Eventos adversos graves asociados a anestesia general con agentes halogenados en pacientes de ascendencia venezolana. Recomendaciones en práctica clínica

IF 1.3 Q3 ANESTHESIOLOGY Revista Espanola de Anestesiologia y Reanimacion Pub Date : 2026-10-01 Epub Date: 2026-05-26 DOI:10.1016/j.redar.2026.502167

E. Méndez Martínez, C. García Cebrián, A.M. González González, P. Sanabria Carretero, F. Munar Bauzá, G. Alcaraz García-Tejedor, P. González Pizarro, D. Méndez Marín, F. Cassinello, J. Encarnación Martínez, K. Sifontes Romero, M. Almena Marjalizo, C.L. Errando Oyonarte, F.J. Escribà Alepuz, J. García Fernández

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Abstract

The mtND4 Working Group of the Spanish Society of Anesthesiology and Resuscitation (SEDAR) has issued clinical practice recommendations. This article stems from reports of neurological injury and death following general anesthesia in adult and pediatric patients of maternal Venezuelan ancestry, in whom a possible mitochondrial susceptibility associated with the mtND4 m.11232T>C variant of respiratory chain complex I has been identified.

This document is for informational and guidance purposes only. The final clinical decision should be individualized for each patient, taking into account the urgency of the procedure, therapeutic alternatives, and the resources available at each center.

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委内瑞拉血统患者中与卤素制剂全身麻醉相关的严重不良事件。临床实践建议

西班牙麻醉与复苏学会（SEDAR） mtND4工作组发布了临床实践建议。这篇文章源于委内瑞拉血统的成人和儿童患者全身麻醉后神经损伤和死亡的报道，这些患者可能存在与呼吸链复合体I的mtND4 m.11232T>；C变体相关的线粒体易感性。本文档仅供参考和指导。最终的临床决定应针对每位患者，考虑到手术的紧迫性、治疗方案和每个中心可用的资源。

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