{"title":"The state of tryptophan-containing sites of human, bovine and rabbit plasminogens with changing solution pHs","authors":"V.N. Nikandrov, G.V. Vorobyova, N.V. Demidchik","doi":"10.1016/0020-711X(94)90076-0","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. The state of tryptophan-containing sites is proved to be stable by intrinsic tryptophan fluorescence with pH 5–8, 7–9, and 6–9 in human, rabbit and bovine plasminogen molecules, respectively.</p></span></li><li><span>2.</span><span><p>2. With pH < 5.0 tryptophan-containing sites of human zymogen (in contrast to rabbit and bovine ones) undergo conformational transitions.</p></span></li><li><span>3.</span><span><p>3. With the shift of solution pH from 9 to 12 tryptophan-containing sites of human and rabbit plasminogens are partially disorganized, while tryptophanyls become more available for solvent.</p></span></li><li><span>4.</span><span><p>4. Tryptophan-containing sites of bovine plasminogen molecules are less mobile in structure during changes of solution pH.</p></span></li></ul></div>","PeriodicalId":13733,"journal":{"name":"International Journal of Biochemistry","volume":"26 8","pages":"Pages 1043-1047"},"PeriodicalIF":0.0000,"publicationDate":"1994-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0020-711X(94)90076-0","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Biochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0020711X94900760","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2003/2/5 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
1.
1. The state of tryptophan-containing sites is proved to be stable by intrinsic tryptophan fluorescence with pH 5–8, 7–9, and 6–9 in human, rabbit and bovine plasminogen molecules, respectively.
2.
2. With pH < 5.0 tryptophan-containing sites of human zymogen (in contrast to rabbit and bovine ones) undergo conformational transitions.
3.
3. With the shift of solution pH from 9 to 12 tryptophan-containing sites of human and rabbit plasminogens are partially disorganized, while tryptophanyls become more available for solvent.
4.
4. Tryptophan-containing sites of bovine plasminogen molecules are less mobile in structure during changes of solution pH.
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