Scalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet

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DOI:10.1021/acs.oprd.4c00117
作者：Benoit Cardinal-David, Shashank Shekhar, Eric M. Phillips, Elizabeth C. Swift, Brian Kotecki, Andrew R. Ickes, Gregory E. Storer, Daniel D. Caspi, Anuj Verma, Eric G. Moschetta, Daniel Tao, Westin H.
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Abstract：Evolution of a synthetic process to prepare ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor, on multikilogram scale is described. The first-generation route utilized chiral resolution o

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