A metabolic alarmin from keratinocytes potentiates systemic humoral immunity

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DOI:10.1038/s41586-026-10167-6
作者：Zhenglin Ji,?Ji Gao,?Shaocun Zhang,?Jiajie Li,?Haijing Wu,?Jing Yao,?Xianqiang Ma,?Yue Xin,?Yongjie Zhu,?Meng Zhao,?Zhidan Zhao,?Kai Shen,?Tao Wu,?Xinmin Qian,?Juanjuan Wang,?Haoran An,?Yuxin Li,?Wenb
文献类型：期刊论文
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Nature

Abstract：How a local infection triggers systemic humoral immunity remains unclear. Here we identify farnesyl pyrophosphate (FPP), a mevalonate pathway metabolic intermediate1, as an endogenous alarmi

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