Precision Design of Single-Atom Catalysts for High-Performance Biosensors

IF 8.9 2区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Chemical record Pub Date : 2026-08-17 Epub Date: 2026-04-20 DOI:10.1002/tcr.70153

Xianhong Wang, Xinlu Ye, Zhenhui Li, Neda Anastassova, Haiyue Yang, Dang Zhang, Viktor Korzhikov-Vlakh, Zhengxiang Zhong, Guangming Nie, Ke Zhang, Kwangsoo Shin, Xingwen Zhang, Min Yang, Wei Guo, Lei Wang

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Abstract

Biosensors are crucial in fields like diagnostics but face challenges in sensitivity, selectivity, and stability. Single-atom catalysts (SACs), with atomically dispersed metalsites and precise active centers, provide high catalytic activity that can address these issues. However, their poor biocompatibility hinders integration. Through tailored design, SACs can achieve both high catalysis and biocompatibility. A systematic review connecting their atomic structure to biosensing performance is still needed. This review fills that gap by analyzing recent SAC-based biosensors. It explains how SAC structure governs sensing in electrochemical, colorimetric, electrochemiluminescence, and photoelectrochemical platforms, highlighting improved real-sample performance. Challenges in synthesis and application are discussed, along with future directions for advancing biosensing via single-atom catalysis.

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高性能生物传感器单原子催化剂的精密设计。

生物传感器在诊断等领域至关重要，但在灵敏度、选择性和稳定性方面面临挑战。单原子催化剂（SACs）具有原子分散的金属位点和精确的活性中心，提供了高催化活性，可以解决这些问题。然而，它们较差的生物相容性阻碍了整合。通过量身定制的设计，SACs可以实现高催化和生物相容性。将它们的原子结构与生物传感性能联系起来的系统综述仍然需要。这篇综述通过分析最近基于sac的生物传感器填补了这一空白。它解释了SAC结构如何控制电化学、比色、电化学发光和光电化学平台中的传感，突出了实际样品性能的改进。讨论了合成和应用中的挑战，以及单原子催化生物传感的未来发展方向。

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来源期刊

Chemical record 化学-化学综合

CiteScore

11.00

自引率

3.00%

发文量

188

审稿时长

>12 weeks

期刊介绍： The Chemical Record (TCR) is a "highlights" journal publishing timely and critical overviews of new developments at the cutting edge of chemistry of interest to a wide audience of chemists (2013 journal impact factor: 5.577). The scope of published reviews includes all areas related to physical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, polymer chemistry, materials chemistry, bioorganic chemistry, biochemistry, biotechnology and medicinal chemistry as well as interdisciplinary fields. TCR provides carefully selected highlight papers by leading researchers that introduce the author''s own experimental and theoretical results in a framework designed to establish perspectives with earlier and contemporary work and provide a critical review of the present state of the subject. The articles are intended to present concise evaluations of current trends in chemistry research to help chemists gain useful insights into fields outside their specialization and provide experts with summaries of recent key developments.