Russell G. Wells, Lee E. Neilson, Andrew W. McHill, Nora E. Gray, Joseph F. Quinn, Amie L. Hiller
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引用次数: 0
Abstract
Time-restricted eating (TRE) has shown neuroprotective potential in preclinical models of Huntington’s disease (HD) but has not been tested clinically. Here, we report the results of a 12-week open-label pilot trial ( NCT06490367 ) of 8-h TRE, alongside standard-of-care diet and activity recommendations, in 20 individuals with early-stage HD. We show that TRE is feasible, well tolerated and associated with favourable changes in clinical measures of HD and plasma neurofilament light levels. Overall, these results support the need for further investigation of TRE as a potential lifestyle intervention in HD. A 12-week pilot study suggests that time-restricted eating is well tolerated and associated with favourable clinical outcomes in individuals with early-stage Huntington’s disease.
期刊介绍：
Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.
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