Artificial intelligence-guided design of LNPs for in vivo targeted mRNA delivery via analysis of the spatial conformation of ionizable lipids.

已完结 20 由 wanting 发布于 2026/4/1 10:08:15

DOI:10.1038/s41551-026-01640-8
作者：Lin-Jia Su,Nan-Nan Wang,Rui Luo,Zi-Han Ji,Haiyan Gu,Chao Yang,Mo-Xi Xu,Juchen Zhang,Qinghua Chen,Meng-Zhen Yu,Chenglin Li,Kelong Fan,Lin Mei,Yuliang Zhao,Yi Wang,Yurui Gao,Hao Wang,Yao-Xin Lin
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1038/s41551-026-01640-8

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Abstract：Efficient mRNA delivery to specific tissues requires optimized ionizable lipids, yet the role of lipid spatial conformation in organ targeting and endosomal escape remains underexplored. Her

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