Idorenyin U. Umoren , Nnanake-Abasi O. Offiong , Niibari W. Vite
{"title":"Antioxidant and neuroprotective effects of Launaea taraxacifolia extract against aluminum-induced neurotoxicity","authors":"Idorenyin U. Umoren , Nnanake-Abasi O. Offiong , Niibari W. Vite","doi":"10.1016/j.abst.2025.12.010","DOIUrl":null,"url":null,"abstract":"<div><div>This study evaluated the antioxidant and neuroprotective effects of ethanol leaf extract and fractions of <em>Launaea taraxacifolia</em> against aluminum chloride-induced neurotoxicity in rats. Sixty-six female Wistar rats were divided into eleven groups, receiving either control treatment, aluminum chloride, donepezil, or different doses/fractions of the plant extract for 21 days. Aluminum chloride significantly reduced antioxidant enzyme activities (SOD, CAT, GPx) and increased lipid peroxidation (MDA). Co-treatment with the ethanol extract, dichloromethane, ethylacetate, and n-butanol fractions restored antioxidant defenses and reduced MDA levels, whereas the n-hexane and aqueous fractions showed little effect. These findings indicate that <em>Launaea taraxacifolia</em> contains bioactive compounds with protective effects against oxidative stress and neuronal injury, supporting its potential as a natural neuroprotective agent.</div></div>","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"8 ","pages":"Pages 141-150"},"PeriodicalIF":0.0000,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in biomarker sciences and technology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S254310642500050X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/12/29 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This study evaluated the antioxidant and neuroprotective effects of ethanol leaf extract and fractions of Launaea taraxacifolia against aluminum chloride-induced neurotoxicity in rats. Sixty-six female Wistar rats were divided into eleven groups, receiving either control treatment, aluminum chloride, donepezil, or different doses/fractions of the plant extract for 21 days. Aluminum chloride significantly reduced antioxidant enzyme activities (SOD, CAT, GPx) and increased lipid peroxidation (MDA). Co-treatment with the ethanol extract, dichloromethane, ethylacetate, and n-butanol fractions restored antioxidant defenses and reduced MDA levels, whereas the n-hexane and aqueous fractions showed little effect. These findings indicate that Launaea taraxacifolia contains bioactive compounds with protective effects against oxidative stress and neuronal injury, supporting its potential as a natural neuroprotective agent.
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