{"title":"Emerging roles of astrocyte for treatment of focal epilepsy and mechanisms underlying lesion development.","authors":"Quanbao Ji, Yapeng Zhang, Zhuoqin Yang","doi":"10.1007/s11571-026-10433-3","DOIUrl":null,"url":null,"abstract":"<p><p>This study aims to elucidate astrocyte-mediated regulation of focal epileptic seizures and mechanisms underlying the development of epilepsy. To address this, we propose an improved cortical layer model to investigate the function and therapeutic value of astrocyte in neurological disorders. By analyzing the spatio-temporal characteristics of focal epilepsy seizures and their propagation, we find that high frequency inhibitory stimulation appeared to effectively delay or prevent seizures. In addition, the results suggest that different frequencies of Ca<sup>2+</sup> oscillation and levels of coupling strengths have substantial effects on focal epilepsy. Based on experimental and clinical research findings, we develop a potential clinical application process for epilepsy development and delineate its implications for the possibility of postoperative epilepsy recurrence.</p>","PeriodicalId":10500,"journal":{"name":"Cognitive Neurodynamics","volume":"20 1","pages":"68"},"PeriodicalIF":3.9000,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13003040/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cognitive Neurodynamics","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s11571-026-10433-3","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/19 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
This study aims to elucidate astrocyte-mediated regulation of focal epileptic seizures and mechanisms underlying the development of epilepsy. To address this, we propose an improved cortical layer model to investigate the function and therapeutic value of astrocyte in neurological disorders. By analyzing the spatio-temporal characteristics of focal epilepsy seizures and their propagation, we find that high frequency inhibitory stimulation appeared to effectively delay or prevent seizures. In addition, the results suggest that different frequencies of Ca2+ oscillation and levels of coupling strengths have substantial effects on focal epilepsy. Based on experimental and clinical research findings, we develop a potential clinical application process for epilepsy development and delineate its implications for the possibility of postoperative epilepsy recurrence.
期刊介绍：
Cognitive Neurodynamics provides a unique forum of communication and cooperation for scientists and engineers working in the field of cognitive neurodynamics, intelligent science and applications, bridging the gap between theory and application, without any preference for pure theoretical, experimental or computational models.
The emphasis is to publish original models of cognitive neurodynamics, novel computational theories and experimental results. In particular, intelligent science inspired by cognitive neuroscience and neurodynamics is also very welcome.
The scope of Cognitive Neurodynamics covers cognitive neuroscience, neural computation based on dynamics, computer science, intelligent science as well as their interdisciplinary applications in the natural and engineering sciences. Papers that are appropriate for non-specialist readers are encouraged.
1. There is no page limit for manuscripts submitted to Cognitive Neurodynamics. Research papers should clearly represent an important advance of especially broad interest to researchers and technologists in neuroscience, biophysics, BCI, neural computer and intelligent robotics.
2. Cognitive Neurodynamics also welcomes brief communications: short papers reporting results that are of genuinely broad interest but that for one reason and another do not make a sufficiently complete story to justify a full article publication. Brief Communications should consist of approximately four manuscript pages.
3. Cognitive Neurodynamics publishes review articles in which a specific field is reviewed through an exhaustive literature survey. There are no restrictions on the number of pages. Review articles are usually invited, but submitted reviews will also be considered.
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