Effect Aluminum Sulfate on Cardiac Tissues and Possible Protective of Vitamin C in Male Rats

Abstract

One of the most extensively distributed elements in the Earth’s crust is aluminum sulfate Al₂(SO₄)₃, used in vaccinations, medications, and food additives. Vitamin C, a necessary nutrient, cannot be generated by humans due to the absence of a crucial enzyme in the biosynthesis route. Previous studies do not report enough data on the role of aluminum sulfate Al₂(SO₄)₃ and vitamin C as companions, so the current study addressed this affair. The twenty rats were divided into 4 groups, five for each group: group 1―control, group 2―accompanied by Al₂(SO₄)₃ at 0.1 mg/1, group 3―accompanied by Al₂(SO₄)₃ at 0.2mg/L and group 4―Al₂(SO₄)₃ at 0.2 mg/L plus vitamin C. For 21 days, the appropriate doses were given orally to rats. Histological analysis of the heart tissue revealed that a lack of effect of aluminum sulfate on inflammatory cells especially macrophages, meaning that vitamin C had an antagonistic effect on aluminum sulfate in when treated doses of Al (0.2 mg/L) with vitamin C.