Anthony W Martinelli, Ruaraidhrí Jordan, Sophia Wugk, James A Nathan, Suzanne M Cloonan
{"title":"Iron in Respiratory Immunity and Infection.","authors":"Anthony W Martinelli, Ruaraidhrí Jordan, Sophia Wugk, James A Nathan, Suzanne M Cloonan","doi":"10.1093/qjmed/hcag090","DOIUrl":null,"url":null,"abstract":"<p><p>Iron is essential for the survival of both humans and pathogens, creating intense competition for the metal during infection. Whilst hosts seek to restrict access to iron via nutritional immunity, microbes including bacteria, viruses, and fungi have adapted unique mechanisms to acquire it. The lungs function as a key battleground in this contest, with local iron homeostasis mediated by tissue-resident alveolar macrophages. Systemic iron status-either overload or deficiency-also dictates the efficacy of innate and adaptive immunity, thus directly influencing the outcomes of respiratory disease. This review will examine our current understanding of the host-iron-pathogen axis in the lung, as well as consider how it could be exploited to improve health outcomes in respiratory infection.</p>","PeriodicalId":20806,"journal":{"name":"QJM: An International Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":6.4000,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"QJM: An International Journal of Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/qjmed/hcag090","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Iron is essential for the survival of both humans and pathogens, creating intense competition for the metal during infection. Whilst hosts seek to restrict access to iron via nutritional immunity, microbes including bacteria, viruses, and fungi have adapted unique mechanisms to acquire it. The lungs function as a key battleground in this contest, with local iron homeostasis mediated by tissue-resident alveolar macrophages. Systemic iron status-either overload or deficiency-also dictates the efficacy of innate and adaptive immunity, thus directly influencing the outcomes of respiratory disease. This review will examine our current understanding of the host-iron-pathogen axis in the lung, as well as consider how it could be exploited to improve health outcomes in respiratory infection.
期刊介绍：
QJM, a renowned and reputable general medical journal, has been a prominent source of knowledge in the field of internal medicine. With a steadfast commitment to advancing medical science and practice, it features a selection of rigorously reviewed articles.
Released on a monthly basis, QJM encompasses a wide range of article types. These include original papers that contribute innovative research, editorials that offer expert opinions, and reviews that provide comprehensive analyses of specific topics. The journal also presents commentary papers aimed at initiating discussions on controversial subjects and allocates a dedicated section for reader correspondence.
In summary, QJM's reputable standing stems from its enduring presence in the medical community, consistent publication schedule, and diverse range of content designed to inform and engage readers.
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