP2A) is commonly regarded as an oncogene that is associated with malignant disease progression in a variety of cancers, its mechanistic functions in OC have yet to be firmly established. We explored the role of TOP2A in OC through online databases, clinical samples, in vitro and in vivo experiments. And initial analyses of public databases revealed high OC-related TOP2A expression in patient samples that was related to poorer prognosis. This was confirmed by clinical samples in which TOP2A expression was elevated in OC relative to healthy tissue. Kaplan-Meier analyses further suggested that higher TOP2A expression levels were correlated with worse prognosis in OC patients. In vitro, TOP2A knockdown resulted in the inhibition of OC cell proliferation, with cells entering G1 phase arrest and undergoing consequent apoptotic death. In rescue assays, TOP2A was confirmed to regulate cell proliferation and cell cycle through AKT/mTOR pathway activity. Mouse model experiments further affirmed the key role that TOP2A plays as a driver of OC cell proliferation. These data provide strong evidence supporting TOP2A as an oncogenic mediator and prognostic biomarker related to OC progression and poor outcomes. At the mechanistic level, TOP2A can control tumor cell growth via AKT/mTOR pathway modulation. These preliminary results provide a foundation for future research seeking to explore the utility of TOP2A inhibitor-based combination treatment regimens in platinum-resistant recurrent OC patients.

A Medical Education Research Library: key research topics and associated experts.
IF 4.6 2区 医学 Q1 Social Sciences Pub Date : 2024-12-31 DOI: 10.1080/10872981.2024.2302233

When clinician-educators and medical education researchers use and discuss medical education research, they can advance innovation in medical education as well as improve its quality. To facilitate the use and discussions of medical education research, we created a prefatory visual representation of key medical education research topics and associated experts. We conducted one-on-one virtual interviews with medical education journal editorial board members to identify what they perceived as key medical education research topics as well as who they associated, as experts, with each of the identified topics. We used content analysis to create categories representing key topics and noted occurrences of named experts. Twenty-one editorial board members, representing nine of the top medical education journals, participated. From the data we created a figure entitled, Medical Education Research Library. The library includes 13 research topics, with assessment as the most prevalent. It also notes recognized experts, including van der Vleuten, ten Cate, and Norman. The key medical education research topics identified and included in the library align with what others have identified as trends in the literature. Selected topics, including workplace-based learning, equity, diversity, and inclusion, physician wellbeing and burnout, and social accountability, are emerging. Once transformed into an open educational resource, clinician-educators and medical education researchers can use and contribute to the functional library. Such continuous expansion will generate better awareness and recognition of diverse perspectives. The functional library will help to innovate and improve the quality of medical education through evidence-informed practices and scholarship.

Analyzing diversity, equity, and inclusion content on dermatology fellowship program websites.
IF 4.6 2区 医学 Q1 Social Sciences Pub Date : 2024-12-31 DOI: 10.1080/10872981.2024.2347762

Diversity, Equity, and Inclusion (DEI) initiatives have garnered increasing attention within medical education as there have been increased efforts to diversify the physician workforce among medical students, residents, fellows, and attendings. One way in which programs can improve their DEI initiatives and attract a more diverse pool of applicants is through DEI content on their graduate medical education websites. Prior studies characterizing the content and prevalence of DEI material on residency webpages have shown that dermatology residencies have relatively low levels of DEI content on their websites in which almost ¾ of all programs having no DEI content. Little is known, however, if similar findings are to be expected for the three main dermatology subspecialty fellowship program webpages: Dermatopathology, Pediatric Dermatology, and Micrographic Surgery and Dermatology Oncology. Fellowship programs were identified using the Accreditation Council for Graduate Medical Education's online database of fellowship programs. Programs were evaluated on a standardized scoring system for five equally weighted criteria: fellowship-specific DEI webpage, DEI commitment statement, DEI initiatives (summer research opportunities for under-represented minorities, DEI council, etc.), link to the institution's DEI homepage, and information about bias training. The mean score among all programs was 12.5. Pediatric dermatology ranked the highest among all specialties, while Mohs ranked the lowest. A link to the institution's DEI homepage was the most prevalent factor accounting for 42.1% of all programs collected, whereas information about bias training and fellowship-associated DEI webpage were the least prevalent. The results of this study reveal an overall lack of DEI content across all dermatology subspecialties' webpages and represent an actionable area of improvement for fellowship directors to increase their DEI efforts to attract a diverse pool of applicants to their program.

Utility of cell-based vaccines as cancer therapy: Systematic review and meta-analysis.
IF 4.8 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-12-31 DOI: 10.1080/21645515.2024.2323256

Cell-based therapeutic cancer vaccines use autologous patient-derived tumor cells, allogeneic cancer cell lines or autologous antigen presenting cells to mimic the natural immune process and stimulate an adaptive immune response against tumor antigens. The primary objective of this study is to perform a systematic literature review with an embedded meta-analysis of all published Phase 2 and 3 clinical trials of cell-based cancer vaccines in human subjects. The secondary objective of this study is to review trials demonstrating biological activity of cell-based cancer vaccines that could uncover additional hypotheses, which could be used in the design of future studies. We performed the systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The final review included 36 studies - 16 single-arm studies, and 20 controlled trials. Our systematic review of the existing literature revealed largely negative trials and our meta-analysis did not show evidence of clinical benefit from cell-based cancer-vaccines. However, as we looked beyond the stringent inclusion criteria of our systematic review, we identified significant examples of biological activity of cell-based cancer vaccines that are worth highlighting. In conclusion, the existing literature on cell-based cancer vaccines is highly variable in terms of cancer type, vaccine therapies and the clinical setting with no overall statistically significant clinical benefit, but there are individual successes that represent the promise of this approach. As cell-based vaccine technology continues to evolve, future studies can perhaps fulfill the potential that this exciting field of anti-cancer therapy holds.

Hospitalization burden associated with anus and penis neoplasm in Spain (2016-2020).
IF 4.8 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-12-31 DOI: 10.1080/21645515.2024.2334001

In 2020, there were approximately 50,865 anal cancer cases and 36,068 penile cancer cases worldwide. HPV is considered the main causal agent for the development of anal cancer and one of the causal agents responsible for the development of penile cancer. The aim of this epidemiological, descriptive, retrospective study was to describe the burden of hospitalization associated with anal neoplasms in men and women and with penis neoplasms in men in Spain from 2016 to 2020. The National Hospital Data Surveillance System of the Ministry of Health, Conjunto Mínimo Básico de Datos, provided the discharge information used in this observational retrospective analysis. A total of 3,542 hospitalizations due to anal cancer and 4,270 hospitalizations due to penile cancer were found; For anal cancer, 57.4% of the hospitalizations occurred in men, and these hospitalizations were also associated with significantly younger mean age, longer hospital stays and greater costs than those in women. HIV was diagnosed in 11.19% of the patients with anal cancer and 1.74% of the patients with penile cancer. The hospitalization rate was 2.07 for men and 1.45 for women per 100,000 in anal cancer and of 4.38 per 100,000 men in penile cancer. The mortality rate was 0.21 for men and 0.12 for women per 100,000 in anal cancer and 0.31 per 100.000 men in penile cancer and the case-fatality rate was 10.07% in men and 8,26% in women for anal cancer and 7.04% in penile cancer. HIV diagnosis significantly increased the cost of hospitalization. For all the studied diagnoses, the median length of hospital stays and hospitalization cost increased with age. Our study offers relevant data on the burden of hospitalization for anal and penile cancer in Spain. This information can be useful for future assessment on the impact of preventive measures, such as screening or vaccination in Spain.

Knowledge mapping of immunotherapy for breast cancer: A bibliometric analysis from 2013 to 2022.
IF 4.8 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-12-31 DOI: 10.1080/21645515.2024.2335728

Breast cancer is the leading cause of cancer-related death among women globally. Immunotherapy has emerged as a major milestone in contemporary oncology. This study aims to conduct a bibliometric analysis in the field of immunotherapy for breast cancer, providing a comprehensive overview of the current research status, identifying trends and hotspots in research topics. We searched and retrieved data from the Web of Science Core Collection, and performed a bibliometric analysis of publications on immunotherapy for breast cancer from 2013 to 2022. Current status and hotspots were evaluated by co-occurrence analysis using VOSviewer. Evolution and bursts of knowledge base were assessed by co-citation analysis using CiteSpace. Thematic evolution by bibliometrix package was used to discover keywords trends. The attribution and collaboration of countries/regions, institutions and authors were also explored. A total of 7,975 publications were included. In co-occurrence analysis of keywords, 6 major clusters were revealed: tumor microenvironment, prognosis biomarker, immune checkpoints, novel drug delivery methods, immune cells and therapeutic approaches. The top three most frequently mentioned keywords were tumor microenvironment, triple-negative breast cancer, and programmed cell death ligand 1. The most productive country, institution and author were the USA (2926 publications), the University of Texas MD Anderson Cancer Center (219 publications), and Sherene Loi (28 publications), respectively. There has been a rapid growth in studies on immunotherapy for breast cancer worldwide. This research area has gained increasing attention from different countries and institutions. With the rising incidence of breast cancer, immunotherapy represents a research field of significant clinical value and potential.

Interactive effects of atmospheric oxidising pollutants and heat waves on the risk of residential mortality.
IF 2.6 3区 医学 Q1 Medicine Pub Date : 2024-12-31 DOI: 10.1080/16549716.2024.2313340

Background: The impact of heat waves and atmospheric oxidising pollutants on residential mortality within the framework of global climate change has become increasingly important.

Objective: In this research, the interactive effects of heat waves and oxidising pollutants on the risk of residential mortality in Fuzhou were examined. Methods We collected environmental, meteorological, and residential mortality data in Fuzhou from 1 January 2016, to 31 December 2021. We then applied a generalised additive model, distributed lagged nonlinear model, and bivariate three-dimensional model to investigate the effects and interactions of various atmospheric oxidising pollutants and heat waves on the risk of residential mortality.

Results: Atmospheric oxidising pollutants increased the risk of residential mortality at lower concentrations, and O3 and Ox were positively associated with a maximum risk of 2.19% (95% CI: 0.74-3.66) and 1.29% (95% CI: 0.51-2.08). The risk of residential mortality increased with increasing temperature, with a strong and long-lasting effect and a maximum cumulative lagged effect of 1.11% (95% CI: 1.01, 1.23). Furthermore, an interaction between atmospheric oxidising pollutants and heat waves may have occurred: the larger effects in the longest cumulative lag time on residential mortality per 10 µg/m3 increase in O3, NO2 and Ox during heat waves compared to non-heat waves were [-3.81% (95% CI: -14.82, 8.63)]; [-0.45% (95% CI: -2.67, 1.81)]; [67.90% (95% CI: 11.55, 152.71)]; 16.37% (95% CI: 2.43, 32.20)]; [-3.00% (95% CI: -20.80, 18.79)]; [-0.30% (95% CI: -3.53, 3.04)]. The risk on heat wave days was significantly higher than that on non-heat wave days and higher than the separate effects of oxidising pollutants and heat waves.

Conclusions: Overall, we found some evidence suggesting that heat waves increase the impact of oxidising atmospheric pollutants on residential mortality to some extent.

Immune regulation and the tumor microenvironment in anti-PD-1/PDL-1 and anti-CTLA-4 therapies for cancer immune evasion: A bibliometric analysis.
IF 4.8 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-12-31 DOI: 10.1080/21645515.2024.2318815

This study aims to conduct a bibliometric analysis, employing visualization tools to examine literature pertaining to tumor immune evasion related to anti-CTLA-4 and anti-PD-1/PD-L1 therapy from 1999 to 2022. A special emphasis is placed on the interplay between tumor microenvironment, signaling pathways, immune cells and immune evasion, with data sourced from the Web of Science core collection (WoSCC). Advanced tools, including VOSviewer, Citespace, and Scimago Graphica, were utilized to analyze various parameters, such as co-authorship/co-citation patterns, regional contributions, journal preferences, keyword co-occurrences, and significant citation bursts. Out of 4778 publications reviewed, there was a marked increase in research focusing on immune evasion, with bladder cancer being notably prominent. Geographically, China, the USA, and Japan were the leading contributors. Prestigious institutions like MD Anderson Cancer Center, Harvard Medical School, Fudan University, and Sun Yat Sen University emerged as major players. Renowned journals in this domain included Frontiers in Immunology, Cancers, and Frontiers in Oncology. Ehen LP and Wang W were identified as prolific authors on this topic, while Topalian SL stood out as one of the most cited. Research current situation is notably pivoting toward challenges like immunotherapy resistance and the intricate signaling pathways driving drug resistance. This bibliometric study seeks to provide a comprehensive overview of past and current research trends, emphasizing the potential role of tumor microenvironment, signaling pathways and immune cells in the context of immune checkpoint inhibitors (ICIs) and tumor immune evasion.

Herpes zoster in older adults: Impact on carbon footprint in the United States.
IF 4.8 4区 医学 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2024-12-31 DOI: 10.1080/21645515.2024.2335722

We provide estimates for (I) annual herpes zoster (HZ) cases, (II) carbon costs related to healthcare utilization, and (III) annual carbon emissions due to HZ among ≥50 years of age (YOA) United States (US) population. We estimated the annual number of HZ cases in the US based on available incidence data and demographic data of individuals ≥50 YOA. Both the healthcare resource utilization (HCRU) associated with HZ cases and the unit carbon dioxide equivalent (i.e. CO2e) costs associated with each type of HCRU in the US were estimated based on literature and studies available online. The carbon footprint associated with HZ annually among US adults ≥50 YOA was estimated by multiplying the unit carbon estimates by the HCRU. In the US population aged ≥50 YOA in 2020 (i.e. approximately 118 million), approximately 1.1 million cases of HZ occur annually assuming no vaccination. Based on 2 sources of HCRU the average kgCO2e per HZ patient ranged from 61.0 to 97.6 kgCO2e, with values by age group ranging from 40.9 kgCO2e in patients aged 50-59 to 195.9 kgCO2e in patients ≥80 YOA. The total annual HZ associated carbon ranged between 67,000 and 107,000 tons of CO2e in the US population aged ≥50 YOA. The impact of HZ on carbon footprint in the US results in considerable greenhouse gas (GHG)emissions. Assuming no vaccination, the burden of HZ is projected to rise over the coming years with the aging populations consequently worsening its impact on GHG emissions. (Figure 1).

Short-time mentoring - enhancing female medical students' intentions toward surgical careers.
IF 4.6 2区 医学 Q1 Social Sciences Pub Date : 2024-12-31 DOI: 10.1080/10872981.2024.2347767

Background: Women pursuing a career in surgery or related disciplines are still in the minority, despite the fact that women compose at least half of the medical student population in most Western countries. Thus, recruiting and retaining female surgeons remains an important challenge to meet the need for surgeons and increase the quality of care. The participations were female medical students between their third and fifth academic year. In this study, we applied the well-established psychological theory of planned behavior (TPB) which suggests that the intention to perform a behavior (e.g. pursuing a career in surgery) is the most critical and immediate predictor of performing the behavior. We investigated whether a two-part short-mentoring seminar significantly increases students' intention to pursue a career in a surgical or related specialty after graduation.

Method: The mentoring and role-model seminar was conducted at 2 days for 90 minutes by six inspiring female role models with a remarkable career in surgical or related disciplines. Participants (N = 57) filled in an online survey before (T0) and after the seminar (T1). A pre-post comparison of central TPB concept attitude towards the behavior, 2) occupational self-efficacy and 3) social norm) was conducted using a paired sampled t-test. A follow-up survey was administered 12 months later (T2).

Results: The mentoring seminar positively impacted female students' attitude towards a career in a surgical specialty. Female students reported a significantly increased positive attitude (p < .001) and significantly higher self-efficacy expectations (p < .001) towards a surgical career after participating in the mentoring seminar. Regarding their career intention after the seminar, female students declared a significantly higher intention to pursue a career in a surgical specialty after graduating (p < .001) and this effect seems to be sustainable after 1 year.

Conclusion: For the first time we could show that short-mentoring and demonstrating role models in a seminar surrounding has a significant impact on female medical student decision´s to pursue a career in a surgery speciality. This concept may be a practical and efficient concept to refine the gender disparity in surgery and related disciplines.

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