Important bioactives carnitine and betaine in milk and dairy products: a systematic review based on text mining and topic analysis.

IF 4.9 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY Food Science of Animal Resources Pub Date : 2026-10-01 DOI:10.1007/s44463-026-00112-6

Lucia Trapanese, Angela Salzano, Nunzio Antonio Cacciola, Gianluca Neglia, Giovanna Bifulco, Marialuisa Balestrieri, Michael J D Occhio, Giuseppe Campanile

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Abstract

A systematic review traced the evolution of research on carnitines and betaines in milk and dairy products. A bibliometric search of the Scopus^® database, using keywords such as "milk/dairy products and biomolecules", "milk/dairy products and carnitine/betaine" retrieved 1.965 publications spanning January 1970 to December 2024. After screening, 179 records were selected for analysis. The most recurrent terms were "metabolit" "cow" and "infant", highlighting the role of milk in the human diet. Topic analysis identified three main themes: Topic 1 grouped studies on metabolic regulation in ruminants and the diet-driven modulation of the milk metabolome; Topic 2 grouped studies on carnitine and betaine as conditionally essential nutrients in early-life nutrition and infant development; Topic 3 grouped studies on dairy bioactives as nutraceuticals in adult chronic disease prevention and therapy. This systematic review recognized the main research themes on the bioactive properties of carnitine and betaine and identified gaps in knowledge and areas for future basic and translational research on the functional role of these bioactives in human and animal health.

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牛奶和乳制品中重要的生物活性物质肉碱和甜菜碱：基于文本挖掘和主题分析的系统综述。

一项系统综述追踪了牛奶和乳制品中肉毒碱和甜菜碱研究的演变。使用关键词“牛奶/乳制品和生物分子”、“牛奶/乳制品和肉碱/甜菜碱”等对Scopus®数据库进行文献测量检索，检索到1970年1月至2024年12月期间的1.965篇论文。筛选后，选取179份记录进行分析。最常出现的词汇是“代谢物”、“奶牛”和“婴儿”，突出了牛奶在人类饮食中的作用。主题分析确定了三个主要主题：主题1：反刍动物代谢调节和饮食驱动的乳代谢组调节的分组研究；主题2：肉碱和甜菜碱在生命早期营养和婴儿发育中的条件必需营养素分组研究；主题3：乳制品生物活性成分在成人慢性疾病预防和治疗中的营养作用。本系统综述确认了肉碱和甜菜碱生物活性特性的主要研究主题，并确定了这些生物活性物质在人类和动物健康中的功能作用的未来基础和转化研究的知识和领域的空白。

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来源期刊

Food Science of Animal Resources Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

6.70

自引率

6.70%

发文量

期刊介绍： Food Science of Animal Resources (Food Sci. Anim. Resour.) is an international, peer-reviewed journal publishing original research and review articles on scientific and technological aspects of chemistry, biotechnology, processing, engineering, and microbiology of meat, egg, dairy, and edible insect/worm products.