Development of a Scalable Synthetic Route to (1R,5R)-2,2-Dimethoxybicyclo[3.1.0]hexan-3-one: An Important Intermediate in the Synthesis of Lenacapavir

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DOI:10.1021/acs.oprd.4c00527
作者：Aline Nunes De Souza, Nagaraju Sakkani, Daryl Guthrie, Rajkumar Lalji Sahani, John M. Saathoff, Samuel R. Hochstetler, Justina M. Burns, Saeed Ahmad, G. Michael Laidlaw, B. Frank Gupton, Douglas A. Kl
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American Chemical Society (ACS)

Abstract：(1R,5R)-2,2-Dimethoxybicyclo[3.1.0]hexan-3-one is used in the asymmetric synthesis of lenacapavir. Herein, we report an enantioselective synthesis of this important chiral intermediate from

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