Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury

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DOI:10.1016/j.stem.2025.06.009
作者：Shawn Goyal, Cynthia X. Guo, Ojas Singh, Adrienne Ranger, Caitlin F. Harrigan, Justin Meade, Alexander Luchak, Derek K. Tsang, Herbert Y. Gaisano, Nan Gao, Scott A. Yuzwa, Jeffrey L. Wrana, Dana J. Ph
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Elsevier

Abstract：ADP-heptose (ADP-Hep), a metabolite produced by gram-negative bacteria, is detected in the host cytosol by the kinase ALPK1, which engages TIFA-dependent innate immune responses. However, th

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