Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-Cell Engineering Against Pancreatic Tumors.

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DOI:10.1158/2326-6066.CIR-25-0663
作者：Khuloud Bajbouj,?Zebin Xiao,?Leslie Todd,?Li Huang,?Tyler E Papp,?Faris Halilovic,?Jayalakshmi Ramani,?Yanjie Bao,?Matthew Butcher,?Adrian Bot,?Haig Aghajanian,?Carl H June,?Drew Weissman,?Hamideh Par
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American Association for Cancer Research (AACR)

Abstract：Fibroblast activation protein (FAP), which is highly expressed on cancer-associated fibroblasts (CAFs), is a promising therapeutic target to achieve normalization of the tumor microenvironme

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