Impact of Low Skeletal Muscle Mass on the Prognosis of Patients with Head and Neck Cancer Treated Nonsurgically.

IF 2 4区医学 Q2 OTORHINOLARYNGOLOGY Orl-Journal for Oto-Rhino-Laryngology Head and Neck Surgery Pub Date : 2023-01-01 DOI:10.1159/000527307

Yoh-Ichiro Iwasa, Ryosuke Kitoh, Ken Hiramatsu, Kenjiro Sugiyama, Kizuki Watanabe, Rika Yasukawa, Jun Shinagawa, Hiroki Miyajima, Yoh Yokota, Masafumi Kobayashi, Tomohiro Kitano, Kentaro Mori, Yutaka Takumi

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Abstract

Introduction: Sarcopenia, characterized by low skeletal muscle mass, and the outcome of cancer therapy are closely related based on recent research. This study aimed to evaluate the correlation between skeletal muscle mass and prognosis in head and neck cancer (HNC) patients.

Methods: In this study, 51 male patients with HNC treated nonsurgically between January 2016 and April 2018 at Shinshu University Hospital were evaluated. Skeletal muscle mass was assessed using bioelectrical impedance analysis, and the skeletal mass index (SMI) was calculated to classify the patients.

Results: The low-SMI group had a significantly worse overall survival (OS) than the normal-SMI group (3-year OS: 72.0% vs. 93.0%, p = 0.014), and there was a trend toward worse progression-free survival (PFS) in the low-SMI group (3-year PFS: 49.6% vs. 79.3%, p = 0.064). Multivariate analysis also showed that low SMI (p = 0.04) and severe N stage (p = 0.009) were significantly associated with poorer OS.

Conclusion: The pretreatment assessment of SMI using bioelectrical impedance analysis is useful for identifying patients with poor prognoses. To improve the treatment outcome in HNC, we need to think of the intervention, such as cancer rehabilitation and nutritional support, during or before treatment, especially for patients with low SMI.

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低骨骼肌质量对非手术治疗头颈癌患者预后的影响。

最近的研究表明，以骨骼肌质量低为特征的骨骼肌减少症与癌症治疗的结果密切相关。本研究旨在评估头颈癌(HNC)患者骨骼肌质量与预后的相关性。方法:对2016年1月至2018年4月在信州大学医院非手术治疗的51例男性HNC患者进行评价。采用生物电阻抗分析评估骨骼肌质量，并计算骨骼肌质量指数(SMI)对患者进行分类。结果:低smi组的总生存率(OS)明显低于正常smi组(3年OS: 72.0% vs. 93.0%， p = 0.014)，低smi组的无进展生存率(PFS)有更差的趋势(3年PFS: 49.6% vs. 79.3%， p = 0.064)。多因素分析还显示，低SMI (p = 0.04)和严重N分期(p = 0.009)与较差的OS显著相关。结论:应用生物电阻抗分析法对重度精神分裂症患者进行预处理评估，有助于鉴别预后不良的患者。为了改善HNC的治疗效果，我们需要考虑在治疗期间或治疗前进行干预，如癌症康复和营养支持，特别是对低SMI患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orl-Journal for Oto-Rhino-Laryngology Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

2.80

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： ''ORL'' contains concise, original scientific papers of interest for both clinicians and researchers in oto-rhino-laryngology and head and neck surgery. Contributions drawn from the basic sciences cover new knowledge on the anatomy, pathology, pathophysiology, immunology and tumor biology of head and neck and the auditory and vestibular system, the salivary glands, paranasal sinuses and of the organs of the upper respiratory and digestive tract. The practical value of the journal is accentuated by reports of clinical progress in diagnosis and therapy.