Protection against intestinal damage in female Drosophila melanogaster: Comparative contribution of arabinoxylan and its non-covalent/covalent complexes with catechin

IF 3.3 Bioactive Carbohydrates and Dietary Fibre Pub Date : 2025-12-01 Epub Date: 2025-11-03 DOI:10.1016/j.bcdf.2025.100510

Dima Atehli , Tianyu Qi , Rui Liu , Wan Wang , Qiaomei Zhu , Yuanlin Sun , Qingbin Guo , Ji Kang

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Abstract

Both arabinoxylan (AX) and catechin (CA) have shown promising therapeutic potential for inflammatory bowel disease (IBD). However, the efficacy of their covalent (S, CP) and non-covalent (PM) complexes against IBD remains largely unexplored. This study evaluated the therapeutic effects of AX, CA, and their respective complexes in a Drosophila melanogaster model of dextran sodium sulfate (DSS)-induced colitis. Results demonstrated that covalent AX-CA complexes generated by ultrasonic treatment provided the greatest therapeutic benefits, followed by those produced using cold plasma treatment. These complexes significantly improved survival rates, restored locomotor activity, enhanced metabolic rate, improved intestinal barrier function, markedly reduced the expression of genes associated with JAK/STAT signaling pathway, and concurrently upregulated the expression of genes within the Nrf2/Keap1 pathway.

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雌性黑腹果蝇对肠道损伤的保护作用：阿拉伯木聚糖及其与儿茶素的非共价/共价复合物的比较作用

阿拉伯木聚糖（AX）和儿茶素（CA）都显示出治疗炎症性肠病（IBD）的良好潜力。然而，它们的共价（S， CP）和非共价（PM）复合物对IBD的疗效在很大程度上仍未被探索。本研究评估了AX、CA及其各自复合物在葡聚糖硫酸钠（DSS）诱导的黑腹果蝇结肠炎模型中的治疗作用。结果表明，超声处理产生的共价AX-CA复合物具有最大的治疗效果，其次是冷等离子体处理产生的共价AX-CA复合物。这些复合物显著提高了存活率，恢复了运动活性，提高了代谢率，改善了肠道屏障功能，显著降低了JAK/STAT信号通路相关基因的表达，同时上调了Nrf2/Keap1通路相关基因的表达。

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