Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

已完结 20 由 Ben 发布于 2026/5/18 7:06:11

DOI:10.1021/jacs.3c07145
作者：Atsushi Ohta*,?Mikimasa Tanada,?Shojiro Shinohara,?Yuya Morita,?Kazuhiko Nakano,?Yusuke Yamagishi,?Ryusuke Takano,?Shiori Kariyuki,?Takeo Iida,?Atsushi Matsuo,?Kazuhisa Ozeki,?Takashi Emura,?Yuuji Sak
文献类型：期刊论文
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Abstract：Establishing a technological platform for creating clinical compounds inhibiting intracellular protein–protein interactions (PPIs) can open the door to many valuable drugs. Although small mo

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