Risk Evaluation of N-Nitrosamines in Drug-Linker Intermediates Used To Generate Antibody–Drug Conjugates

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DOI:10.1021/acs.oprd.4c00255
作者：Osama Chahrour, Paul G. Bulger, Olivier Dirat, Kate Schrier, Andrew T. Parsons, J. Gair Ford, Frank Bernardoni, Evan M. Hetrick, Llorente R. Bonaga, Kevin P. Cole, Joy Miller, Qunying Zhang, Michael T
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：This position study provides a science-based, holistic approach to evaluating the risks of nitrosamine presence in drug-linkers as intermediates toward antibody–drug conjugate (ADC) drug sub

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