A PBPK Model of Ternary Cyclodextrin Complex of ST-246 Was Built to Achieve a Reasonable IV Infusion Regimen for the Treatment of Human Severe Smallpox

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DOI:10.3389/fphar.2022.836356
作者：Zhiwei Zhang,?Shuang Fu,?Fu-zhe Wang,?Chunmiao Yang,?Ling-juan Wang,?Meiyan Yang,?Wenpeng Zhang,?Wu Zhong,?Xiaomei Zhuang
文献类型：期刊论文
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Frontiers Media

Abstract：ST-246 is an oral drug against pathogenic orthopoxvirus infections. An intravenous formulation is required for some critical patients. A ternary complex of ST-246/meglumine/hydroxypropyl-β-c

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