Pinnick Oxidation on Scale: Process Development of a BDK Inhibitor

已完结 20 由 LZI 发布于 2026/4/3 12:18:53

DOI:10.1021/acs.oprd.4c00177
作者：Joel T. Arcari,?Catherine Buckley,?Leanne M. Buzon,?Yongbo Dan,?Timothy Houck,?Zuxi Jin,?Chao Li,?Peifang Li,?Kai Liu,?Yiyang Liu*,?Javier Magano,?Luis A. Martinez-Alsina,?Bao Nguyen,?Robert Pearson,?
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Abstract：The development of a safe and scalable Pinnick oxidation of an aldehyde to a carboxylic acid in the late-stage synthesis of a BDK inhibitor candidate, PF-07208254, is reported. Extensive pro

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