A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors

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DOI:10.1126/science.ads0239
作者：Caroline Weller,?G. Leslie Burnett,?Lingyan Jiang,?Sujata Chakraborty,?Dongyu Zhang,?Nicole A. Vita,?Julien Dilly,?Eejung Kim,?Benjamin Maldonato,?Kyle Seamon,?Diane F. Eilerts,?Anthony Milin,?Abby Ma
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Mutant RAS proteins are among the most prevalent drivers of human cancer, and the glycine to aspartic acid mutation at codon 12 (G12D) is the most common variant. Mutation-selective covalent

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