Vibhudutta Awasthi, Tarun W. Dasari, Kenichi A. Tanaka
{"title":"Cardioprotection Is a Delivery Problem: A First-Medical-Contact Framework for Acute Myocardial Infarction","authors":"Vibhudutta Awasthi, Tarun W. Dasari, Kenichi A. Tanaka","doi":"10.1021/acsptsci.6c00552","DOIUrl":null,"url":null,"abstract":"<p>Dozens of agents that limit reperfusion injury preclinically\r\nhave\r\nfailed clinically. These failures are architectural, not biological:\r\nthe right biology reaches the wrong place, as the wrong molecule,\r\nat the wrong time, judged by the wrong end point. We recast each as\r\na design constraint and specify a staged regimen anchored at first\r\nmedical contact.</p>","PeriodicalId":36426,"journal":{"name":"ACS Pharmacology and Translational Science","volume":"9 10","pages":"3000–3004"},"PeriodicalIF":3.7000,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Pharmacology and Translational Science","FirstCategoryId":"1085","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsptsci.6c00552","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/9/17 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Dozens of agents that limit reperfusion injury preclinically
have
failed clinically. These failures are architectural, not biological:
the right biology reaches the wrong place, as the wrong molecule,
at the wrong time, judged by the wrong end point. We recast each as
a design constraint and specify a staged regimen anchored at first
medical contact.
期刊介绍：
ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action, and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest to the journal. Nonetheless, all innovative and impactful research that has an articulated translational relevance will be considered.
ACS Pharmacology & Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition.
Authors are encouraged to use the pre-submission inquiry mechanism to ensure relevance and appropriateness of research.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
